Jun Miyoshi

Successful Endoscopic Removal of a Clip‐stone Complex Following Laparoscopic Cholecystectomy: A Case Report

Takahiro Yamada, Masao Toki, Takuya Ishida, H. Shibuta et autres

An 84-year-old woman with a history of laparoscopic cholecystectomy for gallbladder stone disease 6 years earlier presented to our outpatient clinic. She was referred to gastroenterology for a thorough examination after blood tests showed liver dysfunction. An abdominal non-contrast computed tomography scan …

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Evaluation of Visibility With an Eye‐tracking System: Effectiveness of Narrow‐Band Imaging for Detecting Colorectal Adenoma and Serrated Lesions

M. Mochizuki, Akiko Ohno, Shiori Tsubata, Ryutaro Sumi et autres

ABSTRACT Objectives Image‐enhanced endoscopy may reduce colorectal cancer mortality by improving lesion detection. Narrow‐band imaging and texture and color enhancement imaging are widely used, but their diagnostic efficacy compared with white light imaging remains unclear. This study evaluated narrow‐band imaging and texture …

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Clinical Significance of Endoscopic Improvement at 6 Months in Patients With Ulcerative Colitis Treated With Ustekinumab: A Retrospective Real‐world Analysis

Hiromu Morikubo, Minoru Matsuura, Haruka Komatsu, Takeshi Fujima et autres

ABSTRACT Objectives Ustekinumab (UST), an anti‐interleukin‐12/23 p40 monoclonal antibody, has emerged as an effective therapeutic option for patients with moderate to severe ulcerative colitis (UC). However, early predictors of long‐term treatment response remain unclear. This study aimed to assess whether 6‐month endoscopic …

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Transabdominal intestinal ultrasound versus transmural histopathological findings in severe ulcerative colitis requiring colectomy.

Hiromu Morikubo, Jun Miyoshi, Akimasa Hayashi, Haruka Komatsu et autres

Background: Transabdominal intestinal ultrasound (IUS) is a promising, non-invasive tool for monitoring ulcerative colitis (UC). This modality has the advantage of assessing intestinal inflammation transmurally, suggesting that UC can be considered a transmural disease. Determining what transabdominal IUS findings indicate in terms …

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A case of pseudoxanthoma elasticum treated with endoscopic clip hemostasis for upper gastrointestinal bleeding from a Dieulafoy lesion

Ryosuke Kaji, Akiko Ohno, Jun Miyoshi, Ryutaro Sumi et autres

A 30-year-old woman with upper gastrointestinal bleeding from a Dieulafoy lesion was treated using endoscopic hemostasis. A subsequent interview revealed that she had pseudoxanthoma elasticum (PXE) with an ABCC6 gene mutation, but she had not been under medical care for many years. …

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Gastric Dieulafoy Lesion Bleeding Associated with Hemodynamic Alterations in Median Arcuate Ligament Syndrome: A Case Report

Mitsunori Kusuhara, Akiko Ohno, Jun Miyoshi, Shiori Tsubata et autres

Median arcuate ligament syndrome (MALS) involves compression of the celiac artery and it can cause a hemodynamic disturbance. We report a case of acute upper gastrointestinal bleeding from a Dieulafoy lesion arising from the collateral arterial circulation, considered secondary to MALS. Although …

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Serological Remission Defined by Anti-Integrin αvβ6 Antibody Predicts Long-Term Clinical Remission of Ulcerative Colitis

Noriaki Oguri, Jun Miyoshi, Nobuki Nemoto, Haruka Kamatsu et autres

Background and Aims: Although management of ulcerative colitis (UC) has advanced with the treat-to-target strategy, biomarkers for relapse remain limited. The anti-integrin αvβ6 (V6) antibody reflects epithelial injury and could be a serological biomarker in UC. This retrospective cohort study evaluated whether …

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[The role of imaging in stratified management of ulcerative colitis:a focus on intestinal ultrasound].

Jun Miyoshi, Hiromu Morikubo, Tadakazu Hisamatsu

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Escalation to biologics after corticosteroids in patients with newly diagnosed Crohn’s disease in Japan: a claims analysis from 2010 to 2021

Minoru Matsuura, Annabelle Yoon, Jun Miyoshi, Tadakazu Hisamatsu

BACKGROUND/AIMS: A previous health insurance claims study of Japanese patients with newly diagnosed Crohn's disease (CD) reported an increase in "step-up" approach from 2010 to 2020, with biologic use in the first year remaining stable. This study examined systemic corticosteroid (SCS) use …

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Mayo Endoscopic Subscore at Week 24 Is a Predictor of Future Loss of Response to Vedolizumab in Patients with Ulcerative Colitis in Clinical Remission

Daisuke Saito, Minoru Matsuura, Hiromu Morikubo, Noritaka Hibi et autres

Introduction: Vedolizumab (VDZ) is a gut-selective integrin antagonist approved for the treatment of ulcerative colitis. While its efficacy and safety have been demonstrated in clinical trials, real-world data on long-term treatment persistence and factors associated with loss of response are limited. Methods: …

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Image-enhanced endoscopy improves visibility of endoscopic images in individuals with color vision deficiency

Akiko Ohno, Jun Miyoshi, Mitsunori Kusuhara, Yoko Jinbo et autres

Abstract Color vision deficiency (CVD) may affect perception of color information in gastrointestinal endoscopy. However, the color-universal concept in endoscopy remains underappreciated. We hypothesized that image-enhanced endoscopy (IEE) could improve object/lesion visibility regardless of CVD and tested this hypothesis with volunteers of …

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Mechanism of IL-10 production via IL-1R in gut macrophages

Noritaka Hibi, Satoshi Kuronuma, Osamu Takeuchi, Maria Carla Tablante et autres

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