Linda R. Peterson

Plasma Ceramides Levels in Severe COVID-19 Disease: Correlations with Survival

Tri Pham, A. Heredia Castillo, Andrew W. Atkinson, Linda R. Peterson et autres

Background: Dysregulated inflammatory processes have been associated with severe COVID-19 disease. Ceramides, bioactive lipids involved in inflammatory signaling, have been utilized to predict outcomes in chronic cardiometabolic diseases and pancreatic cancer, but their role in COVID-19 remains unknown. Methods: This observational study …

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Altered myocardial oxygenation and impaired energy efficiency: a pilot study in patients with light chain cardiac amyloidosis

Liya Dai, K F Wang, Ran Li, Jun Qiao et autres

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Impaired myocardial oxygen metabolism and energy efficiency in patients with dilated cardiomyopathy

Liya Dai, Jinghan Qiao, Keyan Wang, Ran Li et autres

Quantitative assessment of cardiac phosphocreatine metabolism under physiological and pharmacological stress using chemical exchange saturation transfer magnetic resonance imaging

Qi Huang, Caleb Berberet, Ryan Wahidi, Todd Pavek et autres

Phosphocreatine (PCr) exhibits a distinct chemical exchange saturation transfer (CEST) resonance at ~2.5 ppm with slower exchange kinetics and lower pH sensitivity than creatine. This pilot study evaluated the feasibility of quantifying myocardial PCr-dominated concentration ([PCr] d ) using CEST cardiac MRI …

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Quantitative Phosphocreatine Mapping with a Transformer-Based Regression Network

Qi Huang, Haoteng Tang, Han Tang, Caleb Berberet et autres

Phosphocreatine (PCr) is the key element of buffering adenosine triphosphate (ATP) concentration for sustaining the high energy demand of cardiomyocytes, thus maintaining normal mechanical function. CEST MRI has been employed to capture potential changes in myocardial PCr. A quantitative PCr network (QPCrNet) …

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Altered Myocardial Oxygenation and Impaired Energy Efficiency: A Pilot Study in Patients With Light Chain Cardiac Amyloidosis

Liya Dai, Ran Li, Jun Qiao, Caleb Berberet et autres

ABSTRACT Background Cardiac magnetic resonance (MR) enables assessment of myocardial oxygenation without contrast media. However, how myocardial oxygen metabolism is altered in light chain cardiac amyloidosis (AL‐CA) patients remains poorly understood. Purpose To leverage newly developed MR techniques for the evaluation of …

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Plasma Ceramide C24:0/C16:0 Relates to Outcomes in Patients With Heart Failure With Preserved Ejection Fraction

Linda R. Peterson, Stefan David Gross, Marcus Dörr, Xuntian Jiang et autres

BACKGROUND: Ceramides are complex sphingolipids with pleiotropic effects. The ratio of specific ceramides (plasma C24:0/C16:0) is inversely related to incident heart failure (HF) and all-cause death in large, community-based cohorts without pre-existing HF. Whether plasma C24:0/C16:0 relates to outcomes in patients with …

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Quantitative assessment of cardiac oxidative metabolism under physiological and pharmacological stress using CEST imaging and MRS

Qi Huang, Caleb Berberet, Cihat Eldeniz, Ryan Wahidi et autres

Motivation: Assessing changes of the cardiac phosphocreatine (PCr) at rest and stress may be a valuable biomarker to cardiometabolic health. Goal(s): To test the feasibility of quantifying changes of PCr concentrations in vivo. Approach: Evaluating feasibility of the cardiac CEST imaging in …

Perspectives: Recent advances in community-based interventions for cardiovascular disease disparities in the United States

Farbod Zahedi Tajrishi, Daphne P. Ferdinand, William P. Herbst, Linda R. Peterson et autres

Despite decades of progress in prevention and management, cardiovascular disease (CVD) remains the leading cause of mortality in the United States (US) and globally, with persistent and even widening disparities in outcomes across racial, ethnic, geographic, and socioeconomic groups. As a complement …

Cardiac Transplantation Does Not Improve Exercise Tolerance, Muscle Mass, or Substrate Metabolism in Barth Syndrome

W. Todd Cade, Kathryn L. Bohnert, Linda R. Peterson, Lisa de las Fuentes et autres

ABSTRACT Barth syndrome (BTHS) is a rare X‐linked recessive disorder characterized by mutations in the TAFAZZIN gene, leading to mitochondrial dysfunction, cardioskeletal myopathy, neutropenia, exercise intolerance, and growth delay. While cardiac transplantation can improve heart function in BTHS patients, the metabolic effects …

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Model‐based self‐supervised learning for quantitative assessment of myocardial oxygen extraction fraction and myocardial blood volume

Qi Huang, Haoteng Tang, Keyan Wang, Ran Li et autres

PURPOSE: To develop a model-driven, self-supervised deep learning network for end-to-end simultaneous mapping of myocardial oxygen extraction fraction (mOEF) and myocardial blood volume (MBV). METHODS: An asymmetrical spin echo-prepared sequence was used to acquire mOEF and MBV images. By integrating a physical …

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Predictive Value of VO2peak in Adult Congenital Heart Disease in Comparison With Heart Failure With Reduced Ejection Fraction

Andrea Ribeiro Soares, Lauren K. Park, Emily Mansour, Elena Deych et autres

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