Jason Young

Novel Transpatellar Tendon Retrograde Insertional Technique for Femoral Implant Placement in Rat Models

Mohammad Javad Shariyate, Tenney Bluman, Shubham Laiwala, Kameron Kraus et autres

Objectives Prosthetic joint infection (PJI) is a serious complication affecting arthroplasty patients. The gold-standard treatment for PJI, two-stage revision, can fail in up to 30% of cases in patients undergoing total knee arthroplasty. Current rat models of PJI following total knee arthroplasty …

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Pharmacokinetics and pharmacodynamics of bacteriophage therapy: A scoping review

Andrew T. Nguyen, Nicita Mehta, KaiLan Mackey, Thomas Cummiskey et autres

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The Widening World of Global Psychology

Jason Young

Smart Phages: Leveraging Artificial Intelligence to Tackle Prosthetic Joint Infections

Nicita Mehta, Andrew T. Nguyen, Edward Kenneth Rodriguez, Jason Young

Traditional antibiotic therapy has encountered significant challenges for clinical treatment of infections for multiple reasons, including antimicrobial resistance (AMR) and poor efficacy against biofilms, demanding research into alternative therapeutic agents. Because of their unique antimicrobial mechanisms as well as their target specificity, …

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Cutaneous Limited Langerhans Cell Histiocytosis Complicated by Late-onset Panhypopituitarism

Nehaal Ahmed, Caroline Jane Davidge-Pitts, Emma F. Johnson, Jason Young et autres

Abstract Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder infrequently complicated by delayed-onset pituitary disease. A 41-year-old female presented with papular, acneiform skin lesions. Shave biopsy demonstrated a superficial dermal epithelioid cell proliferation with S100, CD1a, and langerin positivity on immunohistochemistry …

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RIDDLE ME THIS: WHAT ARE THE IMAGING FEATURES DISTINGUISHING CASEOUS CALCIFICATION OF THE MITRAL ANNULUS FROM THROMBUS AND CARDIAC NEOPLASMS?

Niyati Patel, Jason Young, Madeline K. Mahowald

Abstract TP215: Impact of Carotid Stenosis on Cerebral Glucose Metabolism

Sai Krishna Vallamchetla, Manoj Kumar Jain, Jason Young, Md Manjurul Islam Shourav et autres

Background: Carotid stenosis has been associated with stroke and cognitive impairment. It remains unclear if hypometablism, a marker for neurodegeneration, may be in the mechanistic pathway in the association between carotid stenosis and cognitive decline. This study aims to investigate whether patients …

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Diversity and dermatology through the lens of generative artificial intelligence portrayals: a demographic analysis of race and gender representation

Natalie N. Braun, Nari Lee, Mary M. Morcos, Jason Young

Dermatology remains one of the least diverse medical specialties.1 Recent controversies surrounding diversity, equity, and inclusion initiatives highlight the need to address persistent inequalities within the field.2 In this context, artificial intelligence (AI) presents a unique lens to explore perceptions of diversity. …

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Assessment of Bacteriophage Pharmacokinetic Parameters After Intra-Articular Delivery in a Rat Prosthetic Joint Infection Model

Jason Young, Mohammad Javad Shariyate, Prateek Misra, Ara Nazarian et autres

Prosthetic joint infections (PJIs) are a serious complication of orthopedic surgery. Bacteriophage (phage) therapy shows promise as an adjunctive treatment but requires further study, particularly in its pharmacokinetics. Consequently, we performed a pharmacokinetic assessment of phage therapy for PJIs using a Staphylococcus …

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Bacteriophage Dosing and Its Effect on Bacterial Growth Suppression in a Staphylococcus epidermidis Model: An In Vitro Study

Jason Young, Mohammad Javad Shariyate, Ahmad Hedayatzadeh Razavi, Ara Nazarian et autres

Background: Phages are an emerging therapy in the treatment of prosthetic joint infections, though many challenges remain, including an incomplete understanding of optimal phage dosing. Materials and Methods: We performed an in vitro assessment of how phage dosing as measured by multiplicity …

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Demographic Representation of Generative Artificial Intelligence Images of Physicians

Sang‐Won Lee, Mary M. Morcos, Dong Won Lee, Jason Young

This cross-sectional study compares the race and ethnicity and gender of images of physicians generated by artificial intelligence (AI) with US physician demographic characteristics.

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Artificial Intelligence Portrayals in Orthopaedic Surgery

Mary M. Morcos, Jessica L. Duggan, Jason Young, Shaina A. Lipa

BACKGROUND: The increasing accessibility of artificial intelligence (AI) text-to-image generators offers a novel avenue for exploring societal perceptions. The present study assessed AI-generated images to examine the representation of gender and racial diversity among orthopaedic surgeons. METHODS: Five prominent text-to-image generators (DALL·E …

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