John J. Wixted

Response Letter to the Editor Regarding Article: Utility of Sonication for Fracture-Related Infections

Christina Liu, Austin T. Gregg, Stephen C. Moye, Michael Akodu et autres

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Preliminary Data From a Geriatrician‐Led Program for Orthopedic Co‐Managed Hip Fracture Patients Using Zoledronic Acid

Karen Chahal, Jessica Nguyen, Diviya A. Rajesh, Trevor J. McBroom et autres

BACKGROUND: Hip fractures are increasing as the U.S. population ages and result in significant morbidity, mortality, and cost. Despite guidelines recommending osteoporosis treatment after hip fracture, few patients receive treatment. To address this unmet need, our large, tertiary care, academic hospital initiated …

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Is the Timing of Surgery Associated With the Risk of Mortality Among Older Adults Undergoing Operative Hip Fracture Repair?

Michael Akodu, Diviya A. Rajesh, Amy Mitchell-Van Steele, Aung Naing et autres

Introduction Hip fractures are common among older adults; and while urgent fracture fixation is recommended, it is often weighed against preoperative optimization needs. Previous studies have reported conflicting findings on the association between time to surgery and mortality risk. In this study, …

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Utility of Sonication for Fracture-Related Infection

Christina Liu, Austin T. Gregg, Stephen C. Moye, Michael Akodu et autres

OBJECTIVES: To determine the utility of sonication compared to traditional tissue culture in the setting of fracture-related infections (FRIs). METHODS: Design: Retrospective cohort. SETTING: One Level 1 Trauma Center. PATIENT SELECTION CRITERIA: Patients with prior fracture fixation that required a reoperation for …

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Cognitive Behavioural Therapy to Optimize Post-Operative Recovery (COPE): a randomized controlled feasibility trial in extremity fracture patients

Kyle Gouveia, Sheila Sprague, Jodi L. Gallant, Sarah MacRae et autres

BACKGROUND: Outcomes following surgery to operatively manage extremity fractures are variable, and up to two-thirds of patients report chronic post-surgical pain. Preliminary evidence suggests that psychotherapy directed at improving coping skills and reducing somatic vigilance may improve outcomes among fracture patients. The …

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Failure of the Femoral Neck System in a Young Patient: A Case Report

Jude Alawa, Christopher R. Leland, Matthew A. Pappas, Elyse J. Berlinberg et autres

Introduction: Femoral neck fractures in young adults are rare but carry a high risk of complications, including non-union and implant failure. The femoral neck system™ (FNS) is a newer fixation device designed to enhance mechanical stability while minimizing surgical morbidity. Limited reports …

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A computational model that integrates unrestricted callus growth, mechanobiology, and angiogenesis can predict bone healing in rodents

Ahmad Hedayatzadeh Razavi, Nazanin Nafisi, Mohammad Sadegh Ghiasi, Ramin Oftadeh et autres

We present a computational model that integrates mechanobiological regulations, angiogenesis simulations and models natural callus development to simulate bone fracture healing in rodents. The model inputs include atomic force microscopy values and micro-computed tomography on the first-day post osteotomy, which, combined with …

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Stimulation of fracture mineralization by salt-inducible kinase inhibitors

Kaveh Momenzadeh, Diana Yeritsyan, Mohammadreza Abbasian, Nadim Kheir et autres

Introduction: Over 6.8 million fractures occur annually in the US, with 10% experiencing delayed- or non-union. Anabolic therapeutics like PTH analogs stimulate fracture repair, and small molecule salt inducible kinase (SIK) inhibitors mimic PTH action. This study tests whether the SIK inhibitor …

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Sociodemographic and Lifestyle Risk Factors Associated with Fragility Hip Fractures: A Systematic Review and Meta-Analysis

Diana Yeritsyan, Kaveh Momenzadeh, Amin Mohamadi, Sharri Junadi Mortensen et autres

Hip fractures inflict heightened morbidity and mortality upon older adults. Although previous studies have explored the impact of individual demographic factors on hip fracture risk, a comprehensive review can help reconcile disparities among these factors. This meta-analysis encompassed 69 studies involving 976,677 …

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Transcutaneous osseointegration for amputees

Andrew Robert Evans, Kevin D. Tetsworth, Stephen Matthew Quinnan, John J. Wixted

Transcutaneous osseointegration for amputees (TOFA) is an evolving technology that has the potential to revolutionize the interface between the amputee and their prosthesis, showing potential at many levels of amputation. While no amputation is without its challenges, TOFA requires a highly specialized …

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Bacteriophage therapy and current delivery strategies for orthopedic infections: A SCOPING review

Jason Young, Sang Won Lee, Mohammad Javad Shariyate, Alexandria Cronin et autres

OBJECTIVES: Interest in phages as adjunctive therapy to treat difficult infections has grown in the last decade. However, phage dosing and delivery for orthopedic infections have not been systematically summarized. METHODS: Following PRISMA-ScR guidelines, we conducted a SCOPING review through September 1st, …

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In-person cognitive behavioural therapy vs. usual care after surgical management of extremity fractures: an unsuccessful feasibility trial

Kyle Gouveia, Sheila Sprague, Jodi L. Gallant, Gina Del Fabbro et autres

BACKGROUND: Extremity fractures are common, and most are managed operatively; however, despite successful reduction, up to half of patients report persistent post-surgical pain. Furthermore, psychological factors such as stress, distress, anxiety, depression, catastrophizing, and fear-avoidance behaviors have been associated with the development …

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