2026
conference-paper
OpenAlex
A P Roggio, Benjamin Kirchweger, A Wasilewicz, J M Rollinger et autres
Ferula assa-foetida L. (Apiaceae) is a plant native to southern Iran and Afghanistan. Its dried resin, called asafoetida, has been used for millennia as a spice and in traditional medicine for various indications [ 1 ]. In particular, its anti-inflammatory effects have …
de, at
(code pays fourni par la source)
2026
article
OpenAlex
Tobias Burghardt, Sophie Thalmayr, Lennart Obeser, Jana Pöhmerer et autres
Double pH-responsive lipo-xenopeptides combine polar oligoamino acids (OAAs) such as succinoyl tetraethylene pentamine (Stp) with apolar lipoamino fatty acid (LAF) domains. The resulting potent mRNA carriers undergo a profound shift in their polarity upon endosomal protonation. In the current chemical evolution approach, …
de, cz, jp
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
A. Jauch, Judith Sailer, Jessica L. Braun, Elena Czeslik et autres
Natural compounds are a valuable source of highly active biomolecules for the discovery of innovative drug targets as well as drug leads. The natural compound neocarzilin A (NCA) exhibits pronounced antiproliferative and antimigratory activity, which we previously ascribed to the target proteins …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Matthias Völkl, Luisa D. Burgers, Thomas Zech, Sarah Ciurus et autres
Homoharringtonine (HHT), an alkaloid from the plant genus Cephalotaxus , disrupts the first elongation phase of protein synthesis by interacting with the 60S ribosomal subunit, making it effective in treating diseases such as myeloid leukaemia. Semi-synthetically produced as omacetaxine mepesuccinate, HHT has …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Maibritt Kretschmer, Angelika M. Vollmar, Stefan Zahler
Angiogenesis, the process of vessel formation from pre-existing ones, is modulated by the local stiffness of the extracelluar matrix. We have previously shown that Notch signaling, a key pathway in angiogenesis, responds to substrate stiffness in endothelial cells. In the current work, …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres
Abstract Fluorchinolone (FQs) sind eine wichtige Klasse potenter Breitbandantibiotika. Ihre allgemeine Verwendung wird jedoch zunehmend durch unerwünschte Nebenwirkungen eingeschränkt. Während allgemeine Mechanismen für die Fluorchinolon‐assoziierte Behinderung (FQAD) identifiziert wurden, sind die zugrundeliegenden molekularen Ziele der Toxizität nach wie vor schwer fassbar. In …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Till Reinhardt, Yassmine El Harraoui, Robin Alexander Rothemann, A. Jauch et autres
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …
de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Corinna Kersten, Stefan Zahler, Sabine Schneider
In the last decade the important role of small non-coding RNAs such as micro RNAs (miRs) in gene regulation in healthy and disease states became more and more evident. The miR-200-family of miRs has been shown to play a critical role in …
de
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Amir Tayaranian Marvian, Tabea Strauß, Qilin Tang, Benjamin J. Tuck et autres
BACKGROUND: The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical step in propagating pathologic Tau in the brain is the transport from the extracellular environment and accumulation inside naïve neurons. Current research indicates …
de, gb, dk
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Mehak Passi, Jan B. Stöckl, Thomas Fröhlich, Simone Moser et autres
MST2 (STK3) is a major upstream kinase in the Hippo signalling pathway, an evolutionary conserved pathway in regulation of organ size, self-renewal and tissue homeostasis. Its downstream effectors are the transcriptional regulators YAP and TAZ. This pathway is regulated by a variety …
de, at
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Lorenz Isert, Mehak Passi, Benedikt Freystetter, Maximilian Grab et autres
model was developed and systematically characterized including physico-chemical, cell-biological and biophysical parameters. Using electrospinning, the architecture of tumor-associated collagen signatures (TACS5 and TACS6) was mimicked. By employing a rotating cylinder or static plate collector set-up, aligned fibers (TACS5-like structures) and randomly orientated …
de, us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Till Reinhardt, Nina C. Bach, Robin Alexander Rothemann, A. Jauch et autres
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain elusive. …
de
(code pays fourni par la source)