Transcranial photobiomodulation promotes traumatic brain injury recovery via modulating glial cell polarization and neuroinflammation: a study of 1064 nm light-emitting diodes
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BACKGROUND: Photobiomodulation (PBM) utilizing 1064 nm near-infrared light, renowned for its deep tissue penetration capabilities, has demonstrated significant therapeutic potential in addressing brain disorders; however, its specific effects and underlying mechanisms in traumatic brain injury (TBI) remain poorly understood. METHODS: , 12 min/day) for 14 consecutive days post-TBI induction. Comprehensive behavioral assessments were conducted to evaluate emotional and cognitive functions. Advanced molecular analyses encompassing transcriptome sequencing, immunofluorescence, quantitative RT-PCR, and Western blot were employed to examine brain tissue damage, neurogenesis, synaptic remodeling, and inflammatory responses. RESULTS: The 1064 nm LED treatment demonstrated remarkable therapeutic effects, significantly ameliorating anxiety, depression-like behaviors, and spatial cognitive deficits in TBI mice. Behavioral improvements were evidenced by enhanced rotarod performance, increased exploratory behavior in open field and elevated plus maze tests, and improved Y-maze alternation rates. At the molecular level, PBM intervention exhibited multifaceted neuroprotective effects, including inhibition of neuronal apoptosis, reduction of brain injury, promotion of neurogenesis and synaptic remodeling, and upregulation of neurotrophic factors. Furthermore, the treatment enhanced blood-brain barrier integrity through upregulation of tight junction proteins and modulated neuroinflammation by shifting microglia and astrocytes toward anti-inflammatory phenotypes. CONCLUSIONS: These findings collectively demonstrate that 1064 nm wavelength PBM treatment effectively promotes functional recovery and mitigates both emotional and cognitive impairments in TBI mice, providing novel mechanistic insights and a promising wavelength option for PBM-based therapeutic strategies in TBI management.
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DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Transcranial photobiomodulation promotes traumatic brain injury recovery via modulating glial cell polarization and neuroinflammation: a study of 1064 nm light-emitting diodes
- Date Crossref
- 07/11/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese PLA General Hospital pays non établi dans la noticeÉtablissement de santé
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Beijing Institute of Education pays non établi dans la noticeStructure de recherche
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Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences pays non établi dans la noticeStructure de recherche
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Anhui Medical University pays non établi dans la noticeUniversité ou école supérieure
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Jishou University pays non établi dans la noticeUniversité ou école supérieure
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The First Medical Center Department of Neurosurgery pays non établi dans la noticeÉtablissement de santé
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Graduate School of the PLA General Hospital pays non établi dans la noticeUniversité ou école supérieure
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Beijing Institute of Basic Medical Sciences pays non établi dans la noticeStructure de recherche
Chinese PLA General Hospital, Beijing Institute of Education et Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.