Laurens Wachsmuth

Caspase-8 homo-oligomerization induces apoptosis and suppresses necroptosis to regulate tissue homeostasis

Manolis Pasparakis, Neil Stair, Johanna Seiler, Jonathan Mannion et autres

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DNA-protein cross-links promote cGAS-STING–driven premature aging and embryonic lethality

Ines Tomašković, Cristian Prieto‐Garcia, Maria Bošković, Mateo Glumac et autres

DNA-protein cross-links (DPCs) are highly toxic DNA lesions that block replication and transcription, but their impact on organismal physiology is unclear. We identified a role for the metalloprotease SPRTN in preventing DPC-driven immunity and its pathological consequences. Loss of SPRTN activity during …

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MLKL activity requires a splicing-regulated, druggable intramolecular interaction

Uris Ros, Veronica Martinez-Osorio, Pedro Alberto Valiente, Yasmin Abdelwahab et autres

Necroptosis is an inflammatory form of regulated cell death implicated in a range of human pathologies, whose execution depends on the poorly understood pseudokinase mixed lineage kinase domain-like (MLKL). Here, we report that splicing-dependent insertion of a short amino acid sequence in …

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A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses

Masahiro Nagata, Yasmin Carvalho Schäfer, Laurens Wachsmuth, Manolis Pasparakis

Z-DNA-binding protein 1 (ZBP1) is an interferon-inducible sensor of Z-DNA and Z-RNA, which has emerged as a critical regulator of cell death and inflammation. ZBP1 binds Z-DNA and Z-RNA via its Zα domains, and signals by engaging RIPK3 and RIPK1 via its …

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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Lioba Koerner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer et autres

Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation and in particular the role of RIPK1 …

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ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Lioba Körner, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzwer et autres

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ADAR1 averts fatal type I interferon induction by ZBP1

Huipeng Jiao, Laurens Wachsmuth, Simone Wolf, Juliane Lohmann et autres

Abstract Mutations of the ADAR1 gene encoding an RNA deaminase cause severe diseases associated with chronic activation of type I interferon (IFN) responses, including Aicardi–Goutières syndrome and bilateral striatal necrosis 1–3 . The IFN-inducible p150 isoform of ADAR1 contains a Zα domain …

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Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

Annika Hausmann, Boas Felmy, Leo Kunz, Sanne Kroon et autres

Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this balance and how bacterial exposure elicits the process. Pure LPS induces epithelial NF-κB activation in vivo. However, we found …

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FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells

Robin Schwarzer, Huipeng Jiao, Laurens Wachsmuth, Achim Tresch et autres

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Publisher Correction: Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer et autres

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Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation

Huipeng Jiao, Laurens Wachsmuth, Snehlata Kumari, Robin Schwarzer et autres

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CD11b + CD103 - Sentinel DCs Relay a Tunable Antibacterial NFκB Response in Intestinal Epithelial Cells Via TNF

Annika Hausmann, Boas Felmy, Leo Kunz, Giverny Ganz et autres

ch, cz, de (code pays fourni par la source)