W. Todd Cade

Adjunctive nebulization of Idursulfase to intravenous treatment enhances cardiac proteome adaptations in IDS-KO mice

Vinicius Marcel Mariani, Anatália Labilloy, W. Todd Cade, Paulo R. Ferreira et autres

ABSTRACT Mucopolysaccharidosis Type II (MPS-II) is a rare X-linked lysosomal storage disorder, characterized by deficiency of the lysosomal hydrolase iduronate 2-sulphatase (IDS). Cardiac impairments contribute to mortality in patients. Enzyme replacement therapy (ERT) with Idursulfase is a promising treatment for the cardiac …

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Feasibility and acceptability of remote ischemic conditioning combined with low-intensity resistance training in older adults with mobility impairments: A randomized controlled pilot trial protocol

Stephanie Milosovic, Andrew Albright, Tiffany Hilton, Natanael Casiano-Agosto et autres

BACKGROUND: Rehabilitation outcomes in older individuals with mobility impairments are often suboptimal due to limited capacity for high-intensity exercise. Remote ischemic conditioning is a low-cost, non-invasive technique that may enhance physiological adaptations to exercise. OBJECTIVE: To assess the feasibility and acceptability of …

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Metabolic Health and Heterogenous Outcomes of Prenatal Interventions

Emily W. Flanagan, Kimberly L. Drews, W. Todd Cade, Paul W. Franks et autres

Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. …

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Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, or Substrate Metabolism in Barth Syndrome

W. Todd Cade, Kathryn L. Bohnert, Linda R. Peterson, Lisa de las Fuentes et autres

ABSTRACT Barth syndrome (BTHS) is a rare X‐linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation can improve heart function in BTHS patients, the metabolic effects …

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0309 Neighborhood Perceptions and Sleep Health in Pregnant African American Women of Low Socioeconomic Status

Sarah S. Farabi, W. Todd Cade, Candice Woolfolk, C. Schwarz et autres

Abstract Introduction Poor sleep health is associated with pregnancy complications. Perceptions of neighborhood likely affect sleep in pregnant women. African American women of low socioeconomic status (SES) often live in neighborhoods with disproportionally high crime and traffic. The aim of this study …

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Noise-Related Injury During Robotic versus Manual Total Knee Arthroplasty

Dianne N. Pagan, Natalia Cruz-Ossa, W. Todd Cade, Michele R. D’Apuzzo et autres

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Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

Senthil Selvaraj, Lydia Coulter Kwee, Elizabeth J. Thompson, M He et autres

Growing evidence supports therapeutic ketosis in heart failure with reduced ejection fraction, though uncertainty exists regarding use with SGLT2i and dose-dependent effects. In a phase I trial of 2 ketone ester (KE) doses in 20 heart failure with reduced ejection fraction participants, …

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Abstract 4116177: Metabolic and Pharmacokinetic Profiling of Ketone Ester by Background SGLT2 Inhibitor Therapy in Heart Failure with Reduced Ejection: A Phase I Clinical Trial

Senthil Selvaraj, Chunyan He, Elizabeth J. Thompson, Christoph P. Hornik et autres

Background: Growing evidence supports a therapeutic role for ketones in HFrEF. However, no pharmacokinetic (PK) studies are available to guide further investigation, and uncertainty exists regarding use with the ketogenic SGLT2i and dose-dependent effects. Methods: We conducted a phase I trial of …

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Rescue of mitochondrial dysfunction through alteration of extracellular matrix composition in barth syndrome cardiac fibroblasts

Janny Piñeiro-Llanes, Silveli Suzuki‐Hatano, Ananya Jain, Sree Venigalla et autres

Fibroblast-ECM (dys)regulation is associated with a plethora of diseases. The ECM acts as a reservoir of inflammatory factors and cytokines that mediate molecular mechanisms within cardiac cell populations. The role of ECM-mitochondria crosstalk in the development and progression of cardiac disorders remains …

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Feasibility of a Community-Based Structured Exercise Program for Persons With Spinal Cord Injury

Kelly L. Taylor, Rachel Heeb Desai, Kimberly A. Walker, Susan Tucker et autres

Date Presented 03/23/24 This poster highlights the results of a randomized controlled trial of a community-based exercise program that improved health outcomes for persons with spinal cord injury (PwSCI) and proposes ideas to address physical activity for PwSCI. Primary Author and Speaker: …

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Feasibility of a community-based structured exercise program for persons with spinal cord injury

Kerri A. Morgan, Kelly L. Taylor, Rachel Heeb Desai, Kimberly A. Walker et autres

Objectives (1) Examine the feasibility of a community-based exercise intervention for persons with spinal cord injury and (2) compare the cardiorespiratory fitness, skeletal muscle strength, and psychosocial well-being of participants in the intervention group versus control group.Design Community-based pilot randomized controlled trial. …

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One episode of low intensity aerobic exercise prior to systemic AAV9 administration augments transgene delivery to the heart and skeletal muscle

Christina A. Pacak, Silveli Suzuki‐Hatano, Fatemeh Khadir, Audrey L. Daugherty et autres

INTRODUCTION: The promising potential of adeno-associated virus (AAV) gene delivery strategies to treat genetic disorders continues to grow with an additional three AAV-based therapies recently approved by the Food and Drug Administration and dozens of others currently under evaluation in clinical trials. …

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