Ali Mazloum

Recombinant Alphaherpesvirus Vectors in Veterinary Vaccinology: Platforms, Applications, and Translational Challenges

Ali Mazloum, Sofya G. Feoktistova, Veronika Ledyaeva, Gava Khulkhachiev et autres

Animal infectious diseases impose severe economic burdens on livestock industries, threaten wildlife populations, and compromise food security. Although vaccination remains the cornerstone of disease prevention, conventional vaccine platforms are often constrained by safety, efficacy, or manufacturing scalability. This narrative review provides a …

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Engineering Liver-Specific Promoters: A Comprehensive Review of Design, Mechanisms, and Clinical Applications in Gene Therapy

Valentin Artemyev, Anastasiia Iu. Paremskaia, Amina A. Dzhioeva, Daria Mishina et autres

The liver is a primary metabolic hub and a pivotal target for gene therapy, owing to its capacity for protein secretion, role in metabolic homeostasis and immune tolerance. Liver-directed gene therapies are used to treat numerous inherited metabolic disorders and coagulation factor …

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Toward Fingerprinting Encrypted C2 Traffic in the Data Plane

Ali Mazloum, Elie Kfoury, Ali AlSabeh, Jose Gomez et autres

• Transport Layer Security (TLS) is the dominant protocol that enables users to securely interact with the Internet. • Threat actors are using TLS to bypass traditional cybersecurity defenses like firewalls and intrusion detection systems. • Modern malware attacks are hiding behind …

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An AAV-Based Therapy Approach for Neurological Phenotypes of X-Linked Adrenoleukodystrophy

Ekaterina Gornostal, Almaqdad Alsalloum, Egor Degtyarev, Ekaterina Kuznetsova et autres

X-linked adrenoleukodystrophy (X-ALD) is a monogenic progressive neurodegenerative disorder, being simultaneously a systemic metabolic disease and demonstrating severe neurological manifestations with effects to the brain and spinal cord. The objective of the current review is to provide a detailed approach to adeno-associated …

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Genetic variations of African swine fever virus MGF 505-9R/10R and I73R/I329L intergenic regions: their role in differentiation between recombinant variant and genotype I and II isolates

Roman Chernyshev, Elizaveta O. Morozova, N. G. Zinyakov, Ali Mazloum et autres

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Maturity-Onset Diabetes of the Young 10 (MODY10): A Comprehensive Review of Genetics, Clinical Features, and Therapeutic Advances

Ali Mazloum, Sofya G. Feoktistova, Anna Gubaeva, Almaqdad Alsalloum et autres

), leading to defective proinsulin processing, endoplasmic reticulum (ER) stress, and β-cell dysfunction. Current management relies on sulfonylureas or insulin therapy, but these fail to address the underlying genetic defect. Recent research has elucidated the molecular mechanisms of MODY10, including ER stress …

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Offloading Encrypted C2 Traffic Mitigation to SmartNICs

Ali Mazloum, Elie Kfoury, Samia Choueiri, Ali AlSabeh et autres

As command and control (C2) traffic increasingly adopts the Transport Layer Security (TLS) protocol, traditional detection methods relying on deep packet inspection (DPI) become ineffective. Machine learning (ML) classifiers offer a promising alternative by identifying encrypted C2 traffic without inspecting payloads. At …

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Volumetric DDoS Attack Detection and Mitigation using P4-DPDK

Samia Choueiri, Ali Mazloum, Sergio Elizalde, Elie Kfoury et autres

Distributed Denial of Service (DDoS) attacks continue to be a major threat to network environments, with their scale and complexity increasing over time. Conventional methods, such as firewalls and scrubbing centers, struggle to cope with the high traffic volumes associated with such …

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Domain Name Security Inspection at Line Rate: Tls Sni Extraction in the Data Plane Using P4 and Dpdk

Ali Mazloum, Ali AlSabeh, Elie Kfoury, Jorge Crichigno

A widely adopted approach to monitor HTTPS traffic leverages the Server Name Identification (SNI) extension of TLS. Generally, the hostname is transferred in plain text over the SNI field and Deep Packet Inspection (DPI) is used to parse the TLS header and …

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Enabling Line-Rate TLS SNI Inspection in P4 Programmable Data Planes

Ali AlSabeh, Ali Mazloum, Elie Kfoury, Jorge Crichigno et autres

With the increasing adoption of the HyperText Transfer Protocol Secure (HTTPS), organizations face new challenges in monitoring traffic to defend against attacks and enforce security policies, such as filtering malicious websites. One widely used technique to monitor HTTPS is by scrutinizing the …

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Performance Evaluation of Stateless Firewalling: Host-Based, SmartNIC, and P4 Switch

Sergio Elizalde, Ali Mazloum, Samia Choueiri, Elie Kfoury et autres

In modern data centers, traditional software-based firewalls often struggle to keep up with the growing demands for robust security. One adopted approach to improve the packet processing efficiency is through software acceleration techniques like the Data Plane Development Kit (DPDK), which significantly …

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Improving Flow Fairness in Non-Programmable Networks Using P4-Programmable Data Planes

Jose Antonio Gomez Gaona, Elie Kfoury, Ali Mazloum, Jorge Crichigno

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