Ka Hee Tak

Polynucleotides Attenuate Atopic Dermatitis-like Inflammatory Signaling in Keratinocytes and Macrophages

Ye Jin Ha, Ka Hee Tak, Jong Lyul Lee, Chan Wook Kim et autres

Background: Atopic dermatitis (AD) is a persistent and recurring skin disease characterized by epidermal barrier dysfunction, immune dysregulation, and elevated expression of proinflammatory mediators. We investigated the anti-inflammatory potential of polynucleotides (PN), highly purified DNA biopolymers isolated from salmonid gonads, in keratinocyte …

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Whole genome sequencing data of early- and late-onset colorectal cancer in 99 Korean patients

Jae-Yoon Kim, Ye Jin Ha, Seung-Jin Park, Sun-Woo Lee et autres

Colorectal cancer (CRC) is the third most prevalent cancer type worldwide. Despite improvements in screening programs, the incidence of early-onset CRC (EOCRC) in patients under 50 years old is rapidly increasing, including in Korea, in contrast to the decreasing trend of late-onset …

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Prognostic and therapeutic value of a 23-gene risk score tailored to the molecular characteristics of mucinous colorectal cancer

Jae‐Yoon Kim, Ye Jin Ha, Ka Hee Tak, Jeong‐Hwan Kim et autres

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Polynucleotides Enhance Skin Barrier Function and Reduce Inflammation in a 2,4‐Dinitrochlorobenzene‐Induced Mouse Model of Atopic Dermatitis

Ye Jin Ha, Ka Hee Tak, Jong Lyul Lee, Chan Wook Kim et autres

BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory dermatological disorder characterized by skin barrier dysfunction, dry skin, pruritus, and aberrant immune responses to external stimuli. Although polynucleotides (PNs) have anti-inflammatory properties, their effect on AD remains unexplored. MATERIALS AND METHODS: This study …

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Molecular characterization of Pseudomyxoma peritonei with single-cell and bulk RNA sequencing

Ye Jin Ha, Seong‐Hwan Park, Seon‐Kyu Kim, Ka Hee Tak et autres

Pseudomyxoma peritonei (PMP), a rare condition characterized by mucinous ascites in the peritoneal cavity, often leads to a poor prognosis. However, omics profiling of this disease remains significantly underexplored. Here, we present single-cell transcriptomic profiling of five PMP cases to identify cell …

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The Effect of Polynucleotide‐Hyaluronic Acid Hydrogel in the Recovery After Mechanical Skin Barrier Disruption

Ye Jin Ha, Ka Hee Tak, Jin‐Min Jung, Jong Lyul Lee et autres

BACKGROUND: The epidermal barrier acts as a defense against external agents as well as helps to maintain body homeostasis. Polynucleotides (PN), exogenous DNA fragments, promote wound repair through their stimulatory and anti-inflammatory effects. Recent findings indicate a synergistic effect of PN and …

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CILP2 is a potential biomarker for the prediction and therapeutic target of peritoneal metastases in colorectal cancer

Ye Jin Ha, Seong‐Hwan Park, Ka Hee Tak, Jong Lyul Lee et autres

Peritoneal metastases (PM) in colorectal cancer (CRC) is associated with a dismal prognosis. Identifying and exploiting new biomarkers, signatures, and molecular targets for personalised interventions in the treatment of PM in CRC is imperative. We conducted transcriptomic profiling using RNA-seq data generated …

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Abstract 6165: Identification of biomarkers of early onset colorectal cancer from transciptome and whole genome data

Yejin Ha, Yun-Jae Shin, Ka Hee Tak, Jong‐Lyul Park et autres

Abstract Colorectal cancer (CRC) is not only the third most commonly occurred cancer worldwide, but it is the leading cause of cancer deaths in 2018. However, the overall incidence of CRC and death from CRC has declined since 1998, the case of …

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Reduced expression of alanyl aminopeptidase is a robust biomarker of non‐familial adenomatous polyposis and non‐hereditary nonpolyposis colorectal cancer syndrome early‐onset colorectal cancer

Ye Jin Ha, Yun Jae Shin, Ka Hee Tak, Jong‐Lyul Park et autres

Abstract Background Early‐onset colorectal cancer (EOCRC) has been increasing in incidence worldwide but its genomic pathogenesis is mostly undetermined. This study aimed to identify robust EOCRC‐specific gene expression patterns in non‐familial adenomatous polyposis (FAP) and non‐hereditary nonpolyposis colorectal cancer syndrome (HNPCC) EOCRC. …

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Clinically Applicable Serum Biomarkers Among 14 Candidates Associated With Recurrence of Stage II and III Colorectal Cancer

Chan Wook Kim, Ye Jin Ha, Ka Hee Tak, Seon Ae Roh et autres

BACKGROUND/AIM: We evaluated the predictive value of candidate serum biomarkers for recurrence in stage II and III colorectal cancer (CRC) after curative surgery. PATIENTS AND METHODS: A total of 33 and 120 patients with CRC with or without recurrence at 5 years …

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Tumor immune microenvironment of primary colorectal adenocarcinomas metastasizing to the liver or lungs

Jin Cheon Kim, Ye Jin Ha, In J. Park, Chan Wook Kim et autres

BACKGROUND: Because of the heterogeneity of metastatic colorectal cancer (mCRC), a genome-wide analysis was performed to characterize the tumor immune microenvironment (TIME). METHODS: RNA-seq analysis of 62 primary CRCs without and 63 with systemic metastasis (SM- and SM+ groups) was conducted, and …

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Analysis of genomic pathogenesis according to the revised Bethesda guidelines and additional criteria

Jin Cheon Kim, Jong-Hwan Kim, Jong Hwan Kim, Chan Wook Kim et autres

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