Sashi R. Weerawarana

TFAM organizes DNA into compact higher order structures

Sashi R. Weerawarana, Wei Tian, Karolin Luger

Abstract TFAM (Transcription Factor A, Mitochondrial) is an essential human protein that plays two key roles in mitochondrial DNA (mtDNA) homeostasis. TFAM acts as a transcription factor that specifically binds to promoter regions, but it is also solely responsible for organizing mtDNA …

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Circulating Senescence Protein Links Exercise Adaptation to Health Outcomes

Nicholas Houstis, Qiulian Zhou, Y. ‐W. Chen, Sonja Mittag et autres

Adaptation to physiological stress is fundamental to health but varies widely among individuals. In humans, this heterogeneity is evident in markedly different gains in fitness in response to identical exercise training. The molecular determinants of this variable "trainability" remain poorly understood. Here …

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The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms

Alejandro Villalta, Sashi R. Weerawarana, Michael L. Nosella, Karolin Luger

Histones are small basic proteins that form the proteinaceous core of the nucleosome, the repeating building block of chromatin in all eukaryotes. Long thought to be exclusive to eukaryotes, histones are now increasingly appreciated for their roles in organizing genomes across all …

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Characterization of Medusavirus encoded histones reveals nucleosome-like structures and a unique linker histone

Chelsea Marie Toner, Nicole M. Hoitsma, Sashi R. Weerawarana, Karolin Luger

The organization of DNA into nucleosomes is a ubiquitous and ancestral feature that was once thought to be exclusive to the eukaryotic domain of life. Intriguingly, several representatives of the Nucleocytoplasmic Large DNA Viruses (NCLDV) encode histone-like proteins that in Melbournevirus were …

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Cryo electron microscopy of Medusavirus medusae nucleosome-like particle

Chelsea Marie Toner, Nicole M. Hoitsma, Sashi R. Weerawarana, Karolin Luger

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.