Characterization of Th2 Serum Immune Response in Acute Appendicitis
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Le résumé fourni par la source
Acute Appendicitis (AA) is the commonest abdominal digestive surgical emergency, but its etiology is not clarified. Based on histologic observations, an allergic cause has been proposed. In a type I hypersensitivity allergic reaction, there is a Th2 immune response characterized by Th2 cells, eosinophils, basophils, IgE, IL-4, IL-5, and IL-13 serum elevation. Recent studies showed a local appendicular endoluminal and parietal Th2 immune response in acute phlegmonous appendicitis. We performed a prospective single-center study where we evaluated the Th2 blood immune response in 38 patients with acute phlegmonous appendicitis, 27 patients with acute gangrenous appendicitis, and 18 patients with the clinical picture of AA, who underwent appendectomy but had negative histology for AA (negative appendectomy group). Higher levels of basophils were found in phlegmonous appendicitis (p = 0.03), and higher levels of eosinophils were found in the control group (p = 0.003). Effector memory CD4 T cells re-expressing CD45RA were higher in gangrenous (p = 0.020) and central memory CD4 T cells in phlegmonous appendicitis (p = 0.004). The number of Th2 circulating cells was higher in gangrenous appendicitis (p = 0.037), while Th1 circulating cells were higher in phlegmonous appendicitis (p = 0.028). IL-4 blood concentrations were elevated in acute gangrenous appendicitis (p = 0.029). No significant differences were found in the levels of IgE, IL-5, or IL-13 in any of the groups. Thus, a Th2 response was not detected in patients’ serum with phlegmonous appendicitis. Serum levels of IgE, IL-5, and IL-13 were not different among patients with acute phlegmonous appendicitis, acute gangrenous appendicitis, and the negative appendectomy group. These findings are in contrast to our previous work in which we evaluated the Th2 response at the local level, at the appendicular luminal aspect and appendicular wall, in phlegmonous appendicitis and control groups, and we unequivocally showed a Th2 response in phlegmonous appendicitis. Thus, in patients with phlegmonous appendicitis, the local Th2 response is not reflected in the serum levels of immune cells and cytokines.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characterization of Th2 Serum Immune Response in Acute Appendicitis
- Date Crossref
- 11/01/2026
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Lisbon pays non établi dans la noticeUniversité ou école supérieure
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Hospital Garcia de Orta Serviço Cirurgia Geral pays non établi dans la noticeÉtablissement de santé
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Instituto Português de Oncologia de Coimbra Francisco Gentil pays non établi dans la noticeStructure de recherche
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Centro de Investigação em Meio Ambiente Genética e Oncobiologia pays non établi dans la noticeUniversité ou école supérieure
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University of Coimbra Center for Innovation in Biomedicine and Biotechnology [CIBB] pays non établi dans la noticeUniversité ou école supérieure
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Instituto Politécnico de Lisboa pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigação em Saúde e Tecnologia pays non établi dans la noticeStructure de recherche
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Instituto de Histologia e Biologia do Desenvolvimento pays non établi dans la noticeUniversité ou école supérieure
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Instituto Gulbenkian de Ciência pays non établi dans la noticeUniversité ou école supérieure
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Universidade Lisboa Faculdade Medicina pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Genetics and Oncobiology [CIMAGO] pays non établi dans la noticeUniversité ou école supérieure
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Clinical Academic Center of Coimbra [CACC] pays non établi dans la noticeÉtablissement de santé
University of Lisbon, Serviço Cirurgia Geral — Hospital Garcia de Orta et Instituto Português de Oncologia de Coimbra Francisco Gentil, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.