Sabine Werner

An FGF7-FGFR2-KLF4 feedback loop sustains anti-inflammatory signaling in epithelial cells

Luca Ferrarese, Daria Wüst, Liliana Bento Lopes, Ismail Küçükaylak et autres

ABSTRACT Chronic or excessive inflammation are hallmarks of many human diseases, but the endogenous factors that limit inflammatory responses are insufficiently characterized. We discovered a broad anti-inflammatory function of fibroblast growth factor 7 (FGF7), which is mediated via epithelial cels. FGF7 suppressed …

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A multiomics analysis identifies retinol metabolism in fibroblasts as a key pathway in wound healing

Till Wüstemann, Elizabeta Madzharova, Mateusz S. Wietecha, Norbert B. Ghyselinck et autres

Impaired wound healing poses a major and increasingly frequent health problem. Among the key players in the healing process are fibroblasts, but their metabolic profile in healing wounds is largely unknown. Using a combination of transcriptomics, targeted proteomics, and metabolomics, we identified …

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MIRO2-mediated mitochondrial transfer from cancer cells induces cancer-associated fibroblast differentiation

Michael Cangkrama, Huan Liu, Xiaoyu Wu, Josephine Yates et autres

Cancer-associated fibroblasts (CAFs) are key components of the tumor microenvironment that commonly support cancer development and progression. Here we show that different cancer cells transfer mitochondria to fibroblasts in cocultures and xenograft tumors, thereby inducing protumorigenic CAF features. Transplantation of functional mitochondria …

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Characterization of murine excisional wounds based on atomic force microscopy indentation

H. Junker, Adam Wahlsten, Raoul Hopf, Mateusz S. Wietecha et autres

Murine excisional skin wounds represent a widely applied model to investigate factors influencing the healing process. Among those, mechanical factors are receiving increasing attention, for instance concerning the role of fibroblasts' activation in contracting the wound and forming a fibrotic scar. Atomic …

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Quantification of Stretch-Induced Stimuli Altering the Mechanome of Dermal Fibroblasts

Anastasiya Martyts, David Sachs, Alberto Stracuzzi, Daniela Kromer et autres

Deformation is a key determinant of skin pathophysiology, as seen in skin growth during pregnancy and tissue expansion and in pathological processes such as excessive scarring in wounds under tension. However, the mechanisms underlying dermal cell response to deformation are poorly understood, …

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Vaccination-based immunotherapy to target profibrotic cells in liver and lung

Michal Sobecki, Jing Chen, Ewelina Krzywińska, Shunmugam Nagarajan et autres

Peroxisomes are critical for a unique metabolic demand and survival of alveolar macrophages

Mai Matsushita, Jonathan Muri, Ivan Berest, Fengqi Li et autres

Tissue-resident macrophages (TRMs) populate throughout various tissues, and their homeostatic metabolism is heavily influenced by these microenvironments. Peroxisomes are organelles that contribute to lipid metabolism. However, the involvement of these organelles in the bioenergetics of TRMs remains undetermined. We conducted a developmental …

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Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation

Michael Koch, Luca Ferrarese, Maya Ben‐Yehuda Greenwald, Sabine Werner

Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by an impaired epidermal barrier and immunological alterations. The activity of the cytoprotective NRF2 transcription factor is reduced in the epidermis of AD patients. To determine the functional relevance of this deficiency, …

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An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver

Andrii Kuklin, C. Slabber, Luigi Tortola, Gerhard Liebisch et autres

Background & Aims The liver has remarkable regenerative and detoxification capacities, which require the Nrf2 and NF-κB transcription factors. Although their individual functions in hepatocytes are well characterized, knowledge about their crosstalk in the adult liver is limited. Methods We performed AAV8-Cre …

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An Nrf2-NF-κB Crosstalk Controls Hepatocyte Proliferation in the Normal and Injured Liver

Andrii Kuklin, C. Slabber, Luigi Tortola, Chan Lap Kwan et autres

Pioneers in Dermatology and Venereology: An interview with Professor Sabine Werner

Sabine Werner

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Skin layer-specific spatiotemporal assessment of micrometabolism during wound angiogenesis

Weiye Li, Yu‐Hang Liu, Fumimasa Kubo, Sabine Werner et autres

Proper oxygen delivery through the microvasculature to injury site is essential to ensure the metabolic cascade during wound healing. Adaptation of vascular structure and oxygenation is key to unravel the regulation of blood perfusion, oxygen distribution and new tissue formation. Yet, visualizing …

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