Remy Vu

The AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes epidermal and immune homeostasis in atopic dermatitis-like skin inflammation

Zeyu Chen, Morgan Dragan, Peng Sun, Daniel Haensel et autres

The skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors and regulates barrier robustness and immune homeostasis. AhR agonists have been approved by the FDA for psoriasis treatment and are in …

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An AhR-Ovol1-Id1 regulatory axis in keratinocytes promotes skin homeostasis against atopic dermatitis

Zeyu Chen, Morgan Dragan, Peng Sun, Daniel Haensel et autres

ABSTRACT Skin is our outer permeability and immune defense barrier against myriad external assaults. Aryl hydrocarbon receptor (AhR) senses environmental factors and regulates barrier robustness and immune homeostasis. AhR agonist is in clinical trial for atopic dermatitis (AD) treatment, but the underlying …

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Ovol1/2 loss‐induced epidermal defects elicit skin immune activation and alter global metabolism

Morgan Dragan, Zeyu Chen, Yumei Li, Johnny Le et autres

Skin epidermis constitutes the outer permeability barrier that protects the body from dehydration, heat loss, and myriad external assaults. Mechanisms that maintain barrier integrity in constantly challenged adult skin and how epidermal dysregulation shapes the local immune microenvironment and whole-body metabolism remain …

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Epithelial–Mesenchymal Plasticity and Endothelial–Mesenchymal Transition in Cutaneous Wound Healing

Remy Vu, Morgan Dragan, Peng Sun, Sabine Werner et autres

Epithelial and endothelial cells possess the inherent plasticity to undergo morphological, cellular, and molecular changes leading to their resemblance of mesenchymal cells. A prevailing notion has been that cutaneous wound reepithelialization involves partial epithelial-to-mesenchymal transition (EMT) of wound-edge epidermal cells to enable …

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Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

Remy Vu, Suoqin Jin, Peng Sun, Daniel Haensel et autres

Delayed and often impaired wound healing in the elderly presents major medical and socioeconomic challenges. A comprehensive understanding of the cellular/molecular changes that shape complex cell-cell communications in aged skin wounds is lacking. Here, we use single-cell RNA sequencing to define the …

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757 Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

Remy Vu, Shuo Jin, P. Sun, Q. Nie et autres

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Epidermis-Intrinsic Transcription Factor Ovol1 Coordinately Regulates Barrier Maintenance and Neutrophil Accumulation in Psoriasis-Like Inflammation

Morgan Dragan, Peng Sun, Zeyu Chen, Xianghui Ma et autres

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OVOL1 Regulates Psoriasis-Like Skin Inflammation and Epidermal Hyperplasia

Peng Sun, Remy Vu, Morgan Dragan, Daniel Haensel et autres

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223 Skin barrier, inflammation, and metabolism– connections through Ovol1/Ovol2

Mariola Dragan, Ping‐Hui Sun, Daniel Haensel, Remy Vu et autres

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Defining Epidermal Basal Cell States during Skin Homeostasis and Wound Healing Using Single-Cell Transcriptomics

Daniel Haensel, Suoqin Jin, Peng Sun, Rachel Cinco et autres

state to early-response state, proliferate at the juncture of these two states, or become growth arrested before differentiating into spinous cells. Wound healing induces plasticity manifested by dynamic basal-spinous interconversions at multiple basal transcriptional states. Our study provides a systematic view of …

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