Katharina H. Susek

Challenges in αCD38-chimeric antigen receptor (CAR)-expressing natural killer (NK) cell-based immunotherapy in multiple myeloma: Harnessing the CD38dim phenotype of cytokine-stimulated NK cells as a strategy to prevent fratricide

Maria Karvouni, Marcos Vidal-Manrique, Katharina H. Susek, Alamdar Hussain et autres

Background aims Adoptive cell therapy with chimeric antigen receptor (CAR)-expressing natural killer (NK) cells is an emerging approach that holds promise in multiple myeloma (MM). However, the generation of CAR-NK cells targeting CD38 is met with obstacles due to the expression of …

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HSV1716 Infects Multiple Myeloma Cells and Leads to CD138 Downregulation

Katharina H. Susek, Viktoria Flore, Maria Karvouni, Stephan Meinke et autres

Multiple myeloma (MM) is a plasma cell malignancy that accounts for approximately 10% of all hematological cancers. MM is classified as incurable due to a high relapse rate after the initial therapy and failure to achieve long-term minimal residual disease (MRD). Therefore, …

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Generation of NK cells with chimeric-switch receptors to overcome PD1-mediated inhibition in cancer immunotherapy

Katharina H. Susek, Ysabel Alessa Schwietzer, Maria Karvouni, Mari Gilljam et autres

Abstract Multiple myeloma (MM) is an incurable hematological cancer, in which immune checkpoint inhibition (ICI) with monoclonal antibodies (mAbs) has failed due to uncontrollable immune responses in combination therapies and lack of efficacy in monotherapies. Although NK cell-specific checkpoint targets such as …

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A tractable microscopy- and flow cytometry-based method to measure natural killer cell-mediated killing and infiltration of tumor spheroids

Ysabel Alessa Schwietzer, Katharina H. Susek, Ziqing Chen, Evren Alici et autres

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P-010: Exploring the feasibility of CD38-targeting CAR-NK therapy for multiple myeloma by harnessing features of cytokine-expanded NK cells

Maria Karvouni, Marcos Vidal-Manrique, Katharina H. Susek, Arnika Kathleen Wagner et autres

P-020: PD1-based chimeric-switch receptor expressing NK cells recover from immune checkpoint inhibition in cancer

Katharina H. Susek, Ysabel Schwietzer, Maria Karvouni, Mari Gilljam et autres

Improved survival in multiple Myeloma patients undergoing autologous stem cell transplantation is entirely in the standard cytogenetic risk groups

Gabriel Afram, Katharina H. Susek, Katarina Uttervall, Johanna Dehlsen Wersäll et autres

INTRODUCTION: Novel drugs and drug combinations have improved outcomes for multiple myeloma patients. However, subgroups of patients still have a poor progression-free survival (PFS) and overall survival (OS). In an attempt to identify how the novel drugs affect the outcome in standard-risk …

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Outcome of COVID‐19 in multiple myeloma patients in relation to treatment

Katharina H. Susek, Charlotte Gran, Hans‐Gustaf Ljunggren, Evren Alici et autres

COVID-19 has emerged as a global pandemic. Cancer patients have been reported to be at higher risk for adverse outcome of COVID-19. Studies are ongoing to decipher the risk factors and risk groups among cancer patients as well as strategies to refine …

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Combination of herpes-simplex based oncolytic viruses (HSV-OV) with natural killer (NK) cells in Multiple Myeloma

Katharina H. Susek, Stephan Meinke, Arnika Kathleen Wagner, Hans‐Gustaf Ljunggren et autres

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The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

Katharina H. Susek, Maria Karvouni, Evren Alici, Andreas Lundqvist

Chemokines govern leukocyte migration by attracting cells that express their cognate ligands. Many cancer types show altered chemokine secretion profiles, favoring the recruitment of pro-tumorigenic immune cells and preventing the accumulation of anti-tumorigenic effector cells. This can ultimately result in cancer immune …

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A treatment planning study of prone vs. supine positions for locally advanced rectal carcinoma

Sergiu Scobioala, Christopher Kittel, Philipp Niermann, Heidi Wolters et autres

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Bone marrow laminins influence hematopoietic stem and progenitor cell cycling and homing to the bone marrow

Katharina H. Susek, Éva Korpos, Jula Huppert, Chuan Wu et autres

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