Accès ouvert
2023
article
OpenAlex
Deidre Beavers, Timothy Brunson, Nasim Sanati, Lisa R. Matthews et autres
Understudied or dark proteins have the potential to shed light on as-yet undiscovered molecular mechanisms that underlie phenotypes and suggest innovative therapeutic approaches for many diseases. The Reactome-IDG (Illuminating the Druggable Genome) project aims to place dark proteins in the context of …
us, ca, gb
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Timothy Brunson, Nasim Sanati, Lisa R. Matthews, Robin Haw et autres
Limited knowledge about a substantial portion of protein coding genes, known as "dark" proteins, hinders our understanding of their functions and potential therapeutic applications. To address this, we leveraged Reactome, the most comprehensive, open source, open-access pathway knowledgebase, to contextualize dark proteins …
us, ca, gb
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Marc E. Gillespie, Bijay Jassal, Ralf Stephan, Marija Orlic-Milacic et autres
The Reactome Knowledgebase (https://reactome.org), an Elixir core resource, provides manually curated molecular details across a broad range of physiological and pathological biological processes in humans, including both hereditary and acquired disease processes. The processes are annotated as an ordered network of molecular …
ca, us, br, gb, at, cn, co
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Johannes Griss, Guilherme Viteri, Konstantinos Sidiropoulos, Vy Nguyen et autres
Pathway analyses are key methods to analyze 'omics experiments. Nevertheless, integrating data from different 'omics technologies and different species still requires considerable bioinformatics knowledge.Here we present the novel ReactomeGSA resource for comparative pathway analyses of multi-omics datasets. ReactomeGSA can be used through …
gb, ru, at
(code pays fourni par la source)
Accès ouvert
2020
preprint
OpenAlex
Johannes Griss, Guilherme Viteri, Konstantinos Sidiropoulos, Vy Nguyen et autres
Abstract Pathway analyses are key methods to analyse ‘omics experiments. Nevertheless, integrating data from different ‘omics technologies and different species still requires considerable bioinformatics knowledge. Here we present the novel ReactomeGSA resource for comparative pathway analyses of multi-omics datasets. ReactomeGSA can be …
gb, at
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Bijay Jassal, Lisa R. Matthews, Guilherme Viteri, Chuqiao Gong et autres
Abstract The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism and other cellular processes as an ordered network of molecular transformations in a single consistent data model, an extended version of a classic metabolic map. Reactome functions …
ca, us, gb
(code pays fourni par la source)
Accès ouvert
2019
article
OpenAlex
Guilherme Viteri, Lisa R. Matthews, Thawfeek Varusai, Marc E. Gillespie et autres
Reactome is a manually curated, open-source, open-data knowledge base of biomolecular pathways. Reactome has always provided clear credit attribution for authors, curators and reviewers through fine-grained annotation of all three roles at the reaction and pathway level. These data are visible in …
gb, us, ca, cn
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
Antonio Fabregat, Florian Korninger, Guilherme Viteri, Konstantinos Sidiropoulos et autres
Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. One of its main priorities is to provide easy and efficient access to its high quality curated data. At present, biological pathway databases typically store their contents in relational …
gb, es, us, ca, cn
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Antonio Fabregat, Konstantinos Sidiropoulos, Guilherme Viteri, Pablo Marín-García et autres
Motivation: Reactome is a free, open-source, open-data, curated and peer-reviewed knowledgebase of biomolecular pathways. For web-based pathway visualization, Reactome uses a custom pathway diagram viewer that has been evolved over the past years. Here, we present comprehensive enhancements in usability and performance …
gb, es, us, ca, cn
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Antonio Fabregat, Lisa R. Matthews, Konstantinos Sidiropoulos, Marc E. Gillespie et autres
The Reactome Knowledgebase (https://reactome.org) provides molecular details of signal transduction, transport, DNA replication, metabolism, and other cellular processes as an ordered network of molecular transformations-an extended version of a classic metabolic map, in a single consistent data model. Reactome functions both as …
gb, us, ca
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Konstantinos Sidiropoulos, Guilherme Viteri, Cristoffer Sevilla, Marissa Webber et autres
MOTIVATION: Reactome is a free, open-source, open-data, curated and peer-reviewed knowledge base of biomolecular pathways. Pathways are arranged in a hierarchical structure that largely corresponds to the GO biological process hierarchy, allowing the user to navigate from high level concepts like immune …
gb, ca, us, cn
(code pays fourni par la source)
Accès ouvert
2017
article
OpenAlex
Antonio Fabregat, Konstantinos Sidiropoulos, Guilherme Viteri, Oscar Forner et autres
BACKGROUND: Reactome aims to provide bioinformatics tools for visualisation, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modelling, systems biology and education. Pathway analysis methods have a broad range of applications in physiological and biomedical research; one of …
gb, es, us, ca, cn
(code pays fourni par la source)