Aller au contenu principal
Accès ouvert déclaré2025article

Stomach cancer elective surgery morbidity and mortality at 90-Day (Hold Study): a prospective, international collaborative cohort study

0Citations signalées
81Institutions associées
32Pays d’affiliation

Résumé fourni par la source

BACKGROUND: Data on multinational 90-day mortality and morbidity rates after surgery for gastric cancer is limited in the literature. This study aimed to understand the 90-day mortality and morbidity outcomes among patients undergoing elective gastric cancer surgery, as in the GASTRODATA Registry, and to identify associated risk factors. METHODS: We conducted an international prospective study on patients aged ≥ 18 years undergoing elective surgery for gastric cancer with curative intent from January 4 to September 30, 2022. Known metastatic disease, concurrent secondary cancers, gastrointestinal stromal tumour (GIST) and Siewert type I/II oesophagogastric junction malignancies were excluded. Univariate and multivariate logistic regression were used to identify variables associated with the 90-day outcome. RESULTS: 380 collaborators from 47 countries submitted data on 1538 patients. Median age was 65 years (IQR: 19-94), and 58.5% were males. 90-day morbidity and mortality rates were 38.2% (n = 587) and 2.9% (n = 45), respectively. Pre-operative higher Charlson Comorbidity Index, higher ASA score, pre-operative weight loss > 10%, positive specimen margin, and post-operative pathological IV staging (p value < 0.05) were significantly associated with clinically relevant complications and mortality. CONCLUSION: Elective gastric cancer surgery has a 90-day morbidity of 38.2% and a 90-day mortality of 2.9% globally. This study provided the most comprehensive international 90-day prospective data to date regarding gastric cancer surgery. Several factors associated with higher morbidity were identified, highlighting the importance of a unified language on surgical morbidity, prehabilitation, and ongoing audits to enhance patient outcomes.

Institutions

Universidade Nova de LisboaCairo UniversityNational Heart InstituteImperial College LondonRoyal Adelaide HospitalJames Cook University HospitalUniversity Hospitals of Leicester NHS TrustSt. James's HospitalAdvocate Illinois Masonic Medical CenterUniversity of Illinois ChicagoUniversity Hospitals Coventry and Warwickshire NHS TrustP.A. Hertzen Moscow Oncology Research InstituteNational Ribat UniversityDicle UniversityJordan Hospital21 September University for Medical and Applied SciencesUniversity of CoimbraDamascus HospitalCivil Hospital KarachiHospital PrivadoShaukat Khanum Memorial Cancer Hospital and Research CenterAin Shams UniversityGuy's and St Thomas' NHS Foundation TrustHopital Universitaire Habib BourguibaHospital de São JoãoLatakia UniversityKlinički bolnički centar OsijekBakırköy Dr.Sadi Konuk Eğitim ve Araştırma HastanesiUniversity of BolognaOspedale L. BonomoMarmara UniversityAthens Medical CenterSamsun UniversityHospital de Santo AntónioCentro Hospitalar do PortoSt Petersburg UniversityOspedale G.B. Morgagni - L.PierantoniSiberian State Medical UniversityMongolian National University of Medical SciencesIstanbul University-CerrahpaşaImmanuel Kant Baltic Federal UniversityHospital Prof. Dr. Fernando FonsecaSorbonne UniversitéAssistance Publique – Hôpitaux de ParisPitié-Salpêtrière HospitalFirst Pavlov State Medical University of St. PetersburgLjubljana University Medical CentreInstituto Nacional de CancerologíaKonya Food and Agriculture UniversityKonya Eğitim ve Araştırma HastanesiInstituto de GastroenterologíaNational Cancer Center Hospital EastUniversity of GlasgowMedical University of SilesiaHebrew University of JerusalemHadassah Medical CenterUnidade Local de Saúde de Trás-os-Montes e Alto DouroUniversity Hospital of OranBağcılar Eğitim ve Araştırma HastanesiGeneral University Hospital of PatrasOspedale Civile Edoardo AgnelliAzerbaijan Medical UniversityUniversity of Naples Federico IIChristian Medical College, VelloreChristian Medical CollegeDelhi State Cancer InstituteUniversity of FoggiaPontificia Universidad JaverianaTrakia UniversityNational and Kapodistrian University of AthensMohammed V UniversityHacettepe UniversityHippocration General HospitalUniversity of UdineUniversity of CataniaPoliclinico Universitario di CataniaPenang Adventist HospitalWojskowy Instytut Medycyny LotniczejUniversity Hospitals Birmingham NHS Foundation TrustSouth Tyneside and Sunderland NHS Foundation TrustUniversity of Sunderland

Sujets associés

Gastric Cancer Management and OutcomesEnhanced Recovery After SurgeryHelicobacter pylori-related gastroenterology studies

BNTIC News n’est pas le producteur de ces données. Métadonnées interrogées à la demande auprès de OpenAlex (CC0). Sources et limites.