Qiaozhen Qin

Polyphenol-engineered selenium nanocatalysts enable neuroprotective glioblastoma chemoimmunotherapy via nose-to-brain delivery

Shunming Hong, Rong Hu, Qingbin Nie, Huaqiang Ruan et autres

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PBM alleviates depression and anxiety like behaviors in mice: insight from local field potential

Yifei Tan, Jinwei Liu, Huaqiang Ruan, Qiaozhen Qin et autres

BACKGROUND: Depression involves abnormal neural oscillations. Photobiomodulation (PBM) modulates such oscillations but lacks behavioral electrophysiological mechanistic studies. We explored PBM's effects on hippocampal CA1 oscillations and phase-amplitude coupling (PAC) in a depression model. METHODS: Male C57BL/6J mice were randomly divided into saline, …

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Transcranial photobiomodulation promotes traumatic brain injury recovery via modulating glial cell polarization and neuroinflammation: a study of 1064 nm light-emitting diodes

Guilin Chen, Zhenhua Xu, Hengchao Ma, Qiaozhen Qin et autres

BACKGROUND: Photobiomodulation (PBM) utilizing 1064 nm near-infrared light, renowned for its deep tissue penetration capabilities, has demonstrated significant therapeutic potential in addressing brain disorders; however, its specific effects and underlying mechanisms in traumatic brain injury (TBI) remain poorly understood. METHODS: , 12 …

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Undercarboxylated OCN Inhibits Chondrocyte Hypertrophy and Osteoarthritis Development through GPRC6A/HIF-1α Cascade

Zhangzhen Du, Yongqi Zhao, Ke Zhang, Qiaozhen Qin et autres

) mice and found that OCN absence increased collagen type X (COL10) and matrix metalloproteinase 13 (MMP13) expression in chondrocytes, despite a lack of severe OA phenotype. A declining trend of ucOCN in synovial fluid was observed in arthritis models and OA …

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Modulating oral microbiota ameliorates hypobaric hypoxia-induced anxiety- and depression-like behaviors in mice

Wen-Yue Chang, Qiaozhen Qin, Xiaotong Li, Jia-jing Wang et autres

BACKGROUND Hypobaric hypoxia exposure (HHE) often causes neuropsychiatric disorders. Due to its complex mechanism, efficient strategies for alleviating HHE-induced anxiety- and depression-like behaviors remain limited. AIM To characterize alterations in the oral and gut microbiota following HHE and to explore a potential …

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MiR-129-5p alleviates depression and anxiety by increasing astrocyte ATP production partly through targeting deubiquitinase Mysm1

Qiaozhen Qin, Heyang Zhang, Xiaotong Li, Huaqiang Ruan et autres

Major depressive disorder (MDD) is a major global mental concern that severely affects quality of life, yet current pharmacological treatments remain limited in their effectiveness. Long-term chronic stress has been shown to increase the incidence of depression and anxiety. Micro RNAs (miRNAs) …

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Ultrashort wave therapy promotes traumatic brain injury recovery by suppressing neuroinflammation

Chuang Xu, Jinwei Liu, Qiaozhen Qin, Heyang Zhang et autres

Despite growing treatments for traumatic brain injury, there is still no ideal strategy for efficiently mitigating these processes. Ultrashort wave therapy, a type of physical factor therapy, has been widely used in various clinical treatments. However, its effects on traumatic brain injury …

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Human Pituitary Organoids: Transcriptional Landscape Deciphered by scRNA‐Seq and Stereo‐Seq, with Insights into SOX3's Role in Pituitary Development

Shengjie Wang, Deyue Jiang, Yan Xiao, Qiaozhen Qin et autres

The 3D human pituitary organoid represents a promising laboratory model for investigating human pituitary diseases. Nonetheless, this technology is still in its nascent stage, with uncertainties regarding the cellular composition, intercellular interactions, and spatial distribution of the human pituitary organoids. To address …

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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors

Jiajun Zhou, Wenhao An, Lei Guan, Jinyu Shi et autres

Background: Primary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in tumor initiation and progression. However, the specific characteristics of the immune microenvironment and their clinical significance remain poorly understood. …

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ipRGCs Sensitive Blue Light Exposure Promotes the Robustness of Circadian and Neural Stem Cells in Sleep Deprived Conditions

Zhaoting Bu, Jinyu Shi, Qiaozhen Qin, Heyang Zhang et autres

Circadian rhythm abnormalities due to sleep deprivation (SD) may promote the development of emotional and cognitive disorders. Though light therapies have been employed to treat circadian disorders, the exact treatments and their underlying biology are still unclear. Our study aimed to investigate …

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Deubiquitinase MYSM1: An Important Tissue Development and Function Regulator

Qiaozhen Qin, Huaqiang Ruan, Heyang Zhang, Zhenhua Xu et autres

MYSM1, a deubiquitinating enzyme, plays a pivotal role in diverse biological processes. Both MYSM1 knockout mice and patients with Mysm1 gene mutations exhibit developmental abnormalities across multiple tissues and organs. Serving as a crucial regulator, MYSM1 influences stem cell function, immune responses, …

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Re-analysis of gene mutations found in pituitary stalk interruption syndrome and a new hypothesis on the etiology

Shengjie Wang, Qiaozhen Qin, Deyue Jiang, Yan Xiao et autres

Background: Pituitary stalk interruption syndrome (PSIS) is a complex clinical syndrome characterized by varied pituitary hormone deficiencies, leading to severe manifestations across multiple systems. These include lifelong infertility, short stature, mental retardation, and potentially life-threatening pituitary crises if not promptly diagnosed and …

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