Sarah Juel Paulsen

Eight weeks of treatment with probiotic Bifidobacterium breve, Bif195 lowers fatigue scores in patients with diarrhoea-predominant irritable bowel syndrome: results from a randomised, clinical trial

Ida Marie Bruun Grønbæk, Sofie Ingdam Halkjær, Esben Holm Hansen, Sarah Mollerup et autres

Patients with irritable bowel syndrome experience abdominal pain and stool habit disturbances, and often also extraintestinal symptoms, such as fatigue. The disorder is linked to gut dysbiosis, and manipulation of the microbiota is considered a possible treatment strategy. This randomised, double-blinded, placebo-controlled …

dk (code pays fourni par la source)

Freezing of Vaginal Swabs Prior to DNA Purification Does Not Statistically Significantly Affect Microbiome Composition

Khaled Saoud Ali Ghathian, Julie Elm Heintz, Sarah Mollerup, Sarah Juel Paulsen et autres

Vaginal microbiome profiles may be affected by storage conditions, especially after human DNA depletion, yet systematic evaluations are limited. To assess the short-term impact of storage temperature on vaginal microbiome composition following host DNA depletion. Vaginal swabs were stored at 5°C (48 …

dk (code pays fourni par la source)

Deletion of GFRAL blunts weight lowering effects of FGF21 in female mice

Alberte Silke Buch-Rasmussen, Helle Andersen, Christina Stage, Ann Maria Kruse Hansen et autres

The role of the GDF15 receptor, GDNF family receptor alpha-like (GFRAL), in the metabolic effects of FGF21 was investigated by treating female GFRAL knockout mice with recombinant human FGF21. In contrast to FGF21-treated wild-type mice, which lost 12% body weight relative to …

dk, us (code pays fourni par la source)

Comparison of whole-genome sequencing-based analysis methods for taxonomic classification of isolates unclassified by MALDI-TOF MS

Sarah Mollerup, Sarah Juel Paulsen, Michael Pedersen, Henrik Westh

Taxonomic identification of clinical isolates is routinely achieved using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS). If the species cannot be reliably identified, whole-genome sequencing can be applied. The aim of this study was to compare the results of approaches …

dk (code pays fourni par la source)

Faecal sample storage without ethanol for up to 24 h followed by freezing performs better than storage with ethanol for shotgun metagenomic microbiome analysis in patients with inflammatory and non-inflammatory intestinal diseases and healthy controls

Ida Marie Bruun Grønbæk, Sarah Mollerup, Sofie Ingdam Halkjær, Sarah Juel Paulsen et autres

OBJECTIVE: The influence of different faecal collection methods on metagenomic analyses remains under discussion, and there is no general agreement on which collection method is preferable for gut microbiome research. We compared faecal samples collected in tubes without preservatives with those containing …

dk (code pays fourni par la source)

High-resolution epidemiological landscape from ~290,000 SARS-CoV-2 genomes from Denmark

Mark P. Khurana, Jacob Liam Curran-Sebastian, Neil Scheidwasser, Christian Morgenstern et autres

Vast amounts of pathogen genomic, demographic and spatial data are transforming our understanding of SARS-CoV-2 emergence and spread. We examined the drivers of molecular evolution and spread of 291,791 SARS-CoV-2 genomes from Denmark in 2021. With a sequencing rate consistently exceeding 60%, …

dk, gb, au, ch (code pays fourni par la source)

The microbiome of the appendix differs in patients with and without appendicitis: A prospective cohort study

Siv Fonnes, Sarah Mollerup, Sarah Juel Paulsen, Barbara Juliane Holzknecht et autres

dk (code pays fourni par la source)

A genetic map of the mouse dorsal vagal complex and its role in obesity

Mette Q. Ludwig, Wenwen Cheng, Desiree Gordian, Julie Lee et autres

dk, us (code pays fourni par la source)

It Takes Two Generations to Forget

Sarah Juel Paulsen

Sarah Paulsen, It Takes Two Generations to Forget, 2017. Collage and colored pencil on paper, 15 × 22 in. This piece is part of Paulsen's series “White Ghosts,” a two-year exploration of whiteness. “During a meeting of Witnessing Whiteness, I asked the …

Semaglutide lowers body weight in rodents via distributed neural pathways

Sanaz Gabery, Casper Graversen Salinas, Sarah Juel Paulsen, Jonas Ahnfelt‐Rønne et autres

Semaglutide, a glucagon-like peptide 1 (GLP-1) analog, induces weight loss, lowers glucose levels, and reduces cardiovascular risk in patients with diabetes. Mechanistic preclinical studies suggest weight loss is mediated through GLP-1 receptors (GLP-1Rs) in the brain. The findings presented here show that …

hu, dk, us, fr (code pays fourni par la source)

GFRAL is the receptor for GDF15 and is required for the anti-obesity effects of the ligand

Linda G. Yang, Chih-Chuan Chang, Zhe Sun, Dennis Madsen et autres

dk (code pays fourni par la source)

Effect of Roux-en-Y gastric bypass on the distribution and hormone expression of small-intestinal enteroendocrine cells in obese patients with type 2 diabetes

Nicolai Alexander Rhee, Camilla D. Wahlgren, Jens Pedersen, Brynjulf Mortensen et autres

dk (code pays fourni par la source)