Pierre Lebrun

Spatiotemporal dynamics of Phytophthora infestans airborne inoculum in Belgium

Vivien Le Vourch, Alain Decroës, Salomé Thonon, Charlotte Liénard et autres

Abstract For nearly a century, scientists have strived to model the development of Phytophthora infestans (Pi) to predict late blight infections in potatoes. This has led to the use of decision support systems (DSSs) that rely on forecasting models based on environmental …

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Optimization of silver nanoparticles synthesis by chemical reduction to enhance SERS quantitative performances: Early characterization using the quality by design approach

Julie Horne, Charlotte De Bleye, Pierre Lebrun, Kevser Kemik et autres

Surface-enhanced Raman scattering (SERS) is a vibrational widely used technique thanks to its multiple advantages such as its high specificity and sensitivity. The Raman signal exaltation comes from the use of metallic nanoparticles (Nps) acting as antennas by amplifying the Raman scattering. …

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Potato Production in Northwestern Europe (Germany, France, the Netherlands, United Kingdom, Belgium): Characteristics, Issues, Challenges and Opportunities

Jean‐Pierre Goffart, Anton J. Haverkort, R. M. J. Storey, Norbert Ulf Haase et autres

In Northwestern Europe, Germany, France, the Netherlands, the UK and Belgium constitute the biggest five potato producers, with total potato crop production around 60% of EU-28 production before Brexit. Soil and climate conditions are highly favourable for potato growth in this region. …

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Worship in translation. Quand l'individu fait le lieu

Bastien Couturier, Benjamin Chavardès, Julien Correia, Pierre Lebrun

International audience

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Controlling the Reproducibility of AC50 Estimation during Compound Profiling through Bayesian β-Expectation Tolerance Intervals

Wilson Tendong, Pierre Lebrun, Bie M. P. Verbist

During drug discovery, compounds/biologics are screened against biological targets of interest to find drug candidates with the most desirable activity profile. The compounds are tested at multiple concentrations to understand the dose-response relationship, often summarized as AC50 values and used directly in …

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Risk-Based Similarity Testing for Potency Assays Using MCMC Simulations

Perceval Sondag, Pierre Lebrun

In potency assays, the relative potency (RP) is the measure of the biological activity of a test product relative to a reference standard. It is calculated as the horizontal difference between the log(concentration)–response curves of each product. Parallelism (or similarity) between those …

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Bayesian Methods for the Design and Analysis of Stability Studies

Tonakpon Hermane Avohou, Pierre Lebrun, Eric Rozet, Bruno Boulanger

This chapter focuses on the benefits of using the Bayesian framework to manage risks and make decisions, in the place of the commonly used traditional frequentist methods to support the evaluation of stability data. Statistical modelling plays a prominent role in the …

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity

Simone Kosol, Sara Contreras-Martos, Alessandro Piai, Mihály Váradi et autres

Crosstalk between cellular pathways is often mediated through scaffold proteins that function as platforms for the assembly of signaling complexes. Based on yeast two-hybrid analysis, we report here the interaction between two complex scaffold proteins, CREB-binding protein (CBP) and the Ras GTPase-activating-like …

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Risk-Based Similarity Testing for Potency Assays Using MCMC Simulations

Perceval Sondag, Pierre Lebrun

In potency assays, the relative potency (RP) is the measure of the biological activity of a test product relative to a reference standard. It is calculated as the horizontal difference between the log(concentration)–response curves of each product. Parallelism (or similarity) between those …

SFC-MS for the quality control of cannabis: addressing the potential adulteration with synthetic cannabinoids

Hugues Jambo, Amandine Dispas, Tonakpon Hermane Avohou, S. André et autres

Recent years have been the stage to a shift in cannabis policies and trends that have impacted cannabis usage and public perception. On the other hand, there has also been a rise in the development and distribution of synthetic cannabinoids which are …

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SFC-MS as a preventive tool for the quality control of potentially adulterated cannabis with synthetic cannabinoids

Hugues Jambo, Amandine Dispas, Tonakpon Hermane Avohou, S. André et autres

Recent years have been the stage to a shift in cannabis policies and trends that have impacted cannabis usage and public perception. It has also caught the attention of the pharmaceutical industry and cannabis is increasingly evaluated as a medicine in the …

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Quantification of Intrinsically Disordered Proteins: A Problem Not Fully Appreciated

Sara Contreras-Martos, Hung Huy Nguyen, Phuong N. Nguyen, Nevena Hristozova et autres

Protein quantification is essential in a great variety of biochemical assays, yet the inherent systematic errors associated with the concentration determination of intrinsically disordered proteins (IDPs) using classical methods are hardly appreciated. Routinely used assays for protein quantification, such as the Bradford …

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