Chuang-Ming Zheng

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

Chuang-Ming Zheng, Longyi Piao, Zhenggen Piao, Chun-Hua Zheng et autres

cn (code pays fourni par la source)

Comparative analysis of urinary, bladder tissue, and stool microbiota in bladder cancer using shotgun metagenomics

Kyungchan Min, Chuang-Ming Zheng, Yanghyun Joo, Sujeong Kim et autres

Urine has been investigated as a less invasive biomarker source for bladder cancer (BCa) because of its direct contact with the bladder mucosa. Urine is assumed to reflect tissue microbiota, but most prior studies relied on 16S rRNA gene sequencing and contamination-prone …

kr (code pays fourni par la source)

Parthenolide enhances imatinib activity in gastrointestinal stromal tumor models through stress-associated apoptosis

Longyi Piao, Zheng-Gen Piao, Chun-Hua Zheng, Dongyuan Xu et autres

cn (code pays fourni par la source)

Optimizing extraction of microbial DNA from urine: Advancing urinary microbiome research in bladder cancer

Chuang-Ming Zheng, Ho Won Kang, Seongmin Moon, Young Joon Byun et autres

PURPOSE: This study aimed to evaluate and optimize microbial DNA extraction methods from urine, a non-invasive sample source, to enhance DNA quality, purity, and reliability for urinary microbiome research and biomarker discovery in bladder cancer. MATERIALS AND METHODS: A total of 302 …

cn, kr (code pays fourni par la source)

Differential Urinary Microbiome and Its Metabolic Footprint in Bladder Cancer Patients Following BCG Treatment

Kyungchan Min, Chuang-Ming Zheng, Sujeong Kim, Hyun Kim et autres

Recent studies have identified a urinary microbiome, dispelling the myth of urine sterility. Intravesical bacillus Calmette–Guérin (BCG) therapy is the preferred treatment for intermediate to high-risk non-muscle-invasive bladder cancer (BCa), although resistance occurs in 30–50% of cases. Progression to muscle-invasive cancer necessitates …

kr (code pays fourni par la source)

Abstract 1278: Differential urinary microbiome and its metabolic footprint in bladder cancer patients following BCG treatment

Xuan‐Mei Piao, Kyungchan Min, Young Joon Byun, Chuang-Ming Zheng et autres

Abstract Introduction & Objectives: Recent insights reveal a urinary microbiome, challenging prior beliefs about urine's sterility. Using 16S rRNA gene sequencing, a pivotal tool in mapping this microbiome, our study delves into the interplay between bladder cancer (BCa), BCG therapy, and the …

kr (code pays fourni par la source)

Abstract 7648: COL6A1 expression as a potential prognostic biomarker for risk stratification of T1HG bladder cancer: Unveiling the aggressive nature of a distinct non-muscle invasive subtype

Xuan‐Mei Piao, Young Joon Byun, Chuang-Ming Zheng, Seon‐Kyu Kim et autres

Abstract Introduction and Objectives: T1 high grade (T1HG) bladder cancer (BC) is a type of non-muscle invasive BC (NMIBC) that is recognized as an aggressive subtype with a heightened propensity for progression. Current risk stratification methods for NMIBC rely on clinicopathological indicators; …

kr (code pays fourni par la source)

Abstract 2809: Bifidobacterium species BB_003 identified through metatranscriptomic analysis with experimentally validated antitumor actions

Xuan‐Mei Piao, Kyungchan Min, Young Joon Byun, Chuang-Ming Zheng et autres

Abstract Introduction & Objectives: A host's microbiome influences both gene expression and phenotype. Whole transcriptome sequencing (WTS) provides information about the microbiome in addition to gene expression. This research probes the correlation between microbial abundance, host gene transcription, and therapeutic efficacy, pinpointing …

kr (code pays fourni par la source)

A 23-Gene Prognostic Index Predicts Progression and Bacillus Calmette-Guérin Response in Non–muscle-invasive Bladder Cancer

Seon‐Kyu Kim, Young Joon Byun, Seonghwan Park, Xuan‐Mei Piao et autres

kr (code pays fourni par la source)

COL6A1 expression as a potential prognostic biomarker for risk stratification of T1 high grade bladder cancer: Unveiling the aggressive nature of a distinct non-muscle invasive subtype

K. B. Kim, Young Joon Byun, Chuang-Ming Zheng, Sungmin Moon et autres

Purpose: T1 high grade (T1HG) bladder cancer (BC) is a type of non-muscle invasive BC (NMIBC) that is recognized as an aggressive subtype with a heightened propensity for progression.Current risk stratification methods for NMIBC rely on clinicopathological indicators; however, these approaches do …

kr (code pays fourni par la source)

COL6A1 expression as a potential prognostic biomarker for risk stratification of T1HG bladder cancer: Unveiling the aggressive nature of a distinct non-muscle invasive subtype

Kyeong Min Kim, Young Joon Byun, Chuang-Ming Zheng, Sungmin Moon et autres

kr (code pays fourni par la source)

A New Treatment Landscape for RCC: Association of the Human Microbiome with Improved Outcomes in RCC

Xuan‐Mei Piao, Young Joon Byun, Chuang-Ming Zheng, Sun Jin Song et autres

Microbes play different roles in metabolism, local or systemic inflammation, and immunity, and the human microbiome in tumor microenvironment (TME) is important for modulating the response to immunotherapy in cancer patients. Renal cell carcinoma (RCC) is an immunogenic tumor, and immunotherapy is …

kr (code pays fourni par la source)