Giovanni Scala

Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris Essential Oils in Cystitis: An Alternative/Complementary Perspective

Laura Mattioli, Ivan Corazza, Alberto Santini, Carla Marzetti et autres

Background/Objectives: Cystitis is a common lower urinary tract infection often associated with recurrence, bladder discomfort, and increasing antimicrobial resistance. Essential oils (Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris) are phytocomplexes with antimicrobial, antioxidant, and smooth muscle-modulating properties. Methods: The essential oils (contained …

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XRCC1 deficiency drives telomeric chromatin leakage, inflammatory signalling and senescence

Anna Piscone, Francesca Gorini, Susanna Ambrosio, Carmen Caiazza et autres

Genome integrity is constantly challenged by oxidative DNA damage, which, if left unrepaired, can result in replication stress, chromosomal instability, and tumorigenesis. The base excision repair (BER) pathway is essential for resolving oxidative base lesions such as 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). Among BER factors, …

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Thyme, Oregano, and Cinnamon Essential Oils: Investigating Their Molecular Mechanism of Action for the Treatment of Bacteria-Induced Cystitis

Emanuele Carosati, Laura Mattioli, Alberto Santini, Giovanni Caprioli et autres

Pathogen infections, exacerbated by emerging drug resistance, remain among the most challenging health issues, for which multitargeting approaches may offer effective solutions. In this context, medicinal plants, including essential oils, provide complex mixtures of diverse molecules that can exert therapeutic effects, either …

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Abstract 3237: Advancing non-invasive multiomics for early breast cancer detection: Transitioning from cfMeDIP-seq to single-molecule sequencing of cell-free DNA in the RENOVATE study

Martina Dameri, Francesco Ravera, Pamela Becherini, Mario Stabile et autres

Abstract Introduction: Tissue biopsy for suspicious breast lesions (BI-RADS 3-5) is invasive, costly, anxiety-inducing, and often yields false positives, with benign lesions (BLs) like fibroadenomas identified in approximately one-third of cases. Liquid biopsy, which analyzes the genomic and epigenomic features of cell-free …

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Bioactive Hydrogel Supplemented with Stromal Cell-Derived Extracellular Vesicles Enhance Wound Healing

Matteo Galbiati, Fabio Maiullari, Maria Grazia Ceraolo, Salma Bousselmi et autres

Background/Objectives: Skin regeneration is a rapidly advancing field with significant implications for regenerative medicine, particularly in treating wounds and burns. This study explores the potential of hydrogels functionalized with fibroblast-derived extracellular vesicles (EVs) to enhance skin regeneration in vivo. Being immunoprivileged, EVs …

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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy

Anna Piscone, Francesca Gorini, Susanna Ambrosio, Giovanni Scala et autres

Genomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in counteracting oxidative DNA damage caused by …

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MiDNE a tool for Multi-omics genes and drugs interactions discovery

Aurora Brandi, Barbara Majello, Ines Simeone, Michele Ceccarelli et autres

The availability of models representing molecular interactions in complex pathologies is essential for understanding their molecular setup and identifying therapeutic vulnerabilities. In this context, the advent of high-throughput technologies has enabled the rapid and cost-effective profiling of multiple omics layers, driving a …

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Author Correction: Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth

Rossella Delle Donne, Rosa Iannucci, Laura Rinaldi, Luca Roberto et autres

The original version of this Article contained a repetition of two images in Fig. 5f, in which the FACS plots for SANPs-siRNAc and SANPs-siPraja2 were identical. The correct version of Fig. 5 is:

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MoNETA: MultiOmics Network Embedding for SubType Analysis

Giovanni Scala, Luigi Ferraro, Aurora Brandi, Yan Guo et autres

Cells are complex systems whose behavior emerges from a huge number of reactions taking place within and among different molecular districts. The availability of bulk and single-cell omics data fueled the creation of multi-omics systems biology models capturing the dynamics within and …

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Protective role of cells and spores of Shouchella clausii SF174 against fructose-induced gut dysfunctions in small and large intestine

Anella Saggese, Valentina Barrella, Angela Di Porzio, Antonio Dario Troise et autres

The oral administration of probiotics is nowadays recognized as a strategy to treat or prevent the consequences of unhealthy dietary habits. Here we analyze and compare the effects of the oral administration of vegetative cells or spores of Shouchella clausii SF174 in …

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Mitochondrial metabolism and neuroinflammation in the cerebral cortex and cortical synapses of rats: effect of milk intake through DNA methylation

Giovanna Trinchese, Antonia Feola, Gina Cavaliere, Fabiano Cimmino et autres

Brain plasticity and cognitive functions are tightly influenced by foods or nutrients, which determine a metabolic modulation having a long-term effect on health, involving also epigenetic mechanisms. Breast milk or formula based on cow milk is the first food for human beings, …

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Contributors

Panagiotis G. Adamopoulos, Theolan Adimulam, Antonella Agodi, Abdollah Allahverdi et autres

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