Valentina Franceschi

Unweighted Hardy inequalities on the Heisenberg group and in step-two Carnot groups

Lorenzo D'Arca, Luca Fanelli, Valentina Franceschi, Dario Prandi

We establish unweighted Hardy-type inequalities on step-two Carnot groups with one-dimensional vertical layer, with explicit lower bounds for the optimal Hardy constant. The approach is based on a quantitative integration-by-parts mechanism that replaces the non-horizontal Euler vector field by a suitably constructed …

Distal and local mucosal immunization with a BoHV-4-based vector delivering CpHV-1 gD confers protection against intravaginal CpHV-1 challenge in goats

Amienwanlen Eugene Odigie, Sergio Minesso, Valentina Franceschi, Grazia Greco et autres

Effective vaccines against sexually transmitted pathogens must elicit protective immunity at mucosal surfaces, particularly within the female reproductive tract. Caprine herpesvirus 1 (CpHV-1) causes genital disease, reproductive failure, and neonatal mortality in goats and provides a biologically relevant large-animal model for human …

it (code pays fourni par la source)

PYGO2 is overexpressed in multiple myeloma patients with 1q21 amplification, driving plasma cell proliferation and cell cycle progression

Nicolas Thomas Iannozzi, Paola Storti, Rosanna Vescovini, Camilla Sitzia et autres

Abstract Chromosome 1q21 copy number alterations (1q21+) are among the most frequent secondary events in multiple myeloma (MM), correlating with poor prognosis and therapy resistance. However, the molecular drivers of this lesion remain poorly defined. Here, we identify PYGO2, a Wnt/β-catenin co-activator …

it, us (code pays fourni par la source)

Cross-species oncolytic virotherapy in vitro: BoHV4EGFPΔTK as a novel candidate against canine osteosarcoma and histiocytic sarcoma

Melania Di Pentima, Sergio Minesso, Valentina Franceschi, Rosanna Di Lecce et autres

it, de (code pays fourni par la source)

Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales‐Altozano, José Manuel Rojas, Sergio Minesso et autres

Abstract Bluetongue virus (BTV) remains a major threat to livestock health and agricultural economies worldwide due to its multiple serotypes, vector transmission, and wide geographic distribution. Vaccination is essential for controlling BTV outbreaks; however, developing vaccines that provide broad protection while complying …

it, es (code pays fourni par la source)

Additional file 1 of Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales-Altozano, José M. Rojas, Sergio Minesso et autres

Additional file 1. Gating strategy and representative examples of intracellular cytokine staining assays analyzed by flow cytometry. Splenocytes from vaccinated mice (BoHV-4, BoHV-4 VP7, BoHV-4 VP2, and BoHV-4 VP2+VP7) were left unstimulated as control or were stimulated with inactivated BTV-8 (i-BTV). Gating …

it, lk (code pays fourni par la source)

Additional file 2 of Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales‐Altozano, José Manuel Rojas, Sergio Minesso et autres

Additional file 2. Staining of pINT2-(TK-CMV-VP7-HA-TK)-transfected HEK293 cells and stained with an anti-HA mAb antibody and analyzed by immunofluorescence and flow cytometry.

it, lk (code pays fourni par la source)

Additional file 1 of Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales-Altozano, José M. Rojas, Sergio Minesso et autres

Additional file 1. Gating strategy and representative examples of intracellular cytokine staining assays analyzed by flow cytometry. Splenocytes from vaccinated mice (BoHV-4, BoHV-4 VP7, BoHV-4 VP2, and BoHV-4 VP2+VP7) were left unstimulated as control or were stimulated with inactivated BTV-8 (i-BTV). Gating …

it, lk (code pays fourni par la source)

Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales-Altozano, José M. Rojas, Sergio Minesso et autres

Abstract Bluetongue virus (BTV) remains a major threat to livestock health and agricultural economies worldwide due to its multiple serotypes, vector transmission, and wide geographic distribution. Vaccination is essential for controlling BTV outbreaks; however, developing vaccines that provide broad protection while complying …

it, lk (code pays fourni par la source)

Additional file 2 of Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales‐Altozano, José Manuel Rojas, Sergio Minesso et autres

Additional file 2. Staining of pINT2-(TK-CMV-VP7-HA-TK)-transfected HEK293 cells and stained with an anti-HA mAb antibody and analyzed by immunofluorescence and flow cytometry.

it, lk (code pays fourni par la source)

Expression of bluetongue virus core proteins VP2 and VP7 by bovine herpesvirus-4 confers protection against virulent challenge in a mouse model

Valentina Franceschi, Pablo Nogales-Altozano, José M. Rojas, Sergio Minesso et autres

Abstract Bluetongue virus (BTV) remains a major threat to livestock health and agricultural economies worldwide due to its multiple serotypes, vector transmission, and wide geographic distribution. Vaccination is essential for controlling BTV outbreaks; however, developing vaccines that provide broad protection while complying …

it, lk (code pays fourni par la source)

Inducing Antigen‐Specific and Functional Immune Responses in Mice Toward Bovine Herpesvirus 1 and Bovine Respiratory Syncytial Virus by Chimeric Peptides Delivered by Bovine Herpesvirus 4‐Based Vector

Antonino Di Lorenzo, Sergio Minesso, Chiara Cossu, Valentina Franceschi et autres

Bovine respiratory disease (BRD) remains a major health and economic challenge for the cattle industry, driven by the interplay of viral and bacterial pathogens that compromise animal welfare, productivity and antimicrobial stewardship. Among the primary viral agents, Bovine herpesvirus 1 (BoHV-1) and …

it (code pays fourni par la source)