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Profil bibliographique

Alejandro Villalta

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

13Publications signalées
79Citations signalées
2Affiliations récentes

Les institutions déclarées

Les domaines associés

Plant Virus Research StudiesBacteriophages and microbial interactionsVirology and Viral DiseasesViral Infections and Immunology ResearchAnimal Virus Infections Studies

Les publications récentes

Accès ouvert 2025 review OpenAlex

The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms

Alejandro Villalta, Sashi R. Weerawarana, Michael L. Nosella, Karolin Luger

Histones are small basic proteins that form the proteinaceous core of the nucleosome, the repeating building block of chromatin in all eukaryotes. Long thought to be exclusive to eukaryotes, histones are now increasingly appreciated for their roles in organizing genomes across all …

us (code pays fourni par la source)

0 citations Annual Review of Biophysics
Accès ouvert 2025 article OpenAlex

Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures

Alejandro Villalta, Hugo Bisio, Chelsea Marie Toner, Chantal Abergel et autres

Unique among viruses, some giant viruses utilize histones to organize their genomes into nucleosomes. Melbournevirus encodes a distinct H2B-H2A histone doublet variant in addition to the canonical H4-H3 and H2B-H2A doublets. This viral histone variant has a truncated H2B portion and its …

us, fr (code pays fourni par la source)

3 citations Nature Communications
Accès ouvert 2025 preprint OpenAlex

Melbournevirus encodes a shorter H2B-H2A doublet histone variant that forms structurally distinct nucleosome structures

Alejandro Villalta, Hugo Bisio, Chelsea Marie Toner, Chantal Abergel et autres

Abstract Unique among viruses, some giant viruses utilize histones to organize their genomes into nucleosomes. Melbournevirus encodes a distinct H2B-H2A histone doublet variant in addition to the canonical H4-H3 and H2B-H2A doublets. This viral histone variant has a truncated H2B portion and …

us, fr (code pays fourni par la source)

2 citations bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2024 article OpenAlex

Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes

Jean-Marie Alempic, Hugo Bisio, Alejandro Villalta, Sébastien Santini et autres

Abstract The mimivirus 1.2 Mb genome was shown to be organized into a nucleocapsid-like genomic fiber encased in the nucleoid compartment inside the icosahedral capsid. The genomic fiber protein shell is composed of a mixture of two GMC-oxidoreductase paralogs, one of them …

fr, Maroc, it (code pays fourni par la source)

15 citations microLife
Accès ouvert 2023 preprint OpenAlex

Functional redundancy revealed by the deletion of the mimivirus GMC-oxidoreductase genes

Jean-Marie Alempic, Hugo Bisio, Alejandro Villalta, Sébastien Santini et autres

Abstract The mimivirus 1.2Mb genome was shown to be organized into a nucleocapsid-like genomic fiber encased in the nucleoid compartment inside the icosahedral capsid (1). The genomic fiber protein shell is composed of a mixture of two GMC-oxidoreductase paralogs, one of them …

fr, Maroc, ru, it (code pays fourni par la source)

1 citation bioRxiv (Cold Spring Harbor Laboratory)
Accès ouvert 2023 article OpenAlex

Evidence for [2Fe-2S]2+ and Linear [3Fe-4S]1+ Clusters in a Unique Family of Glycine/Cysteine-Rich Fe-S Proteins from Megavirinae Giant Viruses

Alejandro Villalta, Audrey Lartigue, Martin Clémancey, Deborah Byrne et autres

We have discovered a protein with an amino acid composition exceptionally rich in glycine and cysteine residues in the giant virus mimivirus. This small 6 kDa protein is among the most abundant proteins in the icosahedral 0.75 μm viral particles; it has …

fr (code pays fourni par la source)

17 citations Journal of the American Chemical Society
Accès ouvert 2022 article OpenAlex

The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

Alejandro Villalta, Alain Schmitt, Leandro F. Estrozi, Emmanuelle R. J. Quemin et autres

family of giant dsDNA viruses. Little is known about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling the ~0.5 µm icosahedral capsids. Cryo-electron microscopy, cryo-electron tomography, and proteomics revealed that it is encased into a ~30-nm diameter helical …

fr, Maroc, de, gb (code pays fourni par la source)

34 citations eLife
Accès ouvert 2022 peer-review OpenAlex

Author response: The giant mimivirus 1.2 Mb genome is elegantly organized into a 30-nm diameter helical protein shield

Alejandro Villalta, Alain Schmitt, Leandro F. Estrozi, Emmanuelle R. J. Quemin et autres

As a Russian doll, mimivirus dsDNA genome is folded in a nucleocapsid-like structure enclosed in the nucleoid compartment, encased in the icosahedral capsid itself decorated by long glycosylated fibrils surprisingly made of the same protein as the genomic fiber.

fr, Maroc, de, gb (code pays fourni par la source)

0 citations
Accès ouvert 2022 preprint OpenAlex

The giant Mimivirus 1.2 Mb genome is elegantly organized into a 30 nm helical protein shield

Alejandro Villalta, Alain Schmitt, Leandro F. Estrozi, Emmanuelle R. J. Quemin et autres

Abstract Mimivirus is the prototype of the Mimiviridae family of giant dsDNA viruses. Little is known about the organization of the 1.2 Mb genome inside the membrane-limited nucleoid filling the ∼0.5 µm icosahedral capsids. Cryo-electron microscopy, cryo-electron tomography and proteomics revealed that …

fr, de, gb (code pays fourni par la source)

7 citations bioRxiv (Cold Spring Harbor Laboratory)

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