Alexander Kim

Systemic Immune Activation by SARS-CoV-2 mRNA Vaccines Sensitizes Tumors to Immune Checkpoint Blockade

Adam Grippin, Sage Copling, Cecilia Marconi, Nian Li et autres

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Maturity-Onset Diabetes of the Young 10 (MODY10): A Comprehensive Review of Genetics, Clinical Features, and Therapeutic Advances

Ali Mazloum, Sofya G. Feoktistova, Anna Gubaeva, Almaqdad Alsalloum et autres

), leading to defective proinsulin processing, endoplasmic reticulum (ER) stress, and β-cell dysfunction. Current management relies on sulfonylureas or insulin therapy, but these fail to address the underlying genetic defect. Recent research has elucidated the molecular mechanisms of MODY10, including ER stress …

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Sustained Effectiveness, Tolerability, and Safety of Long-Term Prophylaxis with Lanadelumab in Hereditary Angioedema: The Prospective, Phase 4, Noninterventional EMPOWER Real-World Study

Jonathan A. Bernstein, Stephen Betschel, Paula J. Busse, Aleena Banerji et autres

INTRODUCTION: Lanadelumab is approved for long-term prophylaxis of hereditary angioedema (HAE) attacks in patients aged ≥ 2 years in the USA and aged ≥ 12 years in Canada. The EMPOWER Study (NCT03845400) evaluated the real-world effectiveness and safety of lanadelumab in male …

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Leveraging Natural Product‐Inspired Antifungals to Investigate the Mechanism of Action of Peniciaculin A

Ingrid K. Wilt, Adrian Demeritte, Alexander Kim, Weiwei Wang et autres

Ubiquinone mimics known as quinone outside inhibitors (QoIs) are one of the most prominent fungicides used to protect crops in the agricultural industry. Due to chemotype similarities with known QoIs, peniciaculin A, a triaryl natural product, was proposed to exhibit similar broad …

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995MO Association of SARS-COV-2 mRNA vaccines with tumor PD-L1 expression and clinical responses to immune checkpoint blockade

Adam Grippin, Sage Copling, Alexander Kim, Erin L. Young et autres

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Novel and Previously Known Mutations of the KCNV2 Gene Cause Various Variants of the Clinical Course of Cone Dystrophy with Supernormal Rod Response in Children

Almaqdad Alsalloum, I.M. Mosin, Kristina К. Shefer, Natalia Mingaleva et autres

Background/Objectives: Cone dystrophy with supernormal rod response (CDSRR) is a rare autosomal recessive retinal disorder characterized by a delayed and markedly decreased photoreceptor response. In this article, we aim to describe the clinical course and associated molecular findings in children with cone …

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Persistently elevated alloisoleucine in a patient without maple syrup urine disease

Jenna Moore, Lisa E. Kratz, Alexander Kim

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Development of early diagnosis of Parkinson’s disease on animal models based on the intranasal administration of α-methyl-p-tyrosine methyl ester in a gel system

Alexander Kim, Ekaterina Pavlova, А. А. Колачева, Vsevolod Bogdanov et autres

The fight against neurodegenerative diseases, including Parkinson's disease (PD), is a global challenge of this century. The effectiveness of current PD therapy is limited, since it is diagnosed many years after the onset, following the death of most nigrostriatal dopaminergic neurons regulating …

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Epithelial cell responses to rhinovirus identify an early-life–onset asthma phenotype in adults

Eugene H. Chang, Nima Pouladi, Stefano Guerra, Jana Jandová et autres

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A Monoiodotyrosine Challenge Test in a Parkinson’s Disease Model

Alexander Kim, Ekaterina Pavlova, Viktor Blokhin, Vsevolod Bogdanov et autres

Early (preclinical) diagnosis of Parkinson's disease (PD) is a major challenge in modern neuroscience. The objective of this study was to experimentally evaluate a diagnostic challenge test with monoiodotyrosine (MIT), an endogenous inhibitor of tyrosine hydroxylase. Striatal dopamine was shown to decrease …

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A Pilot Study of Changes in the Level of Catecholamines and the Activity of α-2-Macroglobulin in the Tear Fluid of Patients with Parkinson’s Disease and Parkinsonian Mice

Vsevolod Bogdanov, Alexander Kim, M. R. Nodel, Т. А. Павленко et autres

Development of differential and early (preclinical) diagnostics of Parkinson’s disease (PD) is among the priorities in neuroscience. We searched for changes in the level of catecholamines and α-2-macroglobulin activity in the tear fluid (TF) in PD patients at an early clinical stage. …

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Intranasal Ketorolac, Diagnosis and Desensitization for Aspirin Exacerbated Respiratory Disease (AERD)

Amie Nguyen, Bruce L. Zuraw, Christina Wu, Alexander Kim et autres

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