Anadi Mahajan

A Systematic Review and Model‐Based Meta‐Analysis of Pegylated‐Interferon‐α‐Induced HBsAg Loss in Chronic Hepatitis B Virus Infection

Nathan Hanan, Matthew L. Zierhut, Ahmed M. Nader, Anadi Mahajan et autres

Pegylated-interferon-α (Peg-IFNα) is a treatment option for chronic hepatitis B virus (HBV) infection. To quantify treatment response variability, we conducted a model-based meta-analysis (MBMA) of hepatitis B surface antigen (HBsAg) loss, defined as a binary outcome based on HBsAg levels falling below …

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SA35 Disease-Free Survival as a Surrogate Endpoint for Overall Survival in Patients With Adjuvant Treatments for Completely Resected Stage I-III Non-Small Cell Lung Cancer: A Systematic Literature Review and Meta-Analyses

Juliane Schäfer, Anadi Mahajan, David A. Scott, Neil Hawkins et autres

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EE151 Conceptualizing an Economic Model Structure for Parkinson's Disease

Monica Ruoss, Anna Kotzeva, Anshul Shah, Saifuddin Kharawala et autres

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576PA systematic literature review: real-world motor function outcomes with risdiplam in treatment naïve adults with types 2 and 3 SMA

Ksenija Gorni, Calum D. Sutherland, E. T. Davies, Anadi Mahajan et autres

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Association of Hepatitis B Surface Antigen Levels With Long‐Term Complications in Chronic Hepatitis B Virus Infection: A Systematic Literature Review

Anadi Mahajan, Saifuddin Kharawala, Supriya Desai, Stuart F. W. Kendrick et autres

Chronic hepatitis B virus (HBV) infection is a global issue and can lead to cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B surface antigen (HBsAg) is an important marker of HBV infection and HBsAg quantification could be a useful tool in clinical practice. …

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Long-Term Comparative Efficacy and Safety of Risdiplam and Nusinersen in Children with Type 1 Spinal Muscular Atrophy

Christos Kokaliaris, Rachel Evans, Neil Hawkins, Anadi Mahajan et autres

Spinal muscular atrophy (SMA) is a severe genetic neuromuscular disease characterized by a loss of motor neurons and progressive muscle weakness. Children with untreated type 1 SMA never sit independently and require increasing levels of ventilatory support as the disease progresses. Without …

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The impact of varying levels of residual disease following cytoreductive surgery on survival outcomes in patients with ovarian cancer: a meta-analysis

Dana Meredith Chase, Anadi Mahajan, David Alexander Scott, Neil Hawkins et autres

BACKGROUND: Residual disease following cytoreductive surgery in patients with ovarian cancer has been associated with poorer survival outcomes compared with no residual disease. We performed a meta-analysis to assess the impact of varying levels of residual disease status on survival outcomes in …

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Red Blood Cell Transfusion Use in Dialysis-Dependent Patients with Anemia of CKD in the United States: A Systematic Literature Review

Anna A. Richards, Anadi Mahajan, Lakshmi R. Gajjala, Supriya C. Desai et autres

Background: Anemia of chronic kidney disease (aCKD) occurs frequently in dialysis-dependent (DD) patients (pts). Management includes iron supplementation, erythropoiesis-stimulating agents, and when clinically indicated, red blood cell transfusions (RBCT). There are limited collated data on RBCT use in the US; thus, a …

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Correlation between progression-free survival and overall survival in patients with ovarian cancer after cytoreductive surgery: a systematic literature review

Dana Meredith Chase, Anadi Mahajan, David Alexander Scott, Neil Hawkins et autres

Objectives This analysis aimed to better define the relationship between progression-free survival and overall survival in adult patients with ovarian cancer (including fallopian tube or primary peritoneal cancer) following primary cytoreductive surgery or interval cytoreductive surgery. Methods A systematic literature review was …

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#4424 FREQUENCY OF RED BLOOD CELL TRANSFUSION USE IN PATIENTS WITH ANEMIA OF CHRONIC KIDNEY DISEASE (CKD) IN EUROPE: A SYSTEMATIC LITERATURE REVIEW

Jake N. Hunnicutt, Anadi Mahajan, Ravalitha Gajjala, Saifuddin Kharawala et autres

Abstract Background and Aims Anemia of CKD is common and managed with oral or intravenous iron, erythropoiesis-stimulating agents (ESAs) and, when necessary, red blood cell transfusions (RBCT). Reducing RBCT use is a goal in the management of anemia of CKD due to …

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Model-based meta-analysis of pegylated IFN-alpha induced HBsAg loss at end of treatment and 24 weeks post treatment in chronic hepatitis B virus infection

Nathan Hanan, Matthew L. Zierhut, Ahmed M. Nader, Anadi Mahajan et autres

Hepatitis B surface antigen loss rate and safety and discontinuations with pegylated interferon alpha in chronic hepatitis B virus infection, a systematic review

Vera Gielen, Amandeep Kaur, Krishna G. Kumar, Saifuddin Kharawala et autres