Sree Venigalla

Evaluating the Therapeutic Potential of Geranylgeraniol (GGOH) in an iPSC-Derived Duchenne Muscular Dystrophy Disease Model (P3-8.001)

Johnnie Turner, Mekala Gunasekaran, Sree Venigalla, Hannah Littel et autres

To determine whether geranylgeraniol (GGOH) treatment of isogenic induced pluripotent stem cell (iPSC)-derived Duchenne muscular dystrophy (DMD) and control myoblasts promotes rescue of myotube fusion and downstream cellular processes in the DMD cells.

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Effects of HMG CoA reductase ( HMGCR ) deficiency on skeletal muscle development

Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner et autres

Pathogenic variants in HMGCR were recently linked to a limb-girdle muscular dystrophy (LGMD) phenotype. The protein product HMG CoA reductase (HMGCR) catalyzes a key component of the cholesterol synthesis pathway. The two other muscle diseases associated with HMGCR, statin-associated myopathy (SAM) and …

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Rescue of mitochondrial dysfunction through alteration of extracellular matrix composition in barth syndrome cardiac fibroblasts

Janny Piñeiro-Llanes, Silveli Suzuki‐Hatano, Ananya Jain, Sree Venigalla et autres

Fibroblast-ECM (dys)regulation is associated with a plethora of diseases. The ECM acts as a reservoir of inflammatory factors and cytokines that mediate molecular mechanisms within cardiac cell populations. The role of ECM-mitochondria crosstalk in the development and progression of cardiac disorders remains …

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Effects of HMGCR deficiency on skeletal muscle development

Mekala Gunasekaran, Hannah R. Littel, Natalya M. Wells, Johnnie Turner et autres

Abstract Pathogenic variants in HMGCR were recently linked to a limb-girdle muscular dystrophy (LGMD) phenotype. The protein product HMG CoA reductase (HMGCR) catalyzes a key component of the cholesterol synthesis pathway. The two other muscle diseases associated with HMGCR, statin-associated myopathy (SAM) …

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MED12 Regulates Human Adipose-Derived Stem Cell Adipogenesis and Mediator Kinase Subunit Expression in Murine Adipose Depots

Sree Venigalla, Joseph A. Straub, Onyekachi Idigo, Caroline H. Rinderle et autres

The mediator kinase module plays a critical role in the regulation of transcription during metabolic processes. Here we demonstrate that in human adipose-derived stem cells (hASCs), kinase module subunits have distinct mRNA and protein expression profiles during different stages of adipogenesis. In …

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04. Wastewater Detection of SARA-Cov-2

Laura Lee, Sree Venigalla, H. Norman Barnett, Paul Austin et autres

06. The Influence of MED12 Knockdown on Adipogenesis

Emily Meaney, Jamie Sparkman, Joseph A. Straub, Sree Venigalla

Mediator's Kinase Module: A Modular Regulator of Cell Fate

Joseph A. Straub, Sree Venigalla, Jamie J. Newman

Selective gene expression is crucial in maintaining the self-renewing and multipotent properties of stem cells. Mediator is a large, evolutionarily conserved, multi-subunit protein complex that modulates gene expression by relaying signals from cell type-specific transcription factors to RNA polymerase II. In humans, …

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