Iraj Alipourfard

DNA Origami Nanostructures as Programmable Nanobots for Targeted Drug Delivery, Stimuli-Responsive Release, and Cancer Theranostics: Design, Functionalization and Translational Challenges

Delsuz Rezaee, Iraj Alipourfard, Ali Noori-Zadeh

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Advances in metal-organic frameworks (MOFs) for nanotheranostics: from targeted drug delivery to multimodal imaging

Shiva Velayati, Masoumeh Zahmatkeshan, Naghmeh Farzaneh, Fariba Esmaeili et autres

The integration of diagnostic and therapy into a single nanoplatform has been proved to be a revolutionary approach for precision medicine, which allows the simultaneous disease detection, treatment, and therapeutic monitoring. Although great progress has been achieved in nanotheranostics, many traditional nanomaterials …

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Cell Therapy as Metabolic Rescue after Ischemic Stroke: Rewiring Bioenergetics, Redox Homeostasis, and Neurovascular Repair

Salar Bakhtiyari, Iraj Alipourfard

Ischemic stroke represents a dynamic metabolic disorder of the neurovascular unit (NVU) rather than a static vascular occlusion followed by neuronal demise. Immediate oxygen and glucose deprivation rapidly deplete ATP, disrupt the transmembrane ionic gradients, increase glutamate excitotoxicity, and overload mitochondrial with …

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Functionalized metal-organic frameworks as smart nanoplatforms: advancing tumor precision therapy through post-synthetic surface tailoring, challenges, and prospects for clinical translation

Shiva Velayati, Masoumeh Zahmatkeshan, Fariba Esmaeili, Seyed Mohammad Hosseini et autres

Metal–organic frameworks (MOFs) have garnered significant attention as versatile nanocarriers for oncological drug delivery, owing to their exceptional porosity, structural tunability, extensive specific surface areas, and favorable drug loading and release kinetics, which collectively enable targeted payload delivery and reduced systemic toxicity. …

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Multifunctional Nano-Contrast Agent Carriers: From Traditional Platforms to Next-Generation Theranostic Applications in Molecular Imaging

Danial Mirzaee, Marzieh Ramezani Farani, Maryam Ghasemzaei, Amir Gholami et autres

Multifunctional nano-contrast agent carriers are redefining molecular imaging by combining high-fidelity visualization with targeted delivery, controlled release, and, increasingly, therapeutic action. This review encompasses the development of nano-contrast platforms from conventional dendrimer, liposome, chitosan, and silica systems to modular nano-contrast platforms for …

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Advances in Proteomics for Breast Cancer: Bridging Biomarker Discovery and Clinical Application

Farhood Ghazi, Ahmad Mobed, Vahid Alivirdiloo, Mobasher Hajiabbasi et autres

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Emerging Applications of CAR-T Cell Therapy in Overcoming Resistance and Expanding Targets in Hematologic Malignancies: Insights from Recent Research

Iraj Alipourfard, Zahra Shafaghat, Saber Saharkhiz, Marzieh Ramezani Farani et autres

Chimeric antigen receptor T-cell (CAR-T) therapy has revolutionized the treatment outcomes of patients with hematologic malignancies, including B-cell acute lymphoblastic leukemia (B-ALL), diffuse large B-cell lymphoma (DLBCL), and multiple myeloma (MM). However, issues such as antigen escape, T-cell exhaustion, and the limited …

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Circular RNAs in tumorigenesis: an insight into recent research in biogenesis and targeted tumor therapy

Zahra Shafaghat, Pezhman Golshanrad, Saber Saharkhiz, Anna Leśniak et autres

Circular RNAs (circRNAs) are eukaryotic RNA molecules that are covalently closed and have the characteristics of high stability, tissue-specific expression, and cell-specific expression. The majority of circRNAs are produced from pre-mRNAs that also result in linear RNA, and they have expression patterns …

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The protective role of µ- and δ-opioid receptor blockage on memory deficits after mild traumatic brain injury is dependent on preexisting high endogenous opioid tone

Justyna Paszkiewicz, Patrycja Andrzejuk, Piotr Poznański, Kaja Śmietanka et autres

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Programmable lipid nanoparticles for RNA therapeutics: Design principles and clinical translation

Mahdi Navid Talemi, Marzieh Ramezani Farani, Naiyereh Alipour Eskandani, Danial Mirzaee et autres

RNA therapeutics have come of age as clinically validated modalities including mRNA, siRNA, antisense oligonucleotides (ASOs), and in vivo genome editing, with lipid nanoparticles (LNPs) as the main non-viral delivery system. This review defines programmable LNPs as systems whose composition and interfacial …

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Immunomodulatory Agents and Factors in Poor Hematopoietic Stem Cell Mobilization: Current Strategies and Future Prospects

Iraj Alipourfard, Tahere Mokhtari, Anna Leśniak, Saber Saharkhiz et autres

Hematopoietic stem cell (HSC) mobilization is a critical step in bone marrow transplantation for treating hematological malignancies and other disorders. Since poor mobilization affects 10–20% of patients, it can cause failure of the transplant and complications in clinical outcomes. There are several …

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Microfluidics devices for metabolic disorders

Iraj Alipourfard

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