Taras Lysyy

Intramyocardial Hydrogel Delivery Decreases Left Ventricular Remodeling and Increases Angiogenesis Post Myocardial Infarction

Inga Hlíf Melvinsdóttir, Dan E. Midgett, Shin-Rong Lee, Stephanie Thorn et autres

BACKGROUND: Intramyocardial injection of hydrogel into myocardial infarction (MI) areas can reduce left ventricular remodeling and potentially increase angiogenesis post-MI. The radiotracer 99m Tc-Maraciclatide binds to activated alpha-v-beta-3 (αvβ3)-integrin, a key factor in angiogenesis, and can be used to evaluate myocardial angiogenesis. …

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Using Foundation Models as Pseudo-Label Generators for Pre-Clinical 4D Cardiac CT Segmentation

Anne-Marie Rickmann, Stephanie Thorn, Shawn S. Ahn, Supum Lee et autres

Cardiac image segmentation is an important step in many cardiac image analysis and modeling tasks such as motion tracking or simulations of cardiac mechanics. While deep learning has greatly advanced segmentation in clinical settings, there is limited work on pre-clinical imaging, notably …

Surgical treatment of atrial fibrillation in coronary artery bypass grafting

Sarah M. Nisivaco, Taras Lysyy, Jane T. Kruse, James L. Cox et autres

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Using Foundation Models as Pseudo-label Generators for Pre-clinical 4D Cardiac CT Segmentation

Anne-Marie Rickmann, Stephanie Thorn, Shawn S. Ahn, Supum Lee et autres

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Abstract 4144104: Intramyocardial Hydrogel Injections in Porcine Model of Infarction Remodeling Demonstrates Improved Left Ventricular Performance on Pressure-Volume Analysis Associated with Decreased Matrix Metalloproteinase Activation

Olivia Porcaro, Stephanie Thorn, Shawn S. Ahn, Supum Lee et autres

Introduction: Following myocardial infarction (MI), extracellular matrix (ECM) degradation significantly contributes to adverse left ventricular (LV) remodeling mediated by the activation of matrix metalloproteinases (MMPs). Intramyocardial injection of hydrogels that locally release MMP inhibitors are designed to modulate MMP activation, increase wall …

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Contrast‐enhanced computed tomography for ex vivo assessment of human kidneys: A proof‐of‐concept study

Alborz Feizi, Jenna R. DiRito, Owen Richfield, John C. Stendahl et autres

BACKGROUND: Ex vivo perfusion of transplant-declined human organs has emerged as a promising platform to study the response of an organ to novel therapeutic strategies. However, to fully realize the capability of this platform for performing translational research in human organ pathophysiology, …

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Honoring the gift: The transformative potential of transplant-declined human organs

Claire Albert, Matthew A Harris, Jenna R. DiRito, Audrey A. Shi et autres

For decades, transplantation has been a life-saving treatment for those fortunate enough to gain access. Nevertheless, many patients die waiting for an organ and countless more never make it onto the waitlist because of a shortage of donor organs. Concurrently, thousands of …

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Monobody adapter for functional antibody display on nanoparticles for adaptable targeted delivery applications

Claire Albert, Laura G. Bracaglia, Akiko Koide, Jenna R. DiRito et autres

Vascular endothelial cells (ECs) play a central role in the pathophysiology of many diseases. The use of targeted nanoparticles (NPs) to deliver therapeutics to ECs could dramatically improve efficacy by providing elevated and sustained intracellular drug levels. However, achieving sufficient levels of …

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Cellular recovery after prolonged warm ischaemia of the whole body

David Andrijević, Zvonimir Vrselja, Taras Lysyy, Shupei Zhang et autres

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CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel

Dan E. Midgett, Stephanie Thorn, Shawn S. Ahn, Selen Uman et autres

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L-arginine prevents ischemic injury in explanted rat intestinal regions in an ex vivo perfusion model

Michele Finotti, María José Barahona, Renee M. Maina, Taras Lysyy et autres

The small intestine is one of the most sensitive organs to ischemia. L-arginine has been shown to reduce damage from ischemia and reperfusion injury. We hypothesize that explanted intestinal segments from rats will demonstrate reduced susceptibility to ischemic injury when perfused with …

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Abstract 14327: Intramyocardial Delivery of an Imageable Theranostic Hydrogel Post Myocardial Infarction Alters Regional Strain and Reduces Remodeling in Chronic Porcine Model

Inga Hlíf Melvinsdóttir, Dan E. Midgett, Shin-rong Lee, Selen Uman et autres

Introduction: Myocardial infarction (MI) causes acute regional changes in stiffness and strain, resulting in pathological remodeling in the left ventricle (LV). Intramyocardial injection of hydrogel (HG) into the MI region may alter deformation and improve LV remodeling. Using high resolution cineCT (CCT) …

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