Amir Tayaranian Marvian

Insight into the Neuroprotective Mechanisms of Resveratrol: Inhibition of Alpha-Synuclein Fibrillation and its Role in Mitigating Toxicity

Sepideh Sadat Seyedfatemi, Soha Parsafar, Amir Tayaranian Marvian, Hamdam Hourfar et autres

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Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Amir Tayaranian Marvian, Tabea Strauß, Qilin Tang, Benjamin J. Tuck et autres

BACKGROUND: The prion-like spreading of Tau pathology is the leading cause of disease progression in various tauopathies. A critical step in propagating pathologic Tau in the brain is the transport from the extracellular environment and accumulation inside naïve neurons. Current research indicates …

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LRP1 : A Novel Mediator of Tau Uptake

Amir Tayaranian Marvian, María Stamelou, Günter U. Höglinger

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The status of the terminal regions of α-synuclein in different forms of aggregates during fibrillization

Amir Tayaranian Marvian, Farhang Aliakbari, Hossein Mohammad‐Beigi, Zeinab Alsadat Ahmadi et autres

The α-synuclein (αSN) amyloid fibrillization process is known to be a crucial phenomenon associated with neuronal loss in various neurodegenerative diseases, most famously Parkinson's disease. The process involves different aggregated species and ultimately leads to formation of β-sheet rich fibrillar structures. Despite …

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Four-repeat tauopathies

Thomas W. Rösler, Amir Tayaranian Marvian, Matthias Brendel, Niko-Petteri Nykänen et autres

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In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies

Amir Tayaranian Marvian, David J. Koss, Farhang Aliakbari, Dina Morshedi et autres

Alpha-synuclein (α-Syn) is a central player in Parkinson's disease (PD) and in a spectrum of neurodegenerative diseases collectively known as synucleinopathies. The protein was first associated with PD just over 20 years ago, when it was found to (i) be a major …

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The primary neuronal cells are more resistant than PC12 cells to α-synuclein toxic aggregates

Mansooreh Heravi, Leila Dargahi, Soha Parsafar, Amir Tayaranian Marvian et autres

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The potential of zwitterionic nanoliposomes against neurotoxic alpha-synuclein aggregates in Parkinson's Disease

Farhang Aliakbari, Hossein Mohammad‐Beigi, Nasrollah Rezaei‐Ghaleh, Stefan Becker et autres

The protein α-synuclein (αSN) aggregates to form fibrils in neuronal cells of Parkinson's patients. Here we report on the effect of neutral (zwitterionic) nanoliposomes (NLPs), supplemented with cholesterol (NLP-Chol) and decorated with PEG (NLP-Chol-PEG), on αSN aggregation and neurotoxicity. Both NLPs retard …

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Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome

Farhang Aliakbari, Ali Akbar Shabani, Hassan Bardania, Hossein Mohammad‐Beigi et autres

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Neurotoxicity of pre-incubated alpha-synuclein with neutral nanoliposomes on PC12 and SHSY5Y cell lines

Farhang Aliakbari, Ali Akbar Shabani, Hassan Bardania, Hadieh Alsadat Eslampanah Seyedi et autres

Alpha-synuclein (α-Syn) is an abundant protein in the brain with high tendency to convert into toxic aggregated forms that are involved in neurons degeneration in Parkinson's patients (PD). The conversion of α-Syn toward toxic aggregates may associate with bio-membranes and the interaction …

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Exophers expel toxic aggregates: The new discovery of a defense mechanism against misfolded or toxic proteins

Amir Tayaranian Marvian, Dina Morshedi

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Inhibition of lysozyme fibrillation by human serum albumin nanoparticles: Possible mechanism

Negar Mirzazadeh Dizaji, Hossein Mohammad‐Beigi, Farhang Aliakbari, Amir Tayaranian Marvian et autres

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