Seon‐Kyu Kim

Primary tumor transcriptomic signature is associated with locoregional dissemination in canine mammary carcinoma

Jin-Hyuk Park, Jun-Yeol Choi, Se‐Hoon Kim, Ki-Hoon Song et autres

Abstract Canine mammary carcinoma (CMC) exhibits heterogeneous metastatic behavior, while accurate assessment of locoregional dissemination may be limited by incomplete sampling, occult metastasis, and variable sentinel lymph node anatomy. We investigated whether primary-tumor transcriptomic programs are associated with locoregional dissemination. The training …

kr, Éthiopie, ch (code pays fourni par la source)

Comparative analysis of urinary, bladder tissue, and stool microbiota in bladder cancer using shotgun metagenomics

Kyungchan Min, Chuang-Ming Zheng, Yanghyun Joo, Sujeong Kim et autres

Urine has been investigated as a less invasive biomarker source for bladder cancer (BCa) because of its direct contact with the bladder mucosa. Urine is assumed to reflect tissue microbiota, but most prior studies relied on 16S rRNA gene sequencing and contamination-prone …

kr (code pays fourni par la source)

Pharmacological Blockade of NMUR2 Suppresses Glioma Growth by Inhibiting STAT5-Mediated Transcription of Cell Cycle-associated Genes

Yuna Roh, Taesang Son, Tae-Hee Han, Sarang Kim et autres

. In addition, combination treatment with TMZ produced synergistic anti-tumor effects in glioma models. Collectively, our findings define a previously unrecognized NMUR2/Gαq/STAT5/PIM1-FOXM1 signaling axis in glioma and support pharmacological inhibition of NMUR2 as a potential therapeutic strategy.

kr (code pays fourni par la source)

Quantum computing-assisted validation of a conserved macrophage suppression module shared by ASFV and PEDV

Jongwon Byun, Hakjin Kim, Changhee Chandler Pyo, Kwang-Eun Choi et autres

ch, kr, us (code pays fourni par la source)

Discovery and Pharmacological Characterization of a Dual-Acting 2-Amino-3-Cyanopyridine Inhibitor Targeting Microtubule Polymerization and GAK

Seong-Jin Park, Eun Yeong Kim, Ji-Eun Lee, Ahra Go et autres

Microtubules are critical regulators of mitotic progression and cancer cell proliferation. Herein, we report a novel 2-amino-3-cyanopyridine-based scaffold that functions as a dual inhibitor of tubulin polymerization and cyclin G-associated kinase (GAK). Structure-activity relationship (SAR) optimization identified KMG-732 with nanomolar to submicromolar …

us, it, kr, cn (code pays fourni par la source)

Therapy-Driven Molecular Evolution of Bladder Cancer: Roles of Cellular Plasticity and Tumor Microenvironment

Seung-Woo Baek, Seo-Young Yoon, Seon‐Kyu Kim, Sun-Hee Leem

Drug resistance remains a significant barrier to achieving durable treatment responses. Traditionally, resistance has been attributed to genetic alterations and clonal selection. However, accumulating evidence suggests that early adaptation to therapy is often mediated by non-genetic state transitions. In this review, we …

kr (code pays fourni par la source)

Digital twins for plant–microbe interactions: Gap finding and filling

Seonghan Jang, Seon‐Kyu Kim, Jin‐Soo Son, Choong‐Min Ryu

kr (code pays fourni par la source)

Virtual lab of artificial intelligence agents accelerating nanobody design against SARS-CoV-2 variants

Hak-Jin Kim, Taeho Kwon, Sun‐Uk Kim, Seon‐Kyu Kim

Artificial intelligence (AI)-driven research frameworks are reshaping the boundaries of biomedical discovery. The Virtual Lab exemplifies this transformation, assembling large language model (LLM) agents into coordinated scientific teams functioning as investigators, specialists, and critics. The system autonomously designed, scored, and refined nanobody …

ch, kr (code pays fourni par la source)

RETRACTED: Pharmacological blockade of NMUR2 suppresses the growth of human glioma cells in vivo through the inhibition of STAT5-mediated transcriptional activation of cell-cycle associated genes

Yuna Roh, Taesang Son, Sarang Kim, Eunsun Jung et autres

kr (code pays fourni par la source)

Deep learning-driven whole-slide image analysis predicts chemo-resistance and motility subtypes in muscle-invasive bladder cancer

In Gab Jeong, Seung‐Jin Park, Seon Young Kim, Seon‐Kyu Kim et autres

kr (code pays fourni par la source)

IC2Bert: masked gene expression pretraining and supervised fine tuning for robust immune checkpoint blockade (ICB) response prediction

Seongyong Park, Seon‐Kyu Kim, Peng Jiang

Bulk RNA-seq-based prediction of immune checkpoint blockade (ICB) responses has been extensively studied to distinguish responders from non-responders. However, cohort heterogeneity remains a major challenge, hindering the robustness and generalizability of predictive models across diverse RNA-seq datasets. In this study, we present …

us, kr (code pays fourni par la source)

Prognostic and therapeutic value of a 23-gene risk score tailored to the molecular characteristics of mucinous colorectal cancer

Jae‐Yoon Kim, Ye Jin Ha, Ka Hee Tak, Jeong‐Hwan Kim et autres

kr (code pays fourni par la source)