David A. Scott

Response to comment on ‘2025 ADS/ANZCA/GESA/NACOS clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists’

Benjamin L Olesnicky, Samantha Hocking, David A. Scott, Matthew Remedios et autres

au (code pays fourni par la source)

Postoperative Delirium and Neurocognitive Disorders Associated With Inflammatory and Neuronal Injury Biomarkers: A Prospective, Longitudinal, Cohort Study

Kelly J. Atkins, Lis A. Evered, David A. Scott, James R. Hall et autres

BACKGROUND: Older adults undergoing surgery frequently experience postoperative delirium and postoperative neurocognitive disorders (NCD), but the neuropathophysiology of these conditions remains obscure. A postoperative inflammatory cascade with subsequent neuronal injury is one theory that requires further investigation. We report the incidence of …

au, us (code pays fourni par la source)

SA35 Disease-Free Survival as a Surrogate Endpoint for Overall Survival in Patients With Adjuvant Treatments for Completely Resected Stage I-III Non-Small Cell Lung Cancer: A Systematic Literature Review and Meta-Analyses

Juliane Schäfer, Anadi Mahajan, David A. Scott, Neil Hawkins et autres

ch, gb, us (code pays fourni par la source)

Filifactor alocis Pathogenicity Requires TLR2 and the Oral Microbiome

Aruna Vashishta, L Li, Sanjay Srivastava, Tina Sharma et autres

Enrichment of the oral microorganism Filifactor alocis is strongly associated with the progression of periodontitis. However, F. alocis is part of a complex dysbiotic microbial community, and the organism’s direct pathogenic potential remains uncharacterized. Using the oral gavage model of experimental periodontitis, …

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Delineation of global, absolutely essential and conditionally essential pangenomes of Porphyromonas gingivalis

Kendall S. Stocke, Gwyneth Lamont, Jinlian Tan, David A. Scott

Porphyromonas gingivalis is a Gram-negative, anaerobic oral pathobiont, an etiological agent of periodontitis and the most commonly studied periodontal bacterium. Multiple low passage clinical isolates were sequenced, and their genomes compared to several laboratory strains. Phylogenetic distances were mapped, a gene absence-presence …

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Synthesis and Characterization of a Sustained Nitric Oxide-Releasing Orthodontic Elastomeric Chain for Antimicrobial Action

Alec McDonald, Carly Warden, Jinlian Tan, Kellianne M. Piell et autres

The acidic byproducts of bacteria in plaque around orthodontic brackets contribute to white spot lesion (WSL) formation. Nitric oxide (NO) has antibacterial properties, hindering biofilm formation and inhibiting the growth of oral microbes. Materials that mimic NO release could prevent oral bacteria-related …

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Tobacco‐enhanced biofilm formation by Porphyromonas gingivalis and other oral microbes

Jinlian Tan, Gwyneth Lamont, David A. Scott

Microbial biofilms promote pathogenesis by disguising antigens, facilitating immune evasion, providing protection against antibiotics and other antimicrobials and, generally, fostering survival and persistence. Environmental fluxes are known to influence biofilm formation and composition, with recent data suggesting that tobacco and tobacco-derived stimuli …

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The transcriptomic response to cannabidiol of Treponema denticola , a phytocannabinoid‐resistant periodontal pathogen

Jinlian Tan, Gwyneth Lamont, Michael Sekula, HeeJue Hong et autres

AIM: The use of cannabis, which contains multiple antimicrobials, may be a risk factor for periodontitis. We hypothesized that multiple oral spirochetes would be phytocannabinoid-resistant and that cannabidiol (CBD) would act as an environmental stressor to which Treponema denticola would respond transcriptionally, …

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Author response for "Tobacco‐enhanced biofilm formation by Porphyromonas gingivalis and other oral microbes"

Jinlian Tan, Gwyneth Lamont, David A. Scott

Surgery outcomes in those with neurocognitive disorders

Brendan Silbert, David A. Scott, Lisbeth Evered

The prevalence of neurocognitive disorders is rapidly increasing in high-income countries as the population ages and the prevention and management of many other life-threatening diseases improves. In Australia, dementia (including Alzheimer's disease) is now the leading cause of death in females and …

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Tobacco smoke exacerbates Filifactor alocis pathogenicity

Mina M. Z. Iskander, Gwyneth Lamont, Jinlian Tan, Michele Pisano et autres

AIM: Filifactor alocis has recently emerged as a periodontal pathobiont that appears to thrive in the oral cavity of smokers. We hypothesized that identification of smoke-responsive F. alocis genes would provide insight into adaptive strategies and that cigarette smoke would enhance F. …

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The Antimicrobial Properties of Cannabis and Cannabis-Derived Compounds and Relevance to CB2-Targeted Neurodegenerative Therapeutics

HeeJue Hong, Lucy Sloan, Deepak Saxena, David A. Scott

Cannabinoid receptor 2 (CB2) is of interest as a much-needed target for the treatment or prevention of several neurogenerative diseases. However, CB2 agonists, particularly phytocannabinoids, have been ascribed antimicrobial properties and are associated with the induction of microbiome compositional fluxes. When developing …

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