Paulo Costa

Sub-Saharan African Prostate Cancer Patient-Derived Cell Lines and High-Throughput Drug Screening: Addressing Ancestry Underrepresentation in Oncobiology Research

Carla S. dos Santos, Ana C. Magalhães, Verônica Elizeu de Araújo Fernandes, Antonio R. Pombinho et autres

Background/Objectives: Prostate cancer (PC) exhibits marked disparities in incidence and mortality across ethnicities, with men of Sub-Saharan African (SSA) ancestry experiencing 1.7 and 2.0 times higher values, respectively, than European men (EUR). However, SSA preclinical models remain scarce (just one commercial cell …

pt (code pays fourni par la source)

Bridging prediction and reality: AI-based external validation of predictive models for lymph node metastasis in gastric cancer

Lúcio Lara Santos, Anna Carolina Finamore, Suzanne Sarah Gisbertz, Uberto Fumagalli Romario et autres

INTRODUCTION: The optimal extent of lymphadenectomy in gastric cancer surgery remains a subject of ongoing debate. Our previous modelling work indicated that identifying at least 26 lymph nodes may reveal occult nodal metastases in patients undergoing more limited dissections, thereby reducing the …

pt, nl, it, pl, ch, de, gb, es, fr, ie (code pays fourni par la source)

Hydrological disasters and health losses: an index-based analysis for Brazil

José Firmino de Sousa Filho, Thomás Rocha Ferreira, Paulo Costa, Andreia Ferreira et autres

OBJECTIVE: To develop and apply composite indices to assess immediate losses caused by hydrological disasters in Brazil between 2000 and 2023, with a focus on human losses and damages to health infrastructure. METHODS: Data were obtained from the Integrated Disaster Information System, …

br, gb (code pays fourni par la source)

Characterization of Th2 Serum Immune Response in Acute Appendicitis

Nuno Vaz Carvalho, Jani Sofia Almeida, Elisabete Carolino, Francisco Lopes et autres

Acute Appendicitis (AA) is the commonest abdominal digestive surgical emergency, but its etiology is not clarified. Based on histologic observations, an allergic cause has been proposed. In a type I hypersensitivity allergic reaction, there is a Th2 immune response characterized by Th2 …

pt (code pays fourni par la source)

OS EFEITOS DE LONGO PRAZO DA QUIMIOTERAPIA E RADIOTERAPIA EM SOBREVIVENTES DE LEUCEMIA INFANTIL

Jonas de Souza, DAOANA SALES DA CRUZ NEGREIROS, Paulo Costa

Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study

Claudia Neves-Marques, Mohamed Abulazayem, Geoffrey Yuet Mun Wong, Ricardo David Maldonado et autres

BACKGROUND: Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, …

pt, Égypte, gb, au, ie, us, ru, Soudan, tr, jo, ye, sy, pk, ar, Tunisie, hr, it, gr, mn, fr, si, co, jp, pl, il, Algérie, az, in, bg, Maroc (code pays fourni par la source)

Large-scale trauma education for all? Learner perspective and implementation insights

Margarida Silva Ferreira, Muriel Lérias-Cambeiro, Paulo Almeida, Carlos Luz et autres

Trauma represents a significant global health burden, yet dedicated trauma education is frequently deficient in undergraduate medical curricula. Consequently, medical students often report lack of preparedness to manage trauma cases. The optimal approach to integrate trauma education in medical school curricula remains …

pt (code pays fourni par la source)

Correction: Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT

Adam P. Wagner, Virve I. Enne, Vanya A. Gant, Susan Stirling et autres

Following publication of the original article [1], the authors identified an error in the author name of Virve I. Enne. The incorrect author name is: Virvel Enne. The correct author name is: Virve I. Enne. The author group has been updated above …

gb (code pays fourni par la source)

ASO Visual Abstract: Staging Laparoscopy in Patients with Gastric Cancer Treated with Curative Intent—A European GASTRODATA Cohort Study

Katarzyna Sędłąk, Sebastian Kobiałka, Zuzanna Pelc, Yutaka Endo et autres

pl, us, de, nl, it, es, ch, fr, pt, gb (code pays fourni par la source)

Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Kaja Abbas et autres

BACKGROUND: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital …

PRÁTICAS AGROECOLÓGICAS E ECONOMIA CIRCULAR NO FORTALECIMENTO DAS COMUNIDADES QUILOMBOLAS NA AMAZÔNIA

Hinton Bentes, Paulo Costa, João Paulo Bastardo Rodrigues

This study aims to analyze the impact of the PROMED project – Promotion of Medicinal Plants in the Amazon Ecosystems – in the quilombola communities of Breu Branco, focusing on the integration of traditional knowledge and sustainable technologies. The methodology used includes …

pe, br (code pays fourni par la source)

Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT

Adam P. Wagner, Virve I. Enne, Vanya A. Gant, Susan Stirling et autres

BACKGROUND: Hospital-acquired and ventilator-associated pneumonia (HAP and VAP) are pneumonias arising > 48 h after admission or intubation respectively. Conventionally, HAP/VAP patients are given broad-spectrum empiric antibiotics at clinical diagnosis, refined after 48-72 h, once microbiology results become available. Molecular tests offer …

gb (code pays fourni par la source)