Jenna DiRito

SRS237 - Inhibition of the NLRP3 inflammasome improves functional outcomes and decreases expression of the inflammatory cytokines IL-1b and IL-18 during normothermic machine perfusion of human kidneys

Maulik Mehta, Jenna DiRito, Serena MacMillan, Sarah A. Hosgood et autres

Abstract Background Assembly and activation of the NLRP3 inflammasome is a critical mechanism in renal ischaemia reperfusion injury (IRI). NLRP3 activation leads to caspase-1 dependent release of the pro-inflammatory cytokines IL-1b and IL-18 and pyroptotic cell death. This study investigates the effects …

gb, us (code pays fourni par la source)

Integrated AAV optimization enables efficient gene delivery to kidney in murine and human tissue

Fernando Gómez García, Shashank Chetty, Najani Shanee Johnson, Andrea An et autres

in, es, us (code pays fourni par la source)

Cell Death in Mouse Kidneys during Cold Ischemia Shows Sexual Dimorphism and Can Be Delayed by a Bax Inhibitor

S. Liburd, Jenna DiRito, Sarah Wong, K. Van Tassel et autres

Purpose: The risk of delayed graft function of human kidney allografts increases with time of cold ischemia. An analysis of biopsies from human kidneys declined for transplant revealed increasing renal cell death with increasing cold storage time, but interpretation is complicated by …

us, sg (code pays fourni par la source)

Research Exclusive Donation: Revolutionizing Medical Research through Organ Procurement Organizations

C. A. Hostetler, Richard A. Squires, L.W. Glenn, María Florencia Fernández et autres

us, gb, in (code pays fourni par la source)

Identifying Failure Modes of Pancreatic Islet Cells during Cold Storage Using a Multi-Omics Approach

Nabil E. Boutagy, Lorna Glenn, Bill Nave, O. Severinchik et autres

Purpose: Pancreas transplantation is a curative solution for patients with Type 1 Diabetes. However, less than 1000 pancreas transplantations are conducted each year due to a lack of suitable organs. Approximately 30% of pancreases procured from deceased donors in the United States …

us (code pays fourni par la source)

Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study

Alborz Feizi, Jenna DiRito, Owen Richfield, John C. Stendahl et autres

BACKGROUND: Ex vivo perfusion of transplant-declined human organs has emerged as a promising platform to study the response of an organ to novel therapeutic strategies. However, to fully realize the capability of this platform for performing translational research in human organ pathophysiology, …

us, gb (code pays fourni par la source)

An optimized visualization and quantitative protocol for in-depth evaluation of lymphatic vessel architecture in the liver

Jain Jeong, Masatake Tanaka, Yilin Yang, Nikolai Arefyev et autres

This article showed a comprehensive 3-D-structural analysis of liver lymphatic vessel (LV) in normal and diseased livers in relation to blood vessels and bile ducts. In addition to the LVs highly localized at the portal tract, we revealed capsular LVs in mouse, …

us, jp (code pays fourni par la source)

Honoring the gift: The transformative potential of transplant-declined human organs

Claire Albert, Matthew Harris, Jenna DiRito, Audrey A. Shi et autres

For decades, transplantation has been a life-saving treatment for those fortunate enough to gain access. Nevertheless, many patients die waiting for an organ and countless more never make it onto the waitlist because of a shortage of donor organs. Concurrently, thousands of …

us, gb (code pays fourni par la source)

Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Claire Albert, Laura G. Bracaglia, Akiko Koide, Jenna DiRito et autres

Vascular endothelial cells (ECs) play a central role in the pathophysiology of many diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could dramatically improve efficacy by providing elevated and sustained intracellular drug levels. However, achieving sufficient levels of …

us, gb (code pays fourni par la source)

Surface conjugation of antibodies improves nanoparticle uptake in bronchial epithelial cells

Valerie L. Luks, Hanna K. Mandl, Jenna DiRito, Christina Barone et autres

BACKGROUND: Advances in Molecular Therapy have made gene editing through systemic or topical administration of reagents a feasible strategy to treat genetic diseases in a rational manner. Encapsulation of therapeutic agents in nanoparticles can improve intracellular delivery of therapeutic agents, provided that …

us (code pays fourni par la source)

Revisiting the Principles of Preservation in an Era of Pandemic Obesity

John Langford, Jenna DiRito, Natty Doilicho, Graylen R. Chickering et autres

The current obesity epidemic has caused a significant decline in the health of our donor population. Organs from obese deceased donors are more prone to ischemia reperfusion injury resulting from organ preservation. As a consequence, these donors are more likely to be …

us (code pays fourni par la source)

Comparative evaluation of glomerular morphometric techniques reveals differential technical artefacts between FSGS and normal glomeruli

John M. Basgen, Anand Reghuvaran, Qisheng Lin, Khadija Banu et autres

Abstract Morphometric estimates of mean glomerular volume (MGV) have clinical implications, over and above histologic data. However, MGV estimation is time-consuming, could waste tissue sections and requires expertise limiting its utility in retrospective clinical studies. Methods We evaluated MGV using both plastic …

us, cn (code pays fourni par la source)