Gregory T. Tietjen

Cell Death in Mouse Kidneys during Cold Ischemia Shows Sexual Dimorphism and Can Be Delayed by a Bax Inhibitor

S. Liburd, Jenna DiRito, Sarah Wong, K. Van Tassel et autres

Purpose: The risk of delayed graft function of human kidney allografts increases with time of cold ischemia. An analysis of biopsies from human kidneys declined for transplant revealed increasing renal cell death with increasing cold storage time, but interpretation is complicated by …

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Research Exclusive Donation: Revolutionizing Medical Research through Organ Procurement Organizations

C. A. Hostetler, Richard A. Squires, L.W. Glenn, María Florencia Fernández et autres

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Identifying Failure Modes of Pancreatic Islet Cells during Cold Storage Using a Multi-Omics Approach

Nabil E. Boutagy, Lorna Glenn, Bill Nave, O. Severinchik et autres

Purpose: Pancreas transplantation is a curative solution for patients with Type 1 Diabetes. However, less than 1000 pancreas transplantations are conducted each year due to a lack of suitable organs. Approximately 30% of pancreases procured from deceased donors in the United States …

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Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study

Alborz Feizi, Jenna DiRito, Owen Richfield, John C. Stendahl et autres

BACKGROUND: Ex vivo perfusion of transplant-declined human organs has emerged as a promising platform to study the response of an organ to novel therapeutic strategies. However, to fully realize the capability of this platform for performing translational research in human organ pathophysiology, …

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An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver

Jain Jeong, Masatake Tanaka, Yilin Yang, Nikolai Arefyev et autres

This article showed a comprehensive 3-D-structural analysis of liver lymphatic vessel (LV) in normal and diseased livers in relation to blood vessels and bile ducts. In addition to the LVs highly localized at the portal tract, we revealed capsular LVs in mouse, …

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Honoring the gift: The transformative potential of transplant-declined human organs

Claire Albert, Matthew Harris, Jenna DiRito, Audrey A. Shi et autres

For decades, transplantation has been a life-saving treatment for those fortunate enough to gain access. Nevertheless, many patients die waiting for an organ and countless more never make it onto the waitlist because of a shortage of donor organs. Concurrently, thousands of …

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Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Claire Albert, Laura G. Bracaglia, Akiko Koide, Jenna DiRito et autres

Vascular endothelial cells (ECs) play a central role in the pathophysiology of many diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could dramatically improve efficacy by providing elevated and sustained intracellular drug levels. However, achieving sufficient levels of …

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Blood Transcriptomes of SARS-CoV-2–Infected Kidney Transplant Recipients Associated with Immune Insufficiency Proportionate to Severity

Zeguo Sun, Zhongyang Zhang, Khadija Banu, Yorg Al Azzi et autres

Background Among patients with COVID-19, kidney transplant recipients (KTRs) have poor outcomes compared with non-KTRs. To provide insight into management of immunosuppression during acute illness, we studied immune signatures from the peripheral blood during and after COVID-19 infection from a multicenter KTR …

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Cellular recovery after prolonged warm ischaemia of the whole body

David Andrijević, Zvonimir Vrselja, Taras Lysyy, Shupei Zhang et autres

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Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs

Samuel Liburd, Audrey A. Shi, Jordan S. Pober, Gregory T. Tietjen

Despite the profound shortage of organs available for transplant in the U.S., over 5,000 donated organs were declined for use in 2020. Many of these organs were declined due to donor comorbidities or preservation injuries that predispose grafts to rejection and loss. …

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Revisiting the Principles of Preservation in an Era of Pandemic Obesity

John Langford, Jenna DiRito, Natty Doilicho, Graylen R. Chickering et autres

The current obesity epidemic has caused a significant decline in the health of our donor population. Organs from obese deceased donors are more prone to ischemia reperfusion injury resulting from organ preservation. As a consequence, these donors are more likely to be …

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Nanotherapeutics in transplantation: How do we get to clinical implementation?

Leah Plumblee, Carl Atkinson, Dinesh Jaishankar, Evan A. Scott et autres

Patients undergoing organ transplantation transition from one life-altering issue (organ dysfunction) to a lifelong commitment-immunosuppression. Regimens of immunosuppressive agents (ISAs) come with significant side effects and comorbidities. Recently, the use of nanoparticles (NPs) as a solution to the problems associated with the …

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