Jula Huppert

Vascular basement membrane laminins modulate functional zonation of cerebral microvessels

Tushar Deshpande, Kishan Kapupara, Melanie‐Jane Hannocks, Jula Huppert et autres

We investigated whether basement membrane (BM) laminins influence regional differences in the vasculature by performing single-cell RNA sequencing on cerebral blood vessels from mice lacking the major vascular laminins in endothelial and smooth muscle BMs, laminin α4 ( Lama4 −/− ) and …

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Vascular Basement Membrane Laminins Modulate Functional Zonation of Cerebral Microvessels

Tushar Deshpande, Kishan Kapupara, Melanie‐Jane Hannocks, Jula Huppert et autres

Abstract We investigated whether vascular basement membrane (BM) laminins influence vascular zonation by performing single-cell RNA sequencing on cerebral blood vessels from mice lacking the major vascular laminins in endothelial and smooth muscle BMs, laminin α4 ( Lama4 -/- ) and laminin …

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IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Tommy Regen, Sandrine Isaac, Ana Amorim, Nicolás Gonzalo Núñez et autres

cells did not diminish their encephalitogenic capacity. Reconstitution of a wild-type-like intestinal microbiota or reintroduction of IL-17A specifically into the gut epithelium of IL-17A/F-deficient mice reestablished their susceptibility to EAE. Thus, our data demonstrated that IL-17A and IL-17F are not encephalitogenic mediators …

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IL-17 controls central nervous system autoimmunity through the intestinal microbiome

Tommy; https://orcid.org/0000-0002-7275-3330 Regen, Sandrine; https://orcid.org/0000-0001-8306-3901 Isaac, Ana; https://orcid.org/0000-0002-1708-0452 Amorim, Nicolás Gonzalo; https://orcid.org/0000-0003-3837-270X Núñez et autres

Interleukin-17A- (IL-17A) and IL-17F-producing CD4+ T helper cells (TH17 cells) are implicated in the development of chronic inflammatory diseases, such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). TH17 cells also orchestrate leukocyte invasion of the central nervous system …

Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

Katharina Helene Susek, Éva Korpos, Jula Huppert, Chuan Wu et autres

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Molecular characterization of perivascular drainage pathways in the murine brain

Melanie‐Jane Hannocks, Michelle E. Pizzo, Jula Huppert, Tushar Deshpande et autres

Perivascular compartments surrounding central nervous system (CNS) vessels have been proposed to serve key roles in facilitating cerebrospinal fluid flow into the brain, CNS waste transfer, and immune cell trafficking. Traditionally, these compartments were identified by electron microscopy with limited molecular characterization. …

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Abstract 19862: T-cell Specific Overexpression of IL-17A Induces Vascular Dysfunction Per Se Without Increasing Vascular Inflammation and IL-17 Receptor a Knock-out Attenuates Angiotensin-II Induced Vascular Inflammation

Rebecca Schüler, Susanne Helena Karbach, Katrin Schäfer, Sabine Kossmann et autres

Introduction: Interleukin-17A (IL-17A) plays a major role in the development of vascular dysfunction although there still remain open questions concerning the mechanisms. Hypothesis: We investigate...

The Contribution of the Extracellular Matrix to the BBB in Steady State and Inflammatory Conditions

Melanie‐Jane Hannocks, Jula Huppert, Xueli Zhang, Éva Korpos et autres

Central Nervous System: Microanatomy

Melanie‐Jane Hannocks, Jula Huppert, Lydia M. Sorokin

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The gut microflora determines pathogenicity in Th17-mediated CNS autoimmunity

Tommy Regen, Nir Yogev, Jula Huppert, Sandrine Isaac et autres

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An Alternative Pathway of Imiquimod-Induced Psoriasis-Like Skin Inflammation in the Absence of Interleukin-17 Receptor A Signaling

Khalifa El Malki, Susanne Helena Karbach, Jula Huppert, Morad Zayoud et autres

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Pro-Inflammatory Effects of Interleukin-17A on Vascular Smooth Muscle Cells Involve NAD(P)H- Oxidase Derived Reactive Oxygen Species

Eweline Pietrowski, Bianca Bender, Jula Huppert, Robin White et autres

T cells are known for their contribution to the inflammatory element of atherosclerosis. Recently, it has been demonstrated that the Th17 derived cytokine IL-17 is involved in the pro-inflammatory response of vascular smooth muscle cells (VSMC). The aim of the present study …

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