Kellianne M. Piell

Regulation of PSAT1 and PHGDH by m6A in endocrine-resistant breast cancer cells

Kellianne M. Piell, Anna Vallarta, Ali E. Wilt, Bailey L Avila-Valdes et autres

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Long-Read Isoform Sequencing Reveals Aroclor1260-Induced Isoform Usage in Mouse Livers

Belinda J. Petri, Kellianne M. Piell, Banrida Wahlang, Chariker Julia et autres

Background/Objectives: Long-term exposure to polychlorinated biphenyls (PCBs), including the mixture of PCBs in Aroclor1260 (Ar1260), results in metabolic dysfunction-associated steatotic liver disease (MASLD) in mice and humans. While the effects of PCBs on gene expression are well-documented using short-read RNA sequencing, the …

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Integrated Nanopore and short-read RNA sequencing identifies dysregulation of METTL3- m6A modifications in endocrine therapy- sensitive and resistant breast cancer cells

Belinda J. Petri, Kellianne M. Piell, Bailey L Avila-Valdes, Christian G. Stanley et autres

The role of epitranscriptomic changes in the development of acquired endocrine therapy (ET)- resistance in estrogen receptor α (ER) expressing breast cancer (BC) is unknown. We tested the hypothesis that inhibition of METTL3, the methyltransferase responsible for the mRNA modification N-6 methyladenosine …

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Polychlorinated Biphenyl Exposure Alters tRNA Transcriptome in High-Fat Diet-Fed Mouse Liver

Carolyn M. Klinge, Julia H. Chariker, Kellianne M. Piell, Belinda J. Petri et autres

Background/Objectives: Exposure of high-fat diet (HFD)-fed mice to polychlorinated biphenyls (PCBs) results in metabolic dysfunction-associated steatotic liver disease (MASLD) and progression to metabolic dysfunction-associated steatohepatitis (MASH). The mechanisms by which HFD diet and PCBs increase MASLD are unclear. Previously, we identified differences …

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7232 Direct m6A mRNA-Seq in Endocrine- Resistant and Sensitive Breast Cancer Cells

Bart‐Jeroen Petri, B Valdés, Kellianne M. Piell, Eric Christian Rouchka et autres

Abstract Disclosure: B.J. Petri: None. B.L. Valdes: None. K.M. Piell: None. E.C. Rouchka: None. C.M. Klinge: None. Acquired resistance to endocrine therapies (ET) in patients with estrogen receptor α (ER+) breast tumors results in metastatic spread. RNA modifications including N6-methyladenosine (m6A) play …

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7232 Direct m6A mRNA-Seq In Endocrine- Resistant And Sensitive Breast Cancer Cells

Bart‐Jeroen Petri, B Valdés, Kellianne M. Piell, Eric Christian Rouchka et autres

Abstract Disclosure: B.J. Petri: None. B.L. Valdes: None. K.M. Piell: None. E.C. Rouchka: None. C.M. Klinge: None. Acquired resistance to endocrine therapies (ET) in patients with estrogen receptor α (ER+) breast tumors results in metastatic spread. RNA modifications including N6-methyladenosine (m6A) play …

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Integrated Metabolomics and Transcriptomics Analysis of Anacardic Acid Inhibition of Breast Cancer Cell Viability

Kellianne M. Piell, Claire C. Poulton, Christian G. Stanley, David J. Schultz et autres

Anacardic acid (AnAc) inhibits the growth of estrogen receptor α (ERα)-positive MCF-7 breast cancer (BC) cells and MDA-MB-231 triple-negative BC (TNBC) cells, without affecting primary breast epithelial cells. RNA sequencing (seq) and network analysis of AnAc-treated MCF-7 and MDA-MB-231 cells suggested that …

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Synthesis and Characterization of a Sustained Nitric Oxide-Releasing Orthodontic Elastomeric Chain for Antimicrobial Action

Alec C. McDonald, Carly Warden, Jinlian Tan, Kellianne M. Piell et autres

The acidic byproducts of bacteria in plaque around orthodontic brackets contribute to white spot lesion (WSL) formation. Nitric oxide (NO) has antibacterial properties, hindering biofilm formation and inhibiting the growth of oral microbes. Materials that mimic NO release could prevent oral bacteria-related …

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Abstract PO1-23-11: Differential m6A modification identified by direct RNA sequencing in endocrine- resistant and sensitive breast cancer cells

Belinda J. Petri, B Valdés, Kellianne M. Piell, Eric Christian Rouchka et autres

Abstract A major limitation of current adjuvant treatments for the ~ 70% of breast cancer patients with estrogen receptor α–expressing (ER+) primary breast tumors is the development of acquired and adaptive endocrine therapy (ET) resistance and metastatic spread. Chemical modifications of transcribed …

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Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease

Kellianne M. Piell, Belinda J. Petri, Jason J. Xu, Lu Cai et autres

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Identification of Factor XIII β-Sandwich Residues Mediating Glutamine Substrate Binding and Activation Peptide Cleavage

Rameesa D. Syed Mohammed, Kellianne M. Piell, Muriel C. Maurer

BACKGROUND: Factor XIII (FXIII) forms covalent crosslinks across plasma and cellular substrates and has roles in hemostasis, wound healing, and bone metabolism. FXIII activity is implicated in venous thromboembolism (VTE) and is a target for developing pharmaceuticals, which requires understanding FXIII - …

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Altered splicing factor and alternative splicing events in a mouse model of diet- and polychlorinated biphenyl-induced liver disease

Belinda J. Petri, Kellianne M. Piell, Banrida Wahlang, Kimberly Z. Head et autres

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