Liv Søfteland

Toxicometabolomic profiling of perfluorinated sulfonic acids and perfluorinated carboxylic acids reveals conserved effects on lipids and bile acids in Atlantic salmon hepatocytes

Pål A. Olsvik, Marc H.G. Berntssen, Robin Ørnsrud, Liv Søfteland

Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental contaminants that pose potential ecological and health risks to humans and wildlife. This study investigated the comparative toxicity of four PFAS compounds, PFOS, PFOA, PFNA, and PFHxS, using primary hepatocytes isolated from Atlantic …

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Arsenosugar phosphate extracted from seaweed: Isolation, quantification, characterization, and in vitro toxicological studies

Mohammad Ghazali, Veronika Sele, Angeles Sahuquillo, Alba Morales Rodríguez et autres

The increasing interest in seaweed as a potential feed and food source has prompted concerns regarding the presence of potentially toxic arsenic (As) species. Seaweed is known to contain the organic As species arsenosugars, but the toxicity of these compounds is not …

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Arsenosugar phosphate extracted from seaweed: Isolation, Quantification, Characterization and in vitro Toxicological Studies

Mohammad Ghazali, Veronika Sele, Angeles Sahuquillo Estrugo, A. Rodrı́guez et autres

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Multi-tissue proteogenomic analysis for mechanistic toxicology studies in non-model species

Miin S. Lin, Madhushri Shrikant Varunjikar, Kai Kristoffer Lie, Liv Søfteland et autres

New approach methodologies (NAM), including omics and in vitro approaches, are contributing to the implementation of 3R (reduction, refinement and replacement) strategies in regulatory science and risk assessment. In this study, we present an integrative transcriptomics and proteomics analysis workflow for the …

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Arsenic speciation and arsenic feed-to-fish transfer in Atlantic salmon fed marine low trophic feeds based blue mussel and kelp

Marta S. Silva, Jojo Tibon, Sahar Sartipiyarahmadi, Sofie Charlotte Remø et autres

BACKGROUND: Aquaculture aims to reduce the environmental and climate footprints of feed production. Consequently, low trophic marine (LTM) resources such as blue mussels and kelp are potential candidates to be used as ingredients in salmon feed. It is relevant to study potential …

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The impact of varying EPA:DHA ratio on Atlantic salmon health and welfare

Ester Santigosa, Rolf Erik Olsen, Angelico Madaro, Liv Søfteland et autres

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Arsenic Speciation and Arsenic Feed-to-Fish Transfer in Atlantic Salmon Fed Marine Low Trophic Feeds Based Blue Mussel and Kelp

Marta Sousa Silva, Jojo Tibon, Sahar Sartipiyarahmadi, Sofie Charlotte Remø et autres

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Enniatin B and beauvericin affect intestinal cell function and hematological processes in Atlantic salmon (Salmo salar) after acute exposure

Sofie Søderstrøm, Liv Søfteland, Veronika Sele, Anne‐Katrine Lundebye et autres

Unintentional use of mold-infested plant-based feed ingredients are sources of mycotoxins in fish feeds. The presence of the emerging mycotoxins ENNB and BEA in Norwegian commercial fish feeds and plant-based feed ingredients has raised concerns regarding the health effects on farmed Atlantic …

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In vitro toxicity of glyphosate in Atlantic salmon evaluated with a 3D hepatocyte-kidney co-culture model

Liv Søfteland, Pål A. Olsvik

A novel 3D Atlantic salmon co-culture model was developed using primary hepatocytes and kidney epithelial cells isolated from the same fish. Mono and co-cultures of primary hepatocytes and kidney epithelial cells were exposed for 48 h to glyphosate (5, 50 and 500 …

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Beauvericin (BEA) and enniatin B (ENNB)-induced impairment of mitochondria and lysosomes - Potential sources of intracellular reactive iron triggering ferroptosis in Atlantic salmon primary hepatocytes

Sofie Søderstrøm, Kai Kristoffer Lie, Anne‐Katrine Lundebye, Liv Søfteland

Beauvericin (BEA) and enniatin B (ENNB) are emerging mycotoxins frequently detected in plant-based fish feed. With ionophoric properties, they have shown cytotoxic potential in mammalian models. Sensitivity in fish is still largely unknown. Primary hepatocytes isolated from Atlantic salmon (Salmo salar) were …

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Mixture toxicity of chlorpyrifos-methyl, pirimiphos-methyl, and nonylphenol in Atlantic salmon (Salmo salar) hepatocytes

Pål A. Olsvik, Liv Søfteland

Pesticide formulations typically contain adjuvants added to enhance the performance of the active ingredient. Adjuvants may modify the bioavailability and toxicity of pesticides. In this study, the aim was to examine to which degree nonylphenol (NP) may interfere with the toxicity of …

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Chlorpyrifos-induced dysfunction of lipid metabolism is not restored by supplementation of polyunsaturated fatty acids EPA and ARA in Atlantic salmon liver cells

Pål A. Olsvik, S.K. Hammer, Monica Sanden, Liv Søfteland

Exposure to contaminants can lead to accumulation of lipids in the liver. This study aimed to examine whether eicosapentaenoic acid (EPA) and arachidonic acid (ARA) supplementation can protect fish cells against the negative impact of chlorpyrifos (CPF). Atlantic salmon hepatocytes were exposed …

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