Nathaniel J. Hubert

The Microbiome of an Outpatient Sports Medicine Clinic During a Global Pandemic: Effects of Implementation of a Microbiome-Specific Cleaning Program

Greer Russell, Rabia Alegoz, Kelley Hester, Kayla L. Sierzega et autres

Outpatient healthcare facilities represent potential sources of healthcare-associated infections (HAIs). The purpose of this study was to survey high-contact surfaces in an outpatient physical therapy clinic, characterize the microbiome of those surfaces, and investigate the effects of a microbiome-specific cleaning and hygiene …

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Emodin Inhibited Pathological Cardiac Hypertrophy in Response to Angiotensin-Induced Hypertension and Altered the Gut Microbiome

Levi Evans, Tori Price, Nathaniel J. Hubert, Julia Moore et autres

Objective: Evidence suggests that food bioactives affect the epigenome to prevent pathological cardiac hypertrophy. Recently, we showed that emodin, an anthraquinone, attenuated pathological cardiac hypertrophy and histone deacetylase (HDAC) activity. However, we only examined the cardioprotective effects of emodin’s parent compound and …

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The microbiome of an outpatient rehabilitation clinic and predictors of contamination: A pilot study

Gabriella Brigando, Casey Sutton, Olivia Uebelhor, Nicholas Pitsoulakis et autres

BACKGROUND: Understanding sources of microbial contamination in outpatient rehabilitation (REHAB) clinics is important to patients and healthcare providers. PURPOSE: The purpose of this study was to characterize the microbiome of an outpatient REHAB clinic and examine relationships between clinic factors and contamination. …

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High fat diet disrupts diurnal interactions between small intestinal host innate immune factor REG3γ and gut microbiota resulting in metabolic dysfunction

Katya Frazier, Amal Kambal, Elizabeth A. Zale, Joseph F. Pierre et autres

Background Circadian rhythms are ubiquitous in nature, driving many bodily processes and behaviors, including sleep‐wake cycles and feeding patterns over 24 hours. We and others revealed gut microbes and their functional outputs also exhibit diurnal rhythms that are responsive to how much, …

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High-fat diet disrupts REG3γ and gut microbial rhythms promoting metabolic dysfunction

Katya Frazier, Amal Kambal, Elizabeth A. Zale, Joseph F. Pierre et autres

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Selective Regional Alteration of the Gut Microbiota by Diet and Antibiotics

Elesa Poteres, Nathaniel J. Hubert, Sudeep Poludasu, Gabriella Brigando et autres

The small intestinal gut microbiota has recently been implicated in contributing to metabolic disease. We previously demonstrated that diets rich in saturated milk fat have a particularly strong impact on the small bowel microbiota as opposed to more distal gastrointestinal (GI) regions. …

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High fat diet disrupts diurnal interactions between REG3γ and small intestinal gut microbes resulting in metabolic dysfunction

Katya Frazier, Amal Kambal, Elizabeth A. Zale, Joseph F. Pierre et autres

Summary Gut microbial diurnal oscillations are important diet-dependent drivers of host circadian rhythms and metabolism that ensure optimal energy balance. Yet, the interplay between diet, microbes, and host factors that sustain intestinal oscillations is complex and poorly understood. Here, we report the …

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Western Diet Disrupts REG3γ and Gut Microbial Rhythms Promoting Metabolic Dysfunction

Katya Frazier, Amal Kambal, Elizabeth A. Zale, Joseph F. Pierre et autres

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Phenylpropionc acid produced by gut microbiota alleviates acetaminophen-induced hepatotoxicity

Sungjoon Cho, Xiaotong Yang, Kyoung‐Jae Won, Vanessa Leone et autres

ABSTRACT Acetaminophen (APAP) overdose causes hepatic injury and is major contributor to acute liver injury cases. To investigate potential roles of gut microbiota in APAP-induced liver injury, C57BL/6 mice from Jackson (JAX) or Taconic (TAC) were challenged with APAP. TAC mice were …

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Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation

Xiang Zhong, Jiayao Yu, Katya Frazier, Xiaocheng Weng et autres

Transcriptional regulation of circadian rhythms is essential for lipid metabolic homeostasis, disruptions of which can lead to metabolic diseases. Whether N 6 -methyladenosine (m 6 A) mRNA methylation impacts circadian regulation of lipid metabolism is unclear. Here, we show m 6 A …

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Data on changes to mucosal inflammation and the intestinal microbiota following dietary micronutrients in genetically susceptible hosts

Joseph F. Pierre, Reinhard Hinterleitner, Romain Bouziat, Nathaniel J. Hubert et autres

These data support the findings that dietary micronutrients influence the inflammatory responses and intestinal microbial community structure and function in a model of pouchitis-like small bowel inflammation reported in "Dietary Antioxidant Micronutrients Alter Mucosal Inflammatory Risk in a Murine Model of Genetic …

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Tu1829 - Peripartum Exposure to Antibiotics Induces Persistent Gut Dysbiosis, Skews Host Immune System Development and Increases Risk for Inflammatory Bowel Disease in Genetically Susceptible offspring

Jun Miyoshi, Vanessa Leone, Karen Yang, Sawako Miyoshi et autres