Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris Essential Oils in Cystitis: An Alternative/Complementary Perspective
Rattachement africain : fr, it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background/Objectives: Cystitis is a common lower urinary tract infection often associated with recurrence, bladder discomfort, and increasing antimicrobial resistance. Essential oils (Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris) are phytocomplexes with antimicrobial, antioxidant, and smooth muscle-modulating properties. Methods: The essential oils (contained in the solid formulations) were tested against 30 samples obtained either from urine cultures or vaginal swabs, which showed either Escherichia coli or Enterococcus faecalis. Antibacterial activity was assessed by disk diffusion assay: the efficacy of ciprofloxacin was measured, as well as the efficacy of each oil, tested both alone and in combination with ciprofloxacin. Their effects on bladder function were evaluated ex vivo in isolated guinea pig bladder strips by analyzing spontaneous and KCl-induced contractility. Antioxidant activity was determined using the DPPH assay. Results: All three essential oils showed antibacterial activity against the tested clinical isolates, with different susceptibility profiles. Their combination with ciprofloxacin generally improved antibacterial responsiveness, including in isolates with reduced ciprofloxacin sensitivity. O. vulgare and T. vulgaris essential oils showed relevant spasmolytic activity against KCl-induced contraction, whereas C. zeylanicum displayed the strongest antioxidant activity and favorable modulation of spontaneous bladder contractility at low concentrations. A combined chemoinformatic and bioinformatic approach enabled the identification of potential interactions between multiple essential oil constituents and the biological pathways that ciprofloxacin is likely to target. Conclusions: These findings suggest that cinnamon, oregano and thyme essential oils may act as multitarget phytocomplexes with antibacterial, antioxidant and bladder-modulating properties. They may represent complementary candidates for cystitis management, although further mechanistic, formulation and safety studies are required.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Cinnamomum zeylanicum, Origanum vulgare, and Thymus vulgaris Essential Oils in Cystitis: An Alternative/Complementary Perspective
- Date Crossref
- 15/09/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Technologies pour la Santé pays non établi dans la noticeOrganisme public
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University of Bologna Department of Pharmacy and Biotechnology pays non établi dans la noticeUniversité ou école supérieure
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Bologna Research Area pays non établi dans la noticeStructure de recherche
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University of Siena Department of Life Sciences pays non établi dans la noticeUniversité ou école supérieure
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University of Trieste Department of Chemical and Pharmaceutical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Federico II University Hospital pays non établi dans la noticeÉtablissement de santé
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University of Naples Federico II pays non établi dans la noticeUniversité ou école supérieure
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Valsambro S.r.l. pays non établi dans la noticeInstitution
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University of Naples “Federico II” Biology Department pays non établi dans la noticeUniversité ou école supérieure
Technologies pour la Santé, Department of Pharmacy and Biotechnology — University of Bologna et Bologna Research Area, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.