Guanghui Liu

Integrin-mediated mechanotransduction in the tumor microenvironment: macrophage-centered signaling mechanisms and immune remodeling

Guanghui Liu, Qi Sun, Yuting Zhong, Lu Liu et autres

BACKGROUND: Tumor-associated macrophages (TAMs) play a critical role in the immunosuppressive tumor microenvironment (TME). Although the biochemical signaling pathways regulating TAMs have been extensively elucidated, how these cells persistently sense physical properties of the tumor stroma-such as matrix stiffness, tension, and compression-and …

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Targeting Tumor-Associated Macrophages to Reshape the Immuno-Mechanical Landscape: Molecular Mechanisms and Therapeutic Strategies

Guanghui Liu, Yu Yang, Zichen Guo, Lijuan Liu et autres

The progression and therapeutic resistance of solid tumors are profoundly influenced by the mechanical microenvironment, in which extracellular matrix stiffening, elevated interstitial pressure, and aberrant mechanotransductive signaling constitute critical physical barriers. Tumor-associated macrophages (TAMs) occupy a central position in this process. They …

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GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway

Yuanhua Liu, Guanghui Liu, Jingjing Mei, J M Li et autres

BACKGROUND: M2 macrophage polarization is a key driver of lung adenocarcinoma (LUAD) progression, yet its underlying regulatory mechanisms remain unclear. The expression pattern and biological function of the gap junction protein GJB2 in LUAD have not been elucidated to date. METHODS: TCGA …

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Mechanism of Non–Small Cell Lung Cancer–Derived Extracellular Vesicle miRNA hsa‐let‐7b‐5p Targeting AP1S1 to Regulate M2 Macrophage Polarization

Lijuan Liu, Zixing Kou, Tianhua Wang, Qihang Shang et autres

Background: Non-small cell lung cancer (NSCLC) accounts for over 80% of lung cancer cases. Further, the complex tumor immune microenvironment (TIME) is a critical factor in treatment resistance and poor prognosis associated with tumors. Tumor-associated macrophages (TAMs), a major component of the …

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Synergies Between Case-Based Reasoning and Deep Learning for Survival Analysis in Oncology

Isabelle Bichindaritz, Guanghui Liu

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Adaptive Multi-omics Survival Analysis in Cancer

Isabelle Bichindaritz, Guanghui Liu

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Integrative survival analysis of breast cancer with gene expression and DNA methylation data

Isabelle Bichindaritz, Guanghui Liu, C. L. R. Bartlett

MOTIVATION: Integrative multi-feature fusion analysis on biomedical data has gained much attention recently. In breast cancer, existing studies have demonstrated that combining genomic mRNA data and DNA methylation data can better stratify cancer patients with distinct prognosis than using single signature. However, …

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