Jingjing Mei

Knockdown of CDC20 attenuates pulmonary fibrosis by repressing fibroblast activation via the TSC1-mediated mTOR pathway

Yatao Guo, Mengchan Zhu, Ruyi Li, Jia Li et autres

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Inhba is transcriptionally regulated by Foxa1 through the PI3K/AKT signal pathway in acute lung injury

Ying Liu, Guanghui Liu, Jingjing Mei, Jia Li et autres

Acute lung injury (ALI) is a fulminant respiratory failure syndrome with no targeted therapy. We show that Inhba is sharply upregulated in the damaged lung tissue of mice and in BEAS-2B cells, and its abundance tracks with cytokine storm and reactive oxygen …

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Interleukin 1-Beta Potentially Contributes to Chronic Obstructive Pulmonary Disease Development by Inducing Reactive Oxygen Species Production in Neutrophils

Jingjing Mei, Yuanhua Liu, Yan Kang, R X Li et autres

Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and excessive mucin production. Two major gel-forming mucins, MUC5AC and MUC5B, correlate with worsened disease progression and pulmonary function. In COPD, neutrophils are important players in chronic inflammation that contribute to …

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GJB2 drives LUAD progression in part via cAMP-mediated M2 macrophage polarization through the PKA-CREB pathway

Yuanhua Liu, Guanghui Liu, Jingjing Mei, J M Li et autres

BACKGROUND: M2 macrophage polarization is a key driver of lung adenocarcinoma (LUAD) progression, yet its underlying regulatory mechanisms remain unclear. The expression pattern and biological function of the gap junction protein GJB2 in LUAD have not been elucidated to date. METHODS: TCGA …

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The Impact of Rural Fiscal Budget Management on Rural Economic Revitalization and Its Realization Paths

Wenqi Zheng, Yifei Wang, Shuyao Zhang, Le Zhang et autres

The construction of the new countryside is inseparable from the support of financial funds, and budget performance management is an important part of the modern financial system. Based on this, this paper analyzes the importance of new rural budget performance management in …

Mitoxantrone ameliorates ineffective erythropoiesis in a β-thalassemia intermedia mouse model

Haihang Zhang, Rui Liu, Zheng Fang, Ling Nie et autres

ABSTRACT: β-thalassemia is a condition characterized by reduced or absent synthesis of β-globin resulting from genetic mutations, leading to expanded and ineffective erythropoiesis. Mitoxantrone has been widely used clinically as an antitumor agent considering its ability to inhibit cell proliferation. However, its …

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Histone acetyltransferase CSRP2BP promotes the epithelial–mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin

Xiaohui Yang, Fei Sun, Yueying Gao, Mengyongwei Li et autres

BACKGROUND: Dysregulated epithelial-mesenchymal transition (EMT) is involved in cervical cancer metastasis and associated with histone acetylation. However, the underlying molecular mechanisms of histone acetylation in cervical cancer EMT and metastasis are still elusive. METHODS: We systematically investigated the expression patterns of histone …

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Histone acetyltransferase CSRP2BP promotes the epithelial–mesenchymal transition and metastasis of cervical cancer cells by activating N-cadherin

Xiaohui Yang, Fei Sun, Yueying Gao, Mian Liu et autres

Abstract Background: Dysregulated epithelial–mesenchymal transition (EMT) is involved in cervical cancer metastasis and is associated with histone acetylation. However, the underlying molecular mechanisms of histone acetylation in cervical cancer EMT and metastasis are still elusive. Methods: Here, we systematically investigated the expression …

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Intracranial complete response to toripalimab and anlotinib in a patient with recurrent brain metastases of small cell lung cancer after failure of second-line maintenance therapy: a case report

Fengxiang Huang, Jiaqi Tang, Jiaojiao Lou, Qilong Wang et autres

Background: Approximately 10-25% of patients with small cell lung cancer (SCLC) have brain metastases at the time of diagnosis. Radiotherapy is a common treatment for brain metastases, but the relapse rates are high. Accumulating evidence suggests that immunotherapy may have a better …

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Back-to-back Schottky junction photodetectors based on CVD grown CsPbBr3 microcrystalline striped films

Di Cui, Cancan Tian, Yunpeng Wang, Fei Wang et autres

In recent years, a new type of lead halide perovskite has attracted a lot of attention for next-generation photodetectors (PDs) with high responsivity, good detectivity, and fast photoresponse speed. Specifically, cesium based all-organic perovskites exhibit better photostability and therefore have achieved increasing …

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Chemical Vapor Deposition Method Grown All-Inorganic Perovskite Microcrystals for Self-Powered Photodetectors

Cancan Tian, Fei Wang, Yunpeng Wang, Zhe Wei Yang et autres

Self-powered photodetectors (SPPDs) have attracted lots of attention due to their various advantages including no external power sources, high-sensitivity, fast response speed, and so on. This study reports the fabrication and characterization results of CsPbBr 3 microcrystals (MCs) grown by chemical vapor …

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Surface plasmon-enhanced two-photon excited whispering-gallery modes ultraviolet laser from Zno microwire

Yunpeng Wang, Gangbei Zhu, Jingjing Mei, Cancan Tian et autres

The two-photon excited UV laser with narrow line width and high Q value was obtained. The total internal reflection from the four side surfaces of the quadrilateral-ZnO microwire offered the whispering gallery mode (WGM) resonant cavity. The UV emission, resonant mechanism, and …

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