Evan Alexander Scott

PROX1 loss in adult mouse Schlemm’s canal causes permanent ocular hypertension

Sofia Lara Ochoa, Hoi‐Lam Li, Hyeohn Kim, Natalia C Mendonca et autres

Glaucoma is associated with ocular hypertension and lowering intraocular pressure is a key objective of glaucoma therapies. Recent studies have established a role for the Schlemm's canal endothelium in this pressure increase and have shown it to have a unique, lymphatic-like, hybrid …

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Cytosolic Delivery of a Bithiophene Derivative via Polymersomes Kills Trypanosoma cruzi Amastigotes and Modulates the Inflammatory Response

Rayanne Regina Beltrame Machado, Débora B. Scariot, Amanda Beatriz Kawano Bakoshi, El Hadji Arona Mbaye et autres

High Resolution Image Download MS PowerPoint Slide Chagas disease, caused by the protozoan Trypanosoma cruzi, is an infectious illness that progresses through acute, indeterminate, and chronic phases. The acute phase often presents mild symptoms, followed by an asymptomatic indeterminate phase. In some …

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Filomicelle‐Embedded Composite Hydrogels for Localized Gelation Within the Anterior Chamber of the Eye

Hyeohn Kim, Sofia Lara Ochoa, Swagat Sharma, Asmaa A Youssif et autres

Anterior segment diseases, including glaucoma and uveitis, affect millions of patients worldwide. Nanocarriers hold transformative potential for treating these conditions, yet corneal epithelium impermeability necessitates intraocular injection. Given the discomfort and infection risk, an injectable hydrogel-based depot offers a promising strategy for …

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Engineering the Size of Bicontinuous Nanospheres via Multi-Inlet Vortex Mixing

Sultan Almunif, Simseok A. Yuk, El Hadji Arona Mbaye, Swagat Sharma et autres

High Resolution Image Download MS PowerPoint Slide Bicontinuous nanospheres (BCNs) are self-assembled nanostructures with interconnected aqueous channels that enable the coloading of hydrophilic and hydrophobic cargo; however, their size has been difficult to control. Here, we present a scalable approach to tune …

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Ultrasound-responsive nanoparticles: Modulating the tumor microenvironment to advance cancer immunotherapy

Gan Lin, Kangping Du, Drew Landrowski, Richard J. Price et autres

Cancer immunotherapy is a proven strategy against solid tumors, but its efficacy is often hindered by the immunosuppressive tumor microenvironment (TME) and immune-related side effects. Ultrasound-responsive nanoparticles (URNs) offer a precise strategy to activate immunomodulators at targeted sites, enhancing efficacy while reducing …

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Subcutaneous nanotherapy for islet transplantation preserves functional protective immunity in a staphylococcus aureus skin infection model 2717

El Hadji Arona Mbaye, Débora B. Scariot, Amanda Beatriz Kawano Bakoshi, N. Klug et autres

Abstract Description The approval of Lantidra, the first cellular therapy for type 1 diabetes, is a milestone for islet transplantation (TX), offering an alternative to insulin therapy. However, TX adoption is constrained by the need for systemic immunosuppression, which heightens nosocomial infection …

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Polymeric Nanocarriers Delay the Onset of Type 1 Diabetes in Nonobese Diabetic (NOD) Mice 2365

N. Klug, El Hadji Arona Mbaye, Jacqueline A. Burke, Drew Landrowski et autres

Abstract Description Introduction Teplizumab (Anti-CD3) is the first FDA-approved therapy to delay the onset of type 1 diabetes (T1D) and prolong insulin independence. However, this therapy comes with a high price tag and immunosuppressive adverse effects. We have previously demonstrated that rapamycin-loaded …

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Linking autophagy to endothelial cell immunogenicity in transplant-associated ischemia-reperfusion injury

Meredith E. Taylor, Dinesh Jaishankar, Krishnaraju Madavaraju, Simseok A. Yuk et autres

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Active Transport of Macrocycles into Micelles Using Molecular Pumps

James S. W. Seale, Swagat Sharma, Christopher Keith Lee, Han Han et autres

During the past decade, researchers have designed and synthesised a variety of artificial molecular pumps capable of the active transport of macrocycles (rings) from free solution into mechanically interlocked states. In their ability to drive non-equilibrium transport, these artificial molecular pumps imitate …

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Active Transport of Macrocycles into Micelles Using Molecular Pumps

James S. W. Seale, Swagat Sharma, Christopher Keith Lee, Han Han et autres

Abstract During the past decade, researchers have designed and synthesised a variety of artificial molecular pumps capable of the active transport of macrocycles (rings) from free solution into mechanically interlocked states. In their ability to drive non‐equilibrium transport, these artificial molecular pumps …

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Filomicelle-Embedded Composite Hydrogels for Localized Gelation within the Anterior Chamber of the Eye

Hyeohn Kim, Sofia Lara Ochoa, Swagat Sharma, Asmaa A Youssif et autres

Nanocarriers hold transformative potential for treating anterior segment eye diseases, yet corneal epithelium impermeability necessitates intraocular injection. Given the discomfort and infection risk, an injectable hydrogel-based depot offers a promising strategy for sustained nanocarrier delivery in intraocular therapy. However, because the aqueous …

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Enabling Organ- and Injury-Specific Nanocarrier Targeting via Surface-Functionalized PEG-b-PPS Micelles for Acute Kidney Injury

Boaz Bishop, Ratnakar Tiwari, Simseok A. Yuk, Sultan Almunif et autres

While nanomedicine holds great promise for kidney disease, targeted delivery remains a major challenge. Most nanocarriers rely on passive accumulation or epithelial-specific ligands, limiting their utility in complex, inflamed renal environments. In acute kidney injury (AKI), inflammation and vascular dysfunction play central …

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