Accès ouvert
2026
article
OpenAlex
Catia L. Pierotti, Marian Brenner, Yamini Chand, Fabrice Krier et autres
The EMBO Workshop 'Phosphatases: from basic research to translation' (27 to 31 July 2025, Würzburg, Germany) brought together researchers from academia and industry for a deep dive into the rapidly evolving world of phosphatase biology. Over five days, participants explored the interplay …
de, ua
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Accès ouvert
2026
article
OpenAlex
Catia L. Pierotti, Maja Köhn
Src homology 2 (SH2) domain-containing phosphatase-2 (SHP2, PTPN11) is implicated in diseases such as cancer and RASopathies, where it is often mutated. It has gained strong attention due to promising new drug development strategies, with drug candidates currently in clinical trials. SHP2 …
de, ua
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Accès ouvert
2025
article
OpenAlex
Azin Kiani, Catia L. Pierotti, Franziska Schedel, Thomas Kokot et autres
Src homology 2 (SH2) domain‐containing phosphatase 2 (SHP2) mediates important signal transduction upon cell surface receptor stimulation, regulating multiple cellular functions. In addition to the catalytically active phosphotyrosine (pTyr) phosphatase domain, SHP2 contains two regulatory pTyr‐binding domains: the N‐SH2 and C‐SH2 domains. …
de
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Accès ouvert
2023
article
OpenAlex
Catia L. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey et autres
Necroptosis is a mode of programmed, lytic cell death that is executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following activation by the upstream kinases, receptor-interacting serine/threonine protein kinase (RIPK)-1 and RIPK3. Dysregulated necroptosis has been implicated in the pathophysiology of …
au
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Accès ouvert
2022
article
OpenAlex
Annette V. Jacobsen, Catia L. Pierotti, Kym N. Lowes, Amanda E. Au et autres
Necroptosis is a form of caspase-independent programmed cell death that arises from disruption of cell membranes by the mixed lineage kinase domain-like (MLKL) pseudokinase after its activation by the upstream kinases, receptor interacting protein kinase (RIPK)-1 and RIPK3, within a complex known …
au
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2022
article
OpenAlex
Catia L. Pierotti, John Silke
Recent studies, reviewed here, using a cigarette smoke exposure model for chronic obstructive pulmonary disease (COPD) in Ripk3 and Mlkl knock-out mice, and correlation with patient samples, suggest necroptosis plays a pathophysiological role in COPD by promoting inflammation, airway remodeling and emphysema.
au
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2020
article
OpenAlex
Catia L. Pierotti, Maria C. Tanzer, Annette V. Jacobsen, Joanne M. Hildebrand et autres
Necroptosis is an inflammatory form of programmed cell death that has been implicated in various human diseases. Compound 2 is a more potent analogue of the published compound 1 and inhibits necroptosis in human and murine cells at nanomolar concentrations. Several target …
au
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Accès ouvert
2014
article
OpenAlex
Joanne M. Hildebrand, Maria C. Tanzer, Isabelle S. Lucet, Samuel N. Young et autres
Necroptosis is considered to be complementary to the classical caspase-dependent programmed cell death pathway, apoptosis. The pseudokinase Mixed Lineage Kinase Domain-Like (MLKL) is an essential effector protein in the necroptotic cell death pathway downstream of the protein kinase Receptor Interacting Protein Kinase-3 …
au, nz
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