Guillermo Suárez-Cuartín

Dupilumab-induced eosinophilia in severe asthma: 2-year follow-up real-life evidence from biologic-naïve and previously treated patients

C. Bellver-Asperilla, Ana Romero Ortíz, Héctor Cabrerizo-Carreño, Sandra Orozco Echeverría et autres

Data from real-life settings regarding dupilumab-associated eosinophilia remains limited, particularly concerning potential risk factors for developing hypereosinophilia after treatment initiation. METHODS: We conducted a prospective observational study including an initial cohort of 36 patients with severe asthma treated with dupilumab and followed …

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A prospective cohort study for characterization and predictive factors of long-term POST-COVID interstitial changes

M. Hernandez-Argudo, J. Bordas-Martinez, V Vicens-Zygmunt, Guadalupe Bermudo et autres

INTRODUCTION: Chronic interstitial lung changes are potential long-term sequelae of severe COVID-19. This study aims to evaluate the prevalence and type of interstitial changes over time and identify serum biomarkers associated with persistent lung abnormalities. METHODS: Prospective, multicenter, observational cohort study of …

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Dupilumab-induced eosinophilia in severe asthma: 2-year follow-up real-life evidence from biologic-naïve and previously treated patients

Cristina Bellver-Asperilla, M. Alexandra Muñoz, Ana Romero Ortíz, Héctor Cabrerizo-Carreño et autres

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Frequent exacerbators and neutrophil elastase activity in bronchiectasis: a network analysis approach

Pau Marrades, Julieta Viglino, Lídia Perea, Belén Solarat et autres

Extract Bronchiectasis (BE) is a heterogeneous chronic lung disease characterized by abnormal and permanent dilatation of the bronchi, persistent inflammation, impaired mucociliary clearance and recurrent respiratory infections [1, 2].

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Combining Airway Clearance Techniques and Inhaled Antibiotics in Chronic Bronchial Infection: Real-World Evidence of Exacerbation Reduction (INBREATHING Study)

Aída Monge, Ane Martínez-De las Fuentes, Javier Burgos, Cristina Pou et autres

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T6 Genetic characterisation of pseudomonas aeruginosa isolates from bronchiectasis patients in a randomized, double-blind placebo-controlled trial of a bispecific monoclonal antibody targeting Psl and PcrV (GREAT-2)

RC Hull, M.B. Long, Amy Gilmour, I.D. Petrou et autres

Introduction Pseudomonas aeruginosa (PA) airway infections in bronchiectasis are associated with increased disease severity and exacerbations. New treatment options are needed due to inconsistent results with inhaled antibiotics and increasing concerns over antimicrobial resistance. The GREAT-2 trial of gremubamab, a bispecific monoclonal …

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Systemic Immune Dysregulation in Patients With Bronchiectasis and Chronic Pseudomonas aeruginosa Infection

Belén Solarat, Núria Mendoza, Lídia Perea, Rosanel Amaro et autres

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Telomere Length and Survival in Patients with Locally Advanced UnresectableNon-small Cell Lung Cancer (NSCLC): Is There a Relationship?

Alfredo Marín Muñiz, Olivia Jordi-Ollero, Beatriz Fernández-Varas, Mónica Arellano-Vengoechea et autres

Introduction: Telomerase is overexpressed in 80% of tumors, preventing telomere shortening and providing cellular immortality. Immunotherapy (IT) after concurrent chemoradiotherapy (CCRT) has a benefit in overall survival (OS) in patients with NSCLC PDL-1 positive. Objective: to analyze the relationship between telomere length …

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Relationship Between Telomere Length and Pulmonary Toxicity in Patients with Locally Advanced Unresectable Non-small cell lung cancer (NSCLC)

Alfredo Marín Muñiz, Olivia Jordi-Ollero, Beatriz Fernández-Varas, Mónica Arellano-Vengoechea et autres

Introduction: Telomere length (TL) is involved in tissue repair. Pulmonary toxicity (PT) due to radiotherapy (RT) is a complication of NSCLC treatment, being a risk factor under study. Objective: Analyze the relationship between TL and PT due to RT in patients with …

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Follow-up of patients with severe asthma using a conversational AI virtual assistant: feasibility and impact

Mariana Mercedes Muñoz Esquerre, Héctor Cabrerizo Carreño, Anna Rosich Fírvida, Ana Romero Ortíz et autres

Introduction: The follow-up of patients with severe asthma (SA) represents a current challenge due to disease control variability requiring long-term monitoring. This study aimed to evaluate the feasibility and impact, in terms of reach and adherence, of a follow-up program using a …

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A bispecific monoclonal antibody targeting Pseudomonas aeruginosa in bronchiectasis: results from the GREAT-2 trial

Merete Bridget Long, Rebecca C Hull, Amy Gilmour, Kateryna Viligorska et autres

Rationale: We report a randomized, double-blind, placebo-controlled trial of gremubamab, a bispecific mAb targeting Psl exopolysaccharide and PcrV T3SS component, in people with bronchiectasis and P. aeruginosa infection. Methods: Patients were randomised 1:1:1 to 1500mg or 500mg gremubamab IV infusion, or placebo, …

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Viability of a new home program of forced spirometry with bronchodilator response measurement in the assessment of patients with asthma

Héctor Cabrerizo Carreño, Cristina Bellver Asperilla, Ana Maria Romero-Ortiz, Salud Santos et autres

BACKGROUND: Home spirometry using portable devices offers a potential alternative for asthma management by reducing hospital dependence and improving accessibility. This study aimed to assess the feasibility of a home spirometry program with bronchodilator response (BDR) testing performed without direct medical supervision. …

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