Accès ouvert
2026
article
OpenAlex
Michal Shteinberg, Charles Haworth, Jennifer Pollock, Shai Cohen et autres
Introduction: Chronic rhinosinusitis (CRS) is a common comorbidity in bronchiectasis. Previous studies suggested that bronchiectasis with CRS is associated with elevated type 2 biomarkers, representing an "eosinophilic bronchiectasis" phenotype. However, whether the association with type 2 inflammation exists in rare aetiologies of …
il, gb, gr, it, de, es, fr, se, fi, rs, pl, md, pt, be
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Accès ouvert
2026
article
OpenAlex
Rebecca C Hull, Yang Liu, Zu Cao, Kathryna Tan Li Xuan et autres
BACKGROUND: Bronchiectasis and diabetes commonly coexist and are associated with immune dysfunction and increased susceptibility to infection. Although diabetes is associated with worse prognosis in cystic fibrosis-related bronchiectasis, data are scarce for its impact on non-cystic fibrosis bronchiectasis. This study aimed to …
gb, cn, kr, sg, fr, es, in, be, il, de, gr, ie, it, au
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Accès ouvert
2026
article
OpenAlex
Ana Catalina Hernandez Padilla, Kateryna Viligorska, Juan Pablo Rodriguez Ruiz, Letizia Traversi et autres
Acute respiratory tract infections represent a significant burden in primary care, with antibiotics often prescribed unnecessarily. This contributes to the escalating threat of antimicrobial resistance (AMR) by increasing the burden of infectious diseases and mortality risk. This is a report from a …
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Accès ouvert
2026
preprint
OpenAlex
M Bottier, Erin Cant, Lidia Gómez Perea, Morven K Shuttleworth et autres
Abstract Mucociliary clearance is a key component of the pathophysiology of bronchiectasis but cilia function is poorly defined. This study aims to characterize nasal ciliary function in bronchiectasis and examine associations with disease severity, infection, inflammation and outcome. Adults with bronchiectasis and …
gb, us, es, Égypte, it, be, nl, il
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Accès ouvert
2025
article
OpenAlex
Kateryna Viligorska
INNOVATE was a prospective observational cohort study of hospitalized patients admitted to Ninewells Hospital, Dundee, United Kingdom. INNOVATE recruited hospitalized patients between December 2022 and March 2023. Patients were recruited upon admission with PCR virus positive test for influenza, SARS-CoV-2 or other …
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2025
conference-paper
OpenAlex
RC Hull, M.B. Long, Amy Gilmour, I.D. Petrou et autres
Introduction Pseudomonas aeruginosa (PA) airway infections in bronchiectasis are associated with increased disease severity and exacerbations. New treatment options are needed due to inconsistent results with inhaled antibiotics and increasing concerns over antimicrobial resistance. The GREAT-2 trial of gremubamab, a bispecific monoclonal …
gb, it, es, fi, nl
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2025
conference-abstract
OpenAlex
Kateryna Viligorska, Jeffrey T.-J. Huang, Holly Lind, Kara Robertson et autres
Introduction: Studies exploring the neutrophil proteome in COVID-19 showed a key role for neutrophils in viral infection, with changes during acute infection linked to disease severity and outcomes. Data on neutrophil proteome is lacking in other viral infections. Understanding neutrophil proteomic and …
gb
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2025
conference-abstract
OpenAlex
Erin Cant, Morven K. Shuttleworth, Emma Johnson, Thomas Pembridge et autres
Introduction: In BE dysfunction of the respiratory epithelium contributes to disease pathogenesis and may represent a target for therapy. Few studies have characterized the lower airway epithelium in BE. Methods: This prospective observational study conducted in-depth characterisation of the epithelium in BE …
gb, sg, ch, es, fi
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2025
conference-abstract
OpenAlex
Chloe Hughes, B Long Merete, Kateryna Viligorska, Jamie Stobo et autres
Introduction: Bronchiectasis is a systemic inflammatory disease with a proposed role for neutrophils in disease pathogenesis. The mechanisms leading to systemic inflammation are not well understood. Methods: Multi-centre, international observational study of patients with stable bronchiectasis (BRIDGE study; NCT03791086 ). Patients were …
gb, be, il, it, nl, es, de, gr, pt, ie
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2025
conference-abstract
OpenAlex
Amelia Shoemark, Holly Lind, Kateryna Viligorska, Pieter Goeminne et autres
PCD is an inherited cause of bronchiectasis. EMBARC-BRIDGE is a translational research substudy embedded within the European Bronchiectasis Registry. We compare patients with PCD in EMBARC BRIDGE to bronchiectasis of other causes. Adults with bronchiectasis were recruited to an observational cohort study …
gb, be, il, it, nl, es, de, gr, pt, ie
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Michal Shteinberg, Charles Haworth, Jennifer Polliock, Shai Cohen et autres
Introduction: Chronic rhinosinusitis (CRS) and nasal polyposis (NP) are common comorbidities in bronchiectasis. We aimed to assess the prevalence, impact, and association of CRS and NP with type 2 inflammatory biomarkers in people with bronchiectasis. Methods: Using the EMBARC bronchiectasis registry, we …
il, gb, gr, it, de, es, fr, se, fi, rs, md, ir, ge, pt, be, nl
(code pays fourni par la source)
2025
conference-abstract
OpenAlex
Merete Bridget Long, Rebecca C Hull, Amy Gilmour, Kateryna Viligorska et autres
Rationale: We report a randomized, double-blind, placebo-controlled trial of gremubamab, a bispecific mAb targeting Psl exopolysaccharide and PcrV T3SS component, in people with bronchiectasis and P. aeruginosa infection. Methods: Patients were randomised 1:1:1 to 1500mg or 500mg gremubamab IV infusion, or placebo, …
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