Wenhao An

Chinese guidelines for the diagnosis and treatment of Craniopharyngioma in children (2025)

Zhixiong Lin, Jie Ma, Yonggao Mou, Songtao Qi et autres

This guideline was developed under the auspices of the Pediatric Neurosurgery Group of the Neurosurgery Branch of the Chinese Medical Association, the Neuro-oncology Expert Committee of the Chinese Society of Clinical Oncology, and the Neuro-oncology Professional Committee of the China Anti-Cancer Association. …

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Plasma GFAP and language‐network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis

Wei Han, Na Li, Peishen Wang, Wenhao An et autres

Abstract INTRODUCTION Amyloid burden may relate to semantic fluency through tau and astrocytic pathways, but their contributions remain unclear. METHODS In this cross‐sectional study, we analyzed 210 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with amyloid positron emission tomography (PET), tau PET, plasma …

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Pharmacological Treatment for Adamantinomatous Craniopharyngioma

Chuan Zhao, Bo Zhang, Wenhao An, Yi Lin et autres

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Stereotactic Radiosurgery for Craniopharyngioma Management: A Comprehensive Review of Treatment Outcomes, Dose Optimization, and Future Directions

Yi Lin, Ning Luo, Wenhao An, Z. Lin

Craniopharyngioma (CP), although histologically benign, is a surgically challenging sellar-region tumor for which stereotactic irradiation is increasingly used as an alternative or adjuvant strategy. This review summarizes the role of stereotactic radiosurgery (SRS) in managing CP, with a focus on treatment outcomes, …

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Targeted Therapy for Recurrent and Refractory Papillary Craniopharyngioma: A Systematic Narrative Review

Yi Lin, Ning Luo, Wenhao An, Zhixiong Lin

OBJECTIVE: To evaluate the efficacy and safety of targeted molecular therapy for recurrent and refractory papillary craniopharyngioma (PCP) and explore its potential as a neoadjuvant treatment. METHODS: This systematic and narrative review was performed following PRISMA guidelines to evaluate BRAF and MEK …

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The clinical significance of T cell infiltration and immune checkpoint expression in central nervous system germ cell tumors

Jiajun Zhou, Wenhao An, Lei Guan, Jinyu Shi et autres

Background: Primary central nervous system germ cell tumors (CNS GCTs) are rare intracranial malignancies, and their tumor microenvironment plays a crucial role in tumor initiation and progression. However, the specific characteristics of the immune microenvironment and their clinical significance remain poorly understood. …

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Molecular subtypes of adamantinomatous craniopharyngiomas

Wenhao An, Shouwei Li, Yihua An, Zhixiong Lin

Adamantinomatous craniopharyngioma (ACP) is the most common benign tumor in the sellar region of children and originates from embryonic remnants. Owing to its unique location and frequent tight adhesion to and invasion of surrounding structures, the ACP poses significant challenges for neurosurgical …

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High expression of SIGLEC7 may promote M2-type macrophage polarization leading to adverse prognosis in glioma patients

Wenhao An, Changyuan Ren, Lei Yuan, Zhiqiang Qiu et autres

Introduction: Gliomas are the most common primary intracranial tumors, known for their high invasiveness and destructiveness. Sialic acid-binding immunoglobulin-like lectin 7 (SIGLEC7) is present in various immune cells, especially macrophages, and significantly affects immune homeostasis and cancer cell response. However, research on …

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Identification of crosstalk genes and immune characteristics between Alzheimer’s disease and atherosclerosis

Wenhao An, Jiajun Zhou, Zhiqiang Qiu, Peishen Wang et autres

Background: Advancements in modern medicine have extended human lifespan, but they have also led to an increase in age-related diseases such as Alzheimer's disease (AD) and atherosclerosis (AS). Growing research evidence indicates a close connection between these two conditions. Methods: We downloaded …

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