Accès ouvert
2026
article
OpenAlex
Ali Mazloum, Sofya G. Feoktistova, Veronika Ledyaeva, Gava Khulkhachiev et autres
Animal infectious diseases impose severe economic burdens on livestock industries, threaten wildlife populations, and compromise food security. Although vaccination remains the cornerstone of disease prevention, conventional vaccine platforms are often constrained by safety, efficacy, or manufacturing scalability. This narrative review provides a …
ru
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Accès ouvert
2025
article
OpenAlex
Valentin Artemyev, Anastasiia Iu. Paremskaia, Amina A. Dzhioeva, Daria Mishina et autres
The liver is a primary metabolic hub and a pivotal target for gene therapy, owing to its capacity for protein secretion, role in metabolic homeostasis and immune tolerance. Liver-directed gene therapies are used to treat numerous inherited metabolic disorders and coagulation factor …
ru
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Accès ouvert
2025
article
OpenAlex
Ali Mazloum, Sofya G. Feoktistova, Anna Gubaeva, Almaqdad Alsalloum et autres
), leading to defective proinsulin processing, endoplasmic reticulum (ER) stress, and β-cell dysfunction. Current management relies on sulfonylureas or insulin therapy, but these fail to address the underlying genetic defect. Recent research has elucidated the molecular mechanisms of MODY10, including ER stress …
ru
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Accès ouvert
2025
article
OpenAlex
Sodbo Sharapov, Anna Timoshchuk, Olga O. Zaytseva, Д. Е. Маслов et autres
More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoid tissues. While associations with N-glycosylation are implicated in the rising number of liver, cardiometabolic, and immune diseases, little …
ru, hr, us, gb, au, de, nl, dk, be, qa, ch
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Accès ouvert
2025
article
OpenAlex
N. A. Bobrova, D. I. Lyubimova, Daria Mishina, С И Валиева et autres
Phenylketonuria (PKU) is a common inherited metabolic disorder characterised by impaired metabolism of the amino acid phenylalanine. The disease results from a mutation in the phenylalanine hydroxylase (PAH) enzyme, which converts phenylalanine (Phe) into tyrosine (Tyr). The absence or inactivity of this …
ru
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Accès ouvert
2024
article
OpenAlex
Valentin Artemyev, Anna Gubaeva, Anastasiia Iu. Paremskaia, Amina A. Dzhioeva et autres
Gene therapy is a promising approach to the treatment of various inherited diseases, but its development is complicated by a number of limitations of the natural promoters used. The currently used strong ubiquitous natural promoters do not allow for the specificity of …
ru
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Accès ouvert
2024
article
OpenAlex
Sofya G. Feoktistova, Egor Degtyarev, D. I. Smirnova, Pavel Volchkov et autres
Influenza A viruses (IAVs), which belong to the Orthomyxoviridae family, are RNA viruses characterized by a segmented genome that allows them to evolve and adapt rapidly. These viruses are mainly transmitted by wild waterfowl. In this study, we investigated the evolutionary processes …
ru
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Accès ouvert
2024
article
OpenAlex
Egor Degtyarev, Sofya G. Feoktistova, Pavel Volchkov
Influenza A viruses (IAVs) circulate among different species and have the potential to cause significant pandemics in humans. This study focuses on reassortment events in the H5N8 subtype of IAV, which poses a serious threat to public health due to its high …
ru
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Accès ouvert
2024
article
OpenAlex
Almaqdad Alsalloum, I.M. Mosin, Kristina К. Shefer, Natalia Mingaleva et autres
Background/Objectives: Cone dystrophy with supernormal rod response (CDSRR) is a rare autosomal recessive retinal disorder characterized by a delayed and markedly decreased photoreceptor response. In this article, we aim to describe the clinical course and associated molecular findings in children with cone …
ru
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Accès ouvert
2024
article
OpenAlex
Almaqdad Alsalloum, Kristina К. Shefer, Pavel Bogdanov, Natalia Mingaleva et autres
Pathogenic variants in the KCNV2 gene can cause a rare retinal dystrophy that can be inherited recessively, known as cone dystrophy with supernormal rod response (CDSRR). CDSRR leads to specific changes in photoreceptors' electroretinogram response, especially in the rods, poor visual acuity, …
ru
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Accès ouvert
2024
preprint
OpenAlex
Sodbo Sharapov, Anna Timoshchuk, Olga O. Zaytseva, Д. Е. Маслов et autres
Abstract More than a half of plasma proteins are N-glycosylated. Most of them are synthesized, glycosylated, and secreted to the bloodstream by liver and lymphoid tissues. While associations with N-glycosylation are implicated in the rising number of liver, cardiometabolic, and immune diseases, …
ru, hr, us, gb, au, de, nl, dk, be, qa, ch
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Denis Maksimov, Daria A. Naumova, Ekaterina A. Astakhova, Valentin Artemyev et autres
INTRODUCTION. The creation of synthetic adeno-associated virus (AAV) vectors during gene therapy development is a labour-intensive and expensive process. The optimal solution to minimise the time and costs associated with gene therapy development lies in the improvement of methods aimed at assessing …
ru
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