Fabrice Krier

Shifting paradigms: phosphatases from basic biology to druggable targets

Catia L. Pierotti, Marian Brenner, Yamini Chand, Fabrice Krier et autres

The EMBO Workshop 'Phosphatases: from basic research to translation' (27 to 31 July 2025, Würzburg, Germany) brought together researchers from academia and industry for a deep dive into the rapidly evolving world of phosphatase biology. Over five days, participants explored the interplay …

de, ua, rs (code pays fourni par la source)

Identification of phosphatases that dephosphorylate the co-chaperone BAG3

Thomas Kokot, Johannes P. Zimmermann, Yamini Chand, Fabrice Krier et autres

The co-chaperone BAG3 plays critical roles in maintaining cellular proteostasis. It associates with 14-3-3 proteins during the trafficking of aggregation-prone proteins and facilitates their degradation through chaperone-assisted selective autophagy in cooperation with small heat shock proteins. Although reversible phosphorylation regulates BAG3 function, …

de (code pays fourni par la source)

iNClusive: a database collecting useful information on non-canonical amino acids and their incorporation into proteins for easier genetic code expansion implementation

Leon-Samuel Icking, Andreas Martin Riedlberger, Fabian Krause, Jonas Widder et autres

The incorporation of non-canonical amino acids (ncAAs) into proteins is a powerful technique used in various research fields. Genetic code expansion (GCE) is the most common way to achieve this: a specific codon is selected to be decoded by a dedicated tRNA …

de (code pays fourni par la source)

Development of an original thermoforming apparatus to be coupled to hot melt extrusion for the continuous production of itraconazole-based amorphous solid dispersions

Justine Thiry, Alain Nuozzi, Carl Emmerechts, E. Beeckman et autres

be (code pays fourni par la source)

Bioavailability enhancement of itraconazole-based solid dispersions produced by hot melt extrusion in the framework of the Three Rs rule

Justine Thiry, Miranda Kok, Laurence Collard, Antoine Frère et autres

be (code pays fourni par la source)

Continuous production of itraconazole-based solid dispersions by hot melt extrusion: Preformulation, optimization and design space determination

Justine Thiry, Pierre Lebrun, Chloe Vinassa, Marine Adam et autres

be (code pays fourni par la source)

Hot-melt extrusion as a continuous manufacturing process to form ternary cyclodextrin inclusion complexes

Justine Thiry, Fabrice Krier, Shenelka Ratwatte, Jean‐Michel Thomassin et autres

be (code pays fourni par la source)

Selection of a discriminant and biorelevant in vitro dissolution test for the development of fenofibrate self-emulsifying lipid-based formulations

Aude Pestieau, Fabrice Krier, Adeline Brouwers, Bruno Streel et autres

be (code pays fourni par la source)

Hot Melt Extrusion as a New Method to Form Inclusion Complexes with Cyclodextrins

Justine Thiry, Fabrice Krier, Shenelka Ratwatte, Jean‐Michel Thomassin et autres

be (code pays fourni par la source)

A simple calibration approach based on film-casting for confocal Raman microscopy to support the development of a hot-melt extrusion process

Lauranne Netchacovitch, Justine Thiry, Charlotte De Bleye, Elodie Dumont et autres

be (code pays fourni par la source)

Investigation of a suitable in vitro dissolution test for itraconazole-based solid dispersions

Justine Thiry, G. Broze, Aude Pestieau, Andrew S. Tatton et autres

be (code pays fourni par la source)

Modeling, sensitivity analysis and parameter identification of a twin screw extruder

Jonathan Grimard, Laurent Dewasme, Justine Thiry, Fabrice Krier et autres

Following the recent success of hot-melt extrusion in the pharmaceutical field, monitoring and control are increasingly applied. In this study, a mathematical model consisting of mass and energy balance partial differential equations is developed and parameters related to material transportation are inferred …

be (code pays fourni par la source)