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Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA containing tumors up-regulate DNA damage and repair, cell cycle control, and mitotic processes, but down-regulate global immune regulation pathways, suggesting new avenues for therapeutic intervention.
us, kr (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
us, kr, gb (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Abstract Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven …
us, kr, gb (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
us, kr, gb (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
kr, us (code pays fourni par la source)
Miin S. Lin, Madhushri Shrikant Varunjikar, Kai Kristoffer Lie, Liv Søfteland et autres
New approach methodologies (NAM), including omics and in vitro approaches, are contributing to the implementation of 3R (reduction, refinement and replacement) strategies in regulatory science and risk assessment. In this study, we present an integrative transcriptomics and proteomics analysis workflow for the …
us, no, it (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
us, kr, gb (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Abstract Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven …
us, kr, gb (code pays fourni par la source)
Miin S. Lin, Se‐Young Jo, Jens Luebeck, Howard Y. Chang et autres
Extrachromosomal DNA is a common cause of oncogene amplification in cancer. The non-chromosomal inheritance of ecDNA enables tumors to rapidly evolve, contributing to treatment resistance and poor outcome for patients. The transcriptional context in which ecDNAs arise and progress, including chromosomally-driven transcription, …
us, kr (code pays fourni par la source)
Doruk Beyter, Miin S. Lin, Yanbao Yu, Rembert Pieper et autres
us (code pays fourni par la source)
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